CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = V182I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 182 | V182I | V6107I | nonsyn | Gta | Ata | 2373 | 2372 | 0.999579 | 18583-18585 |
| ORF1ab/nsp14A2-B | 182 | V182I | V6107I | nonsyn | GtA | AtT | 2373 | 1 | 0.000421407 | 18583-18585 |
Details of the mutation V182I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2372 | 2373 | All | 0.000454 |
| ORF1ab/nsp14A2-B | 182 | V182I | GtA | AtT | 1 | 2373 | All | 0 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 341 | 341 | AY.4 | 0.000531 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 332 | 332 | B.1.617.2 | 0.00125 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 197 | 197 | AY.44 | 0.001199 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 184 | 184 | B.1.36.1 | 0.209806 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 153 | 154 | B.1.1.7 | 0.000137 |
| ORF1ab/nsp14A2-B | 182 | V182I | GtA | AtT | 1 | 154 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 152 | 152 | AY.43 | 0.000673 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 120 | 120 | AY.5 | 0.002478 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 119 | 119 | B.1.258.12 | 0.937008 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 115 | 115 | AY.25 | 0.000692 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 51 | 51 | AY.39 | 0.00126 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 37 | 37 | AY.26 | 0.001047 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 33 | 33 | AY.103 | 0.000205 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 30 | 30 | AY.83 | 0.051724 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 24 | 24 | AY.118 | 0.001504 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 22 | 22 | P.1 | 0.000347 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 20 | 20 | AY.20 | 0.000777 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 20 | 20 | B.1.575 | 0.006068 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 19 | 19 | AY.36 | 0.002816 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 19 | 19 | B.1.177.44 | 0.00986 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 19 | 19 | B.1.2 | 0.000167 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 17 | 17 | B.1.240 | 0.003665 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 16 | 16 | B.1.1 | 0.00029 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 15 | 15 | AY.102 | 0.000398 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 14 | 14 | AY.9.1 | 0.001172 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 13 | 13 | AY.120 | 0.000483 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 12 | 12 | AY.23 | 0.000837 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 12 | 12 | AY.3 | 0.000119 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 11 | 11 | B.1.526 | 0.000259 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 9 | 9 | B.1.539 | 0.157895 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | AY.46 | 0.000833 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | AY.89 | 0.039216 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | B.1 | 0.000073 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | B.1.1.519 | 0.000318 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | B.1.177.75 | 0.008325 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 8 | 8 | B.1.499 | 0.008403 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 7 | 7 | AY.100 | 0.000322 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 7 | 7 | AY.47 | 0.000218 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 7 | 7 | AY.8 | 0.004242 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 6 | 6 | AY.110 | 0.000676 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 6 | 6 | AY.117 | 0.000507 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 6 | 6 | AY.4.2 | 0.00013 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 6 | 6 | AY.98 | 0.000474 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 5 | 5 | AY.9.2 | 0.000184 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 5 | 5 | AY.98.1 | 0.000242 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 5 | 5 | R.1 | 0.00045 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | AY.119 | 0.000141 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | AY.33 | 0.000267 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | AY.39.1 | 0.000158 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | AY.45 | 0.000487 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | B.1.351 | 0.000119 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 4 | 4 | B.1.617.1 | 0.000516 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | A.23.1 | 0.002113 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | AY.106 | 0.001005 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | AY.46.6 | 0.000217 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.1.263 | 0.004673 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.1.434 | 0.001046 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.221 | 0.000213 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | B.1.637 | 0.000219 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 3 | 3 | P.1.4 | 0.00293 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.1 | 0.000791 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.113 | 0.000285 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.3.1 | 0.000171 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.4.4 | 0.000818 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.4.5 | 0.000215 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.42 | 0.00008 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.49 | 0.00639 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.72 | 0.002721 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.87 | 0.001665 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | B.1.1.216 | 0.001781 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | B.1.427 | 0.000101 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | B.1.621 | 0.000177 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 2 | 2 | P.1.10 | 0.000539 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.111 | 0.000183 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.4.3 | 0.000842 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.46.1 | 0.001027 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.65 | 0.000533 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.77 | 0.001127 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.1.39 | 0.00051 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.160.7 | 0.002079 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.177.11 | 0.001698 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.177.18 | 0.00116 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.177.77 | 0.000726 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.190 | 0.01 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.22 | 0.001318 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.279 | 0.000514 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.416.1 | 0.001563 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.498 | 0.020408 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.509 | 0.000866 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.1.630 | 0.005236 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | B.40 | 0.000364 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | C.16 | 0.00106 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 182 | V182I | Gta | Ata | 1 | 1 | P.2 | 0.000187 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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