CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = M271I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 271 | M271I | M6723I | nonsyn | atG | atT | 2648 | 1486 | 0.561178 | 20431-20433 |
| ORF1ab/nsp15A1-B | 271 | M271I | M6723I | nonsyn | atG | atA | 2648 | 1140 | 0.430514 | 20431-20433 |
| ORF1ab/nsp15A1-B | 271 | M271I | M6723I | nonsyn | atG | atC | 2648 | 22 | 0.00830816 | 20431-20433 |
Details of the mutation M271I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1486 | 2648 | All | 0.000284 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1140 | 2648 | All | 0.000218 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 22 | 2648 | All | 0.000004 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 658 | 660 | AP.1 | 0.987988 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 660 | AP.1 | 0.003003 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 481 | 533 | B.1.1.7 | 0.000431 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 47 | 533 | B.1.1.7 | 0.000042 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 5 | 533 | B.1.1.7 | 0.000004 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 188 | 228 | AY.4 | 0.000293 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 40 | 228 | AY.4 | 0.000062 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 131 | 131 | AY.4.5 | 0.014081 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 50 | 96 | B.1.617.2 | 0.000188 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 46 | 96 | B.1.617.2 | 0.000173 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 81 | 81 | AY.62 | 0.035294 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 41 | 68 | AY.43 | 0.000182 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 27 | 68 | AY.43 | 0.00012 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 52 | 68 | B.1.2 | 0.000458 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 12 | 68 | B.1.2 | 0.000106 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 68 | B.1.2 | 0.000035 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 61 | 62 | B.1.575 | 0.018507 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 62 | B.1.575 | 0.000303 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 49 | 57 | AY.103 | 0.000304 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 8 | 57 | AY.103 | 0.00005 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 48 | 49 | B.1.1.222 | 0.009792 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 49 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 47 | 47 | P.1.15 | 0.01092 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 25 | 41 | AY.47 | 0.000778 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 16 | 41 | AY.47 | 0.000498 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 37 | 37 | B.1.1.432 | 0.046835 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 21 | 33 | B.1 | 0.000192 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 11 | 33 | B.1 | 0.000101 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 1 | 33 | B.1 | 0.000009 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 31 | 31 | AY.36 | 0.004595 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 21 | 29 | AY.25 | 0.000126 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 8 | 29 | AY.25 | 0.000048 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 24 | 24 | A.2.5.1 | 0.115385 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 21 | 23 | AY.98.1 | 0.001017 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 23 | AY.98.1 | 0.000097 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 18 | 21 | AY.3 | 0.000179 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 3 | 21 | AY.3 | 0.00003 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 20 | 20 | B.1.160 | 0.000624 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 11 | 19 | AY.44 | 0.000067 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 7 | 19 | AY.44 | 0.000043 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 1 | 19 | AY.44 | 0.000006 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 14 | 15 | AY.102 | 0.000371 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 15 | AY.102 | 0.000027 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 15 | 15 | AY.4.2 | 0.000325 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 12 | 14 | P.1 | 0.000189 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 14 | P.1 | 0.000032 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 8 | 13 | B.1.1 | 0.000145 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 13 | B.1.1 | 0.000073 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 1 | 13 | B.1.1 | 0.000018 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 7 | 10 | B.1.177 | 0.000092 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 3 | 10 | B.1.177 | 0.00004 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 10 | 10 | B.1.369 | 0.002852 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 7 | 9 | AY.39 | 0.000173 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 9 | AY.39 | 0.000049 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 5 | 8 | AY.5 | 0.000103 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 8 | AY.5 | 0.000062 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 6 | 8 | AY.9.2 | 0.00022 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 8 | AY.9.2 | 0.000073 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 8 | 8 | Q.8 | 0.001319 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 6 | 6 | AY.4.1 | 0.004425 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 6 | 6 | B.1.177.36 | 0.096774 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 5 | 6 | B.1.621 | 0.000443 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 6 | B.1.621 | 0.000089 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 5 | AY.29 | 0.000063 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 5 | AY.29 | 0.000016 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 5 | AY.37 | 0.001264 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 5 | AY.37 | 0.000316 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 4 | 4 | AY.20 | 0.000155 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 4 | 4 | AY.46.6 | 0.000289 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 4 | 4 | AY.9.1 | 0.000335 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 4 | 4 | B.1.258.7 | 0.007648 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 4 | B.1.351 | 0.000059 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 4 | B.1.351 | 0.000059 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 4 | 4 | B.1.356 | 0.006908 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 4 | B.1.637 | 0.000292 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 4 | 4 | D.2 | 0.0003 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 3 | AY.100 | 0.000092 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 3 | AY.100 | 0.000046 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 3 | AY.23 | 0.000139 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 3 | AY.23 | 0.00007 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 3 | AY.26 | 0.000057 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 3 | AY.26 | 0.000028 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 3 | 3 | AY.39.1 | 0.000119 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 3 | AY.46.4 | 0.000329 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 3 | AY.46.4 | 0.000165 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 3 | 3 | B.1.1.436 | 0.076923 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 3 | B.1.258 | 0.000133 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 3 | B.1.258 | 0.000067 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 3 | B.1.36 | 0.000292 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 3 | B.1.36 | 0.000146 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 3 | B.1.36.8 | 0.003 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 3 | B.1.632 | 0.020134 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 3 | 3 | P.2 | 0.00056 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 3 | 3 | Q.1 | 0.000379 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 2 | AY.117 | 0.000085 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 2 | AY.117 | 0.000085 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | AY.84 | 0.000875 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | AY.99.2 | 0.000184 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | B.1.1.244 | 0.030769 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | B.1.1.33 | 0.000842 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 2 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 2 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 2 | B.1.1.58 | 0.010753 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | B.1.399 | 0.003868 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | B.1.429 | 0.000047 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 2 | 2 | N.9 | 0.011905 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | 0.055556 | |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.34.1 | 0.00051 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.57 | 0.000656 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.60 | 0.000938 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | AY.99.1 | 0.001553 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.101 | 0.01 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.217 | 0.003636 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.305 | 0.003861 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.482 | 0.023256 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.526 | 0.003546 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.1.98 | 0.018519 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.142 | 0.002899 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.160.8 | 0.001289 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.177.41 | 0.0025 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.177.60 | 0.000218 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.258.11 | 0.000396 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.260 | 0.003344 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.336 | 0.002439 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.408 | 0.00369 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.1.499 | 0.00105 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.597 | 0.00463 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.3.1 | 0.001658 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | B.39 | 0.002331 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | N.5 | 0.001767 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atT | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atA | 1 | 1 | Q.7 | 0.001111 |
| ORF1ab/nsp15A1-B | 271 | M271I | atG | atC | 1 | 1 | W.4 | 0.001351 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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