CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = P443S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 443 | P443S | P6368S | nonsyn | Cca | Tca | 2595 | 2595 | 1 | 19366-19368 |
Details of the mutation P443S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2595 | 2595 | All | 0.000496 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1327 | 1327 | B.1.1.7 | 0.001188 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 301 | 301 | P.1 | 0.004742 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 207 | 207 | AY.42 | 0.008328 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 79 | 79 | AY.4 | 0.000123 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 43 | 43 | B.1.617.2 | 0.000162 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 34 | 34 | B.1.177.86 | 0.006237 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 31 | 31 | B.1.1 | 0.000562 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 29 | 29 | AY.103 | 0.00018 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 24 | 24 | AY.6 | 0.000987 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 24 | 24 | B.1.2 | 0.000211 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 22 | 22 | AY.14 | 0.001936 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 22 | 22 | B.1.177.60 | 0.004806 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 20 | 20 | AY.25 | 0.00012 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 20 | 20 | B.1 | 0.000183 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 19 | 19 | AY.3 | 0.000189 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 18 | 18 | AY.44 | 0.00011 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 17 | 17 | B.1.429 | 0.0004 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 15 | 15 | A.2 | 0.009927 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 14 | 14 | B | 0.001789 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 13 | 13 | AY.100 | 0.000598 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 12 | 12 | B.1.1.255 | 0.036364 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 10 | 10 | AY.43 | 0.000044 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 10 | 10 | AZ.1 | 0.008673 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 10 | 10 | B.1.177 | 0.000132 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 10 | 10 | C.5 | 0.909091 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 10 | 10 | P.1.12 | 0.00484 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 9 | 9 | AY.46.6 | 0.00065 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 9 | 9 | B.1.351 | 0.000268 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 9 | 9 | D.2 | 0.000675 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 7 | 7 | AY.47 | 0.000218 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 6 | 6 | AY.29 | 0.000095 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 6 | 6 | AY.5 | 0.000124 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 6 | 6 | AY.75.1 | 0.001082 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 6 | 6 | B.1.1.222 | 0.001224 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 6 | 6 | B.1.160 | 0.000187 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 5 | 5 | B.1.1.519 | 0.000199 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 5 | 5 | B.1.243 | 0.000348 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 5 | 5 | C.37 | 0.00058 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 5 | 5 | L.1 | 0.009524 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | AY.119 | 0.000141 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | AY.26 | 0.000113 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | AY.61 | 0.000419 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | B.1.160.9 | 0.028777 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | B.1.234 | 0.000528 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | B.1.258 | 0.000266 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | B.1.375 | 0.003279 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 4 | 4 | B.1.427 | 0.000202 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | AY.30 | 0.001187 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.1.348 | 0.002389 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.221 | 0.000213 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.453 | 0.009709 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.621 | 0.000266 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | B.1.628 | 0.001057 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 3 | 3 | Q.1 | 0.000379 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AU.3 | 0.004219 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.113 | 0.000285 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.39 | 0.000049 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.1.216 | 0.001781 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.1.318 | 0.000604 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.1.351 | 0.005587 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.1.83 | 0.00542 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.177.7 | 0.00033 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.241 | 0.001623 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.258.17 | 0.000208 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.36.38 | 0.003284 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | B.1.398 | 0.005952 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | Q.3 | 0.00029 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | Q.4 | 0.00091 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | Q.7 | 0.002222 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 2 | 2 | Q.8 | 0.00033 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | A.2.2 | 0.001689 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | A.2.5.1 | 0.004808 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | A.2.5.2 | 0.001572 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AE.1 | 0.011364 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.111 | 0.000183 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | AY.94 | 0.000443 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.176 | 0.000439 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.263 | 0.001558 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.279 | 0.001121 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.289 | 0.002083 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.389 | 0.006061 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.523 | 0.001563 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.55 | 0.012987 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.1.59 | 0.006494 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.126 | 0.001276 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.170 | 0.00431 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.11 | 0.001698 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.16 | 0.000664 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.50 | 0.004695 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.54 | 0.000606 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.61 | 0.043478 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.62 | 0.001192 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.177.79 | 0.002342 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.214.2 | 0.0006 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.236 | 0.002053 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.362.2 | 0.004717 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.367 | 0.000792 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.400 | 0.000429 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.568 | 0.001111 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.588 | 0.00091 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | N.4 | 0.004255 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | P.1.7 | 0.000319 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | P.2 | 0.000187 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | R.1 | 0.00009 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | R.2 | 0.014493 |
| ORF1ab/nsp14A2-B | 443 | P443S | Cca | Tca | 1 | 1 | W.4 | 0.001351 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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