CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = V405V
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 405 | V405V | V6330V | syn | gtG | gtT | 848 | 667 | 0.786557 | 19252-19254 |
| ORF1ab/nsp14A2-B | 405 | V405V | V6330V | syn | gtG | gtA | 848 | 167 | 0.196934 | 19252-19254 |
| ORF1ab/nsp14A2-B | 405 | V405V | V6330V | syn | gtG | gtC | 848 | 14 | 0.0165094 | 19252-19254 |
Details of the mutation V405V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 667 | 848 | All | 0.000128 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 167 | 848 | All | 0.000032 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 14 | 848 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 278 | 278 | B.1.1.253 | 0.696742 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 63 | 86 | AY.4 | 0.000098 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 18 | 86 | AY.4 | 0.000028 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 5 | 86 | AY.4 | 0.000008 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 35 | 58 | B.1.1.7 | 0.000031 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 23 | 58 | B.1.1.7 | 0.000021 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 37 | 52 | B.1.617.2 | 0.000139 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 14 | 52 | B.1.617.2 | 0.000053 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 52 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 39 | 42 | AY.44 | 0.000237 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 3 | 42 | AY.44 | 0.000018 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 20 | 34 | AY.43 | 0.000089 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 14 | 34 | AY.43 | 0.000062 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 24 | 33 | AY.25 | 0.000144 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 9 | 33 | AY.25 | 0.000054 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 20 | 20 | L.4 | 1 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 16 | 17 | AY.103 | 0.000099 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 17 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 10 | 11 | B.1.177 | 0.000132 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 11 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 5 | 9 | AY.5 | 0.000103 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 4 | 9 | AY.5 | 0.000083 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 9 | 9 | B.1.404 | 0.011719 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 5 | 8 | B.1 | 0.000046 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 2 | 8 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 8 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 8 | 8 | B.1.1 | 0.000145 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 6 | 8 | P.1 | 0.000095 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 2 | 8 | P.1 | 0.000032 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 7 | 7 | B.1.243 | 0.000487 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 6 | 6 | AY.33 | 0.000401 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 5 | 6 | AY.47 | 0.000156 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 6 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 4 | 6 | B.1.526 | 0.000094 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 6 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 6 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 5 | 5 | AY.46.6 | 0.000361 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 3 | 5 | B.1.2 | 0.000026 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 5 | B.1.2 | 0.000018 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 5 | 5 | B.1.351.3 | 0.004382 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 4 | 5 | B.1.36 | 0.000584 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 5 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 5 | 5 | P.1.14 | 0.000239 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 4 | 4 | AY.74 | 0.000463 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 4 | 4 | B.1.320 | 0.004981 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 3 | 3 | A.2 | 0.001985 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | AY.121 | 0.000406 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | AY.70 | 0.000626 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | AY.84 | 0.001312 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | AY.99.2 | 0.000276 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | B.1.187 | 0.1 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 3 | 3 | B.1.525 | 0.000339 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.100 | 0.000092 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.104 | 0.003968 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 2 | 2 | AY.114 | 0.000462 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.119 | 0.000071 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 2 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 2 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 2 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 2 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.39 | 0.000049 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 2 | AY.42 | 0.00004 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 2 | AY.42 | 0.00004 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 2 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 2 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.88 | 0.001768 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.89 | 0.009804 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | AY.9.1 | 0.000167 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | B.1.1.329 | 0.007692 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 2 | B.1.177.54 | 0.000606 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 2 | B.1.177.54 | 0.000606 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 2 | 2 | B.1.426 | 0.002018 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | Q.1 | 0.000253 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 2 | 2 | R.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | A.23.1 | 0.000704 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | AY.101 | 0.00049 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.21 | 0.001898 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.7.1 | 0.000113 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.86 | 0.00083 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | AY.95 | 0.000761 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.1.10 | 0.001115 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.1.315 | 0.008475 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.177.23 | 0.003236 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.235 | 0.002519 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.391 | 0.001127 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | B.1.400 | 0.000429 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.524 | 0.001406 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.548 | 0.035714 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtC | 1 | 1 | B.40 | 0.000364 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtA | 1 | 1 | C.30 | 0.001727 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | C.36.3 | 0.000567 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp14A2-B | 405 | V405V | gtG | gtT | 1 | 1 | P.2 | 0.000187 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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