CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = Q196H
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 196 | Q196H | Q6648H | nonsyn | caG | caT | 1180 | 1173 | 0.994068 | 20206-20208 |
| ORF1ab/nsp15A1-B | 196 | Q196H | Q6648H | nonsyn | caG | caC | 1180 | 7 | 0.0059322 | 20206-20208 |
Details of the mutation Q196H within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1173 | 1180 | All | 0.000224 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 7 | 1180 | All | 0.000001 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 336 | 336 | B.1.1.7 | 0.000301 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 105 | 105 | AY.33 | 0.007012 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 84 | 85 | AY.4 | 0.000131 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 1 | 85 | AY.4 | 0.000002 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 78 | 78 | B.1.1.461 | 0.939759 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 50 | 50 | B.1.2 | 0.00044 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 36 | 38 | B.1.617.2 | 0.000136 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 2 | 38 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 37 | 37 | AY.44 | 0.000225 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 37 | 37 | B.1.160 | 0.001154 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 32 | 32 | B.1.1.519 | 0.001271 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 30 | 30 | R.1 | 0.0027 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 26 | 26 | AY.103 | 0.000161 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 23 | 23 | AY.42 | 0.000925 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 23 | 23 | B.1.1.222 | 0.004692 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 21 | 21 | B.1.621 | 0.001859 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 15 | 15 | B.1 | 0.000137 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 14 | 14 | AY.95 | 0.010654 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 12 | 13 | B.1.1 | 0.000218 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 1 | 13 | B.1.1 | 0.000018 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 12 | 12 | AY.43 | 0.000053 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 12 | 12 | Q.8 | 0.001979 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 10 | 10 | A.23.1 | 0.007042 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 6 | 6 | AY.25 | 0.000036 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 6 | 6 | AY.26 | 0.00017 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 6 | 6 | B.1.480 | 0.014925 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 6 | 6 | P.1 | 0.000095 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 5 | 5 | AY.120 | 0.000186 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 5 | 5 | AY.39 | 0.000124 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 5 | 5 | AY.61 | 0.000524 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 4 | 4 | AY.100 | 0.000184 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 4 | 4 | AY.45 | 0.000487 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 4 | 4 | AY.72 | 0.005442 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 4 | 4 | B.1.1.389 | 0.024242 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 3 | AY.29 | 0.000032 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 1 | 3 | AY.29 | 0.000016 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | AY.3 | 0.00003 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | AY.5 | 0.000062 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | AY.6 | 0.000123 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | AY.99.2 | 0.000276 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.177.15 | 0.001893 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.192 | 0.027778 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.36 | 0.000438 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.36.10 | 0.014354 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.36.29 | 0.001552 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.369 | 0.000856 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | B.1.596 | 0.000261 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 3 | D.2 | 0.00015 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 1 | 3 | D.2 | 0.000075 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | P.1.17 | 0.000485 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 3 | 3 | P.2 | 0.00056 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | AY.110 | 0.000225 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | AY.47 | 0.000062 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | AY.99 | 0.002099 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.1.158 | 0.02439 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.1.214 | 0.000111 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.1.294 | 0.002532 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.258.9 | 0.01 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.396 | 0.001411 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.404 | 0.002604 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.427 | 0.000101 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | B.1.609 | 0.000959 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | C.16 | 0.002121 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | P.1.2 | 0.002312 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 2 | 2 | P.1.7 | 0.000639 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.28 | 0.00189 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.60 | 0.000938 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.94 | 0.000443 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.161 | 0.003534 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.176 | 0.000439 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.200 | 0.007463 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.326 | 0.001761 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.409 | 0.002833 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.51 | 0.001718 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.523 | 0.001563 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.1.58 | 0.005376 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.177.23 | 0.003236 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.177.69 | 0.001484 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.177.83 | 0.001481 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.22.1 | 0.03125 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.232 | 0.000537 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.36.8 | 0.001 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.521 | 0.004975 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caC | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.605 | 0.005952 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.627 | 0.00202 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.1.629 | 0.013333 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp15A1-B | 196 | Q196H | caG | caT | 1 | 1 | K.2 | 0.04 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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