CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = A217S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 217 | A217S | A6669S | nonsyn | Gct | Tct | 3553 | 3553 | 1 | 20269-20271 |
Details of the mutation A217S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3553 | 3553 | All | 0.00068 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1906 | 1906 | AY.6 | 0.078391 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 455 | 455 | B.1.1.7 | 0.000407 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 298 | 298 | AY.98.1 | 0.014432 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 141 | 141 | AY.4 | 0.000219 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 80 | 80 | B.1.617.2 | 0.000301 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 63 | 63 | AY.39 | 0.001557 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 61 | 61 | AY.102 | 0.001617 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 38 | 38 | AY.108 | 0.041896 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 34 | 34 | AY.120 | 0.001264 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 34 | 34 | AY.43 | 0.000151 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 34 | 34 | B.1.1.519 | 0.00135 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 33 | 33 | AY.103 | 0.000205 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 29 | 29 | AY.33 | 0.001937 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 22 | 22 | B.1.177 | 0.00029 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 21 | 21 | AY.13 | 0.003381 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 20 | 20 | B.1.177.60 | 0.004369 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 19 | 19 | AY.46.6 | 0.001372 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 18 | 18 | B.1.617.1 | 0.002321 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 16 | 16 | B.1.1 | 0.00029 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 16 | 16 | B.1.1.344 | 0.172043 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 14 | 14 | B.1 | 0.000128 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 13 | 13 | B.1.2 | 0.000114 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 9 | 9 | AY.25 | 0.000054 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 9 | 9 | AY.54 | 0.000858 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 8 | 8 | AY.121 | 0.001083 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 8 | 8 | AY.3 | 0.00008 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 8 | 8 | AY.5 | 0.000165 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 8 | 8 | B.1.1.193 | 0.888889 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 7 | 7 | AY.42 | 0.000282 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 7 | 7 | B.1.177.48 | 0.021875 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 6 | 6 | AY.23 | 0.000418 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 5 | 5 | AY.44 | 0.00003 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 4 | 4 | AY.3.1 | 0.000341 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 4 | 4 | B.1.1.419 | 0.02963 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 4 | 4 | B.1.240 | 0.000862 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 4 | 4 | B.1.36 | 0.000584 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.100 | 0.000138 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.26 | 0.000085 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.29 | 0.000047 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.5.3 | 0.001012 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | AY.98 | 0.000237 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 3 | 3 | B.1.1.231 | 0.009288 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.105 | 0.001286 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.111 | 0.000366 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.40 | 0.001929 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.46 | 0.000208 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.46.1 | 0.002053 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | AY.84 | 0.000875 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.1.117 | 0.019417 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.1.318 | 0.000604 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.1.372 | 0.001377 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.1.525 | 0.010929 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.258.11 | 0.000793 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.526 | 0.000047 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.621 | 0.000177 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | B.1.9.5 | 0.011364 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 2 | 2 | P.1.1 | 0.000635 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.34.1 | 0.00051 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.46.5 | 0.000198 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.58 | 0.000907 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.69 | 0.000187 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.7.1 | 0.000113 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.77 | 0.001127 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.79 | 0.001211 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.85 | 0.000427 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | AY.95 | 0.000761 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.1.386 | 0.066667 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.160.33 | 0.004425 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.177.77 | 0.000726 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.177.87 | 0.000728 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.36.29 | 0.000517 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.560 | 0.00463 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.582 | 0.000491 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | N.9 | 0.005952 |
| ORF1ab/nsp15A1-B | 217 | A217S | Gct | Tct | 1 | 1 | P.1.16 | 0.000374 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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