CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = R206S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 206 | R206S | R6658S | nonsyn | agG | agT | 7684 | 7670 | 0.998178 | 20236-20238 |
| ORF1ab/nsp15A1-B | 206 | R206S | R6658S | nonsyn | agG | agC | 7684 | 14 | 0.00182197 | 20236-20238 |
Details of the mutation R206S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 7670 | 7684 | All | 0.001467 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 14 | 7684 | All | 0.000003 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5115 | 5115 | B.1.177.21 | 0.391145 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 336 | 337 | B.1.1.7 | 0.000301 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 1 | 337 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 293 | 293 | AY.4 | 0.000456 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 276 | 277 | B.1.617.2 | 0.001039 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 1 | 277 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 200 | 200 | B.1.1.25 | 0.113701 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 199 | 199 | D.5 | 0.99005 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 114 | 114 | AY.44 | 0.000694 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 105 | 105 | AY.9.1 | 0.008791 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 74 | 74 | B.1.429 | 0.001741 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 64 | 64 | AY.103 | 0.000397 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 58 | 58 | AY.25 | 0.000349 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 56 | 57 | B.1 | 0.000513 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 1 | 57 | B.1 | 0.000009 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 36 | 40 | AY.43 | 0.000159 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 4 | 40 | AY.43 | 0.000018 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 37 | 37 | AY.6 | 0.001522 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 32 | 32 | B.1.177 | 0.000421 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 31 | 31 | B.1.1 | 0.000562 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 31 | 31 | B.1.1.317 | 0.012762 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 30 | 30 | B.1.1.311 | 0.010745 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 29 | 29 | AY.102 | 0.000769 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 28 | 28 | AY.29 | 0.000442 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 28 | 28 | AY.3 | 0.000278 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 26 | 26 | B.1.36 | 0.003793 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 21 | 21 | B.1.1.33 | 0.008838 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 20 | 20 | AY.5.3 | 0.006748 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 20 | 20 | B.1.160 | 0.000624 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 19 | 19 | AY.5 | 0.000392 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 19 | 19 | B.1.1.50 | 0.012899 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 17 | 17 | B.1.1.341 | 1 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 17 | 17 | B.1.131 | 0.149123 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 13 | 16 | B.1.2 | 0.000114 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 3 | 16 | B.1.2 | 0.000026 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 15 | 15 | D.4 | 1 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 11 | 11 | B.1.1.369 | 0.004909 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 10 | 10 | AY.20 | 0.000389 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 9 | 9 | AY.39 | 0.000222 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 8 | 8 | AY.5.4 | 0.002214 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 7 | 7 | AY.33 | 0.000467 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 7 | 7 | B.1.258 | 0.000466 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 7 | 7 | B.1.36.1 | 0.007982 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 6 | 6 | AY.75 | 0.000336 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 6 | 6 | AY.98 | 0.000474 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 6 | 6 | B.1.1.519 | 0.000238 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | AY.119 | 0.000177 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 5 | AY.4.2 | 0.000087 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 1 | 5 | AY.4.2 | 0.000022 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | AY.45 | 0.000608 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | AY.47 | 0.000156 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | B.1.1.222 | 0.00102 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | C.37 | 0.00058 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 5 | 5 | Q.3 | 0.000725 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | A.23.1 | 0.002817 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | AY.46.5 | 0.000794 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | AY.99.2 | 0.000369 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | B.1.243 | 0.000278 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | B.1.427 | 0.000202 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | B.1.621 | 0.000354 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 4 | 4 | P.2 | 0.000747 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | A.2.5 | 0.001497 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.120.1 | 0.000963 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.23 | 0.000209 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.30 | 0.001187 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.7.1 | 0.000338 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.74 | 0.000347 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.77 | 0.003382 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.85 | 0.001282 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.9.2 | 0.00011 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | AY.99 | 0.003148 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | B.1.1.521 | 0.016043 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | B.1.177.86 | 0.00055 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | C.36 | 0.002732 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 3 | 3 | P.1 | 0.000047 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | A.2.2 | 0.003378 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.100 | 0.000092 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.107 | 0.000932 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.108 | 0.002205 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.109 | 0.001479 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.111 | 0.000366 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.116.1 | 0.000623 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.3.1 | 0.000171 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.36 | 0.000296 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.4.2.1 | 0.000298 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.4.4 | 0.000818 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.4.5 | 0.000215 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.46 | 0.000208 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.5.1 | 0.007519 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.54 | 0.000191 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.1.1.409 | 0.005666 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.1.1.63 | 0.000772 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.1.177.32 | 0.002699 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.1.177.73 | 0.001133 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.1.190 | 0.02 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | B.4 | 0.004415 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 2 | 2 | B.40 | 0.000729 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 2 | 2 | D.2 | 0.00015 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | A.2.5.2 | 0.001572 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | A.3 | 0.002096 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AD.1 | 0.004115 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AE.8 | 0.000489 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AU.2 | 0.002421 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.101 | 0.00049 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.110 | 0.000113 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.120.2.1 | 0.000498 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.19 | 0.00114 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.28 | 0.00189 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.34.1 | 0.00051 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.38 | 0.000499 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.5.2 | 0.002463 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.57 | 0.000656 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.58 | 0.000907 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.63 | 0.000387 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.65 | 0.000533 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.68 | 0.000274 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.79 | 0.001211 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.86 | 0.00083 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | AY.99.1 | 0.001553 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.229 | 0.005747 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.269 | 0.001353 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.279 | 0.001121 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.294 | 0.001266 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.315 | 0.008475 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.1.380 | 0.009804 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.177.35 | 0.000691 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.177.72 | 0.00339 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.201 | 0.005682 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.298 | 0.002114 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.324 | 0.001605 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.36.8 | 0.001 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.439 | 0.005917 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.448 | 0.002625 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agC | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.544 | 0.006024 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.573 | 0.006098 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.599 | 0.00365 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.619.1 | 0.000641 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.627 | 0.00202 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.91 | 0.002075 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.1.93 | 0.000934 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | B.28 | 0.003279 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | P.1.16 | 0.000374 |
| ORF1ab/nsp15A1-B | 206 | R206S | agG | agT | 1 | 1 | R.1 | 0.00009 |
 |
 |
CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
|