CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = P203P
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 203 | P203P | P6128P | syn | ccT | ccC | 622 | 331 | 0.532154 | 18646-18648 |
| ORF1ab/nsp14A2-B | 203 | P203P | P6128P | syn | ccT | ccA | 622 | 179 | 0.287781 | 18646-18648 |
| ORF1ab/nsp14A2-B | 203 | P203P | P6128P | syn | ccT | ccG | 622 | 112 | 0.180064 | 18646-18648 |
Details of the mutation P203P within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 331 | 622 | All | 0.000063 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 179 | 622 | All | 0.000034 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 112 | 622 | All | 0.000021 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 148 | 148 | B.1.177.82 | 0.070644 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 111 | 120 | AY.44 | 0.000676 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 7 | 120 | AY.44 | 0.000043 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 2 | 120 | AY.44 | 0.000012 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 48 | 51 | AY.100 | 0.002208 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 51 | AY.100 | 0.000092 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 51 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 21 | 39 | B.1.617.2 | 0.000079 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 15 | 39 | B.1.617.2 | 0.000056 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 3 | 39 | B.1.617.2 | 0.000011 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 30 | 38 | B.1.1.7 | 0.000027 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 5 | 38 | B.1.1.7 | 0.000004 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 3 | 38 | B.1.1.7 | 0.000003 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 19 | 22 | AY.3 | 0.000189 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 3 | 22 | AY.3 | 0.00003 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 18 | 19 | AY.3.1 | 0.001535 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 19 | AY.3.1 | 0.000085 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 10 | 19 | AY.4 | 0.000016 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 7 | 19 | AY.4 | 0.000011 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 2 | 19 | AY.4 | 0.000003 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 16 | 16 | A.2.5 | 0.007984 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 8 | 15 | B.1 | 0.000073 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 7 | 15 | B.1 | 0.000064 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 14 | 14 | AY.103 | 0.000087 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 10 | 10 | B.1.1.214 | 0.000555 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 10 | 10 | B.1.1.519 | 0.000397 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 8 | 9 | B.1.160 | 0.00025 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 9 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 5 | 8 | AY.43 | 0.000022 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 2 | 8 | AY.43 | 0.000009 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 8 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 4 | 5 | B.1.1.284 | 0.00043 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 5 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 5 | 5 | P.2 | 0.000933 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 4 | 4 | AY.25 | 0.000024 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | A.21 | 0.00831 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 2 | 3 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 3 | AY.102 | 0.000027 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 3 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 3 | AY.29 | 0.000016 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | AY.9.2 | 0.00011 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 3 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 3 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | B.1.1.207 | 0.003546 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | B.1.177 | 0.00004 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | B.1.526 | 0.000071 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | AY.54 | 0.000191 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | AY.55 | 0.001835 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | AD.2 | 0.000219 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | AY.29.1 | 0.000221 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.50 | 0.000799 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | AY.69 | 0.000187 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.1.231 | 0.003096 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.1.523 | 0.001563 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.177.77 | 0.000726 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.260 | 0.003344 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.351.3 | 0.000876 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.356 | 0.001727 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 1 | B.1.393 | 0.028571 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.416 | 0.001269 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.543 | 0.01 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.577 | 0.000687 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccA | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccC | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp14A2-B | 203 | P203P | ccT | ccG | 1 | 1 | P.1 | 0.000016 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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