CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = P443L
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 443 | P443L | P6368L | nonsyn | cCa | cTa | 454 | 453 | 0.997797 | 19366-19368 |
| ORF1ab/nsp14A2-B | 443 | P443L | P6368L | nonsyn | cCA | cTG | 454 | 1 | 0.00220264 | 19366-19368 |
Details of the mutation P443L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 453 | 454 | All | 0.000087 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCA | cTG | 1 | 454 | All | 0 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 99 | 99 | B.1.1.7 | 0.000089 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 39 | 39 | AY.103 | 0.000242 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 30 | 30 | B.1.617.2 | 0.000113 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 25 | 25 | AY.4 | 0.000039 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 23 | 23 | B.1.478 | 0.270588 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 21 | 21 | B.1.1.176 | 0.009227 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 17 | 17 | AY.43 | 0.000075 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 15 | 15 | B.1.429 | 0.000353 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 15 | 15 | P.1 | 0.000236 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 14 | 14 | B.1 | 0.000128 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 14 | 14 | B.1.177 | 0.000184 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 10 | 10 | B.1.1.294 | 0.012658 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 9 | 9 | B.1.2 | 0.000079 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 8 | 8 | B.1.221 | 0.000568 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 6 | 6 | AY.30 | 0.002374 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 5 | 5 | B.1.258.14 | 0.004902 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 4 | 4 | AY.25 | 0.000024 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 4 | 4 | B.1.623 | 0.002146 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | AY.26 | 0.000085 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | AY.34 | 0.000291 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | AY.44 | 0.000018 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | B.1.1.189 | 0.004539 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | B.1.1.89 | 0.018182 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | B.1.356 | 0.005181 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 3 | 3 | P.1.17 | 0.000485 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 443 | P443L | cCA | cTG | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.100 | 0.000092 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.37 | 0.000632 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.39 | 0.000049 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | AY.9.2 | 0.000073 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | B.1.1.277 | 0.001517 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | B.1.1.411 | 0.029412 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 2 | 2 | B.1.526 | 0.000047 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | A.18 | 0.05 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | A.2.5.2 | 0.001572 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.69 | 0.000187 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.7.2 | 0.000559 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.79 | 0.001211 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.1.115 | 0.008929 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.1.157 | 0.000913 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.1.301 | 0.001179 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.177.86 | 0.000183 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.241 | 0.000812 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.324 | 0.001605 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.351.3 | 0.000876 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.351.5 | 0.0006 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.36.8 | 0.001 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.480 | 0.002488 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.517 | 0.000427 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp14A2-B | 443 | P443L | cCa | cTa | 1 | 1 | C.36 | 0.000911 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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