CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = P412H
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 412 | P412H | P6337H | nonsyn | cCt | cAt | 11842 | 11836 | 0.999493 | 19273-19275 |
| ORF1ab/nsp14A2-B | 412 | P412H | P6337H | nonsyn | cCT | cAC | 11842 | 6 | 0.000506671 | 19273-19275 |
Details of the mutation P412H within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 11836 | 11842 | All | 0.002264 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCT | cAC | 6 | 11842 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 11063 | 11069 | R.1 | 0.99577 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCT | cAC | 6 | 11069 | R.1 | 0.00054 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 228 | 228 | B.1.1 | 0.004136 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 101 | 101 | B.1.1.220 | 0.187732 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 80 | 80 | B.1 | 0.000733 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 46 | 46 | AY.25 | 0.000277 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 34 | 34 | AY.43 | 0.000151 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 33 | 33 | B.1.1.525 | 0.180328 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 26 | 26 | B.1.1.7 | 0.000023 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 21 | 21 | AY.4 | 0.000033 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 16 | 16 | B.1.617.2 | 0.00006 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 15 | 15 | B.1.1.317 | 0.006175 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 12 | 12 | B.1.1.10 | 0.013378 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 12 | 12 | B.1.416 | 0.015228 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 11 | 11 | AY.27 | 0.000712 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 11 | 11 | AY.99.2 | 0.001014 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 9 | 9 | AY.45 | 0.001095 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 7 | 7 | AY.30 | 0.00277 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 6 | 6 | AY.71 | 0.00285 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 5 | 5 | B.1.1.222 | 0.00102 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 5 | 5 | B.1.2 | 0.000044 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 4 | 4 | AY.44 | 0.000024 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | AY.101 | 0.001471 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | AY.103 | 0.000019 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | AY.39 | 0.000074 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | B.1.1.39 | 0.001529 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 3 | 3 | B.1.1.521 | 0.016043 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | A | 0.000774 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | AY.33 | 0.000134 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B | 0.000256 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.1.291 | 0.001485 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.1.51 | 0.003436 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.1.83 | 0.00542 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.575 | 0.000607 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | B.1.577 | 0.001375 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | A.2.4 | 0.003367 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.111 | 0.000183 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.77 | 0.001127 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | AY.93 | 0.000273 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.196 | 0.005714 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.198 | 0.001468 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.236 | 0.006897 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.263 | 0.001558 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.305 | 0.003861 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.464 | 0.001473 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.1.8 | 0.003584 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.161 | 0.017241 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.177.84 | 0.006667 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.265 | 0.001271 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.301 | 0.005917 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.351.3 | 0.000876 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.389 | 0.001002 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.436 | 0.001029 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.468 | 0.005714 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.533 | 0.009615 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.543 | 0.01 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 412 | P412H | cCt | cAt | 1 | 1 | B.1.623 | 0.000536 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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