CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = M501del
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 501 | M501del | M6426del | del | ATG | --- | 675 | 675 | 1 | 19540-19542 |
Details of the mutation M501del within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 675 | 675 | All | 0.000129 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 160 | 160 | AY.43 | 0.000709 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 65 | 65 | B.1.2 | 0.000572 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 45 | 45 | B.1.1.7 | 0.00004 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 45 | 45 | B.1.617.2 | 0.000169 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 29 | 29 | AY.25 | 0.000174 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 21 | 21 | AY.34.1 | 0.010709 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 21 | 21 | B.1 | 0.000192 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 15 | 15 | AY.44 | 0.000091 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 13 | 13 | AY.3 | 0.000129 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 12 | 12 | B.1.351 | 0.000357 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 11 | 11 | AY.9.2 | 0.000404 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 11 | 11 | B.1.526 | 0.000259 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 10 | 10 | AY.103 | 0.000062 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 10 | 10 | AY.39 | 0.000247 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 9 | 9 | AY.75 | 0.000504 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 8 | 8 | AY.4 | 0.000012 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 8 | 8 | AY.52 | 0.006515 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 8 | 8 | AY.98.1 | 0.000387 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 7 | 7 | AY.102 | 0.000186 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 7 | 7 | B.1.596 | 0.00061 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 6 | 6 | 0.333333 | |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 6 | 6 | B.1.1 | 0.000109 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 5 | 5 | AY.118 | 0.000313 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 5 | 5 | AY.23 | 0.000349 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 5 | 5 | AY.42 | 0.000201 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 5 | 5 | B.1.429 | 0.000118 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | AY.11 | 0.005355 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | AY.110 | 0.000451 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | AY.3.1 | 0.000341 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | AY.65 | 0.002132 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | B.1.243 | 0.000278 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 4 | 4 | B.1.617.1 | 0.000516 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | AY.101 | 0.001471 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | AY.119 | 0.000106 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | AY.85 | 0.001282 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | B.1.1.218 | 0.023077 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | B.1.265 | 0.003812 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 3 | 3 | B.1.36 | 0.000438 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.107 | 0.000932 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.33 | 0.000134 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.5.4 | 0.000553 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.55 | 0.001835 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.9.1 | 0.000167 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.97 | 0.003401 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | AY.99.2 | 0.000184 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.1.416 | 0.00181 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.349 | 0.00143 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.517 | 0.000854 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.568 | 0.002222 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 2 | 2 | P.1.15 | 0.000465 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.108 | 0.001103 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.120.2 | 0.001285 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.21 | 0.001898 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.7.2 | 0.000559 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.78 | 0.001541 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.94 | 0.000443 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | AY.99 | 0.001049 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.174 | 0.003378 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.192 | 0.002309 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.207 | 0.001182 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.348 | 0.000796 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.409 | 0.002833 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.1.46 | 0.004367 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.177.62 | 0.001192 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.291 | 0.019231 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.36.31 | 0.001751 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.395 | 0.007042 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.409 | 0.000781 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.416.1 | 0.001563 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.439 | 0.005917 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.471 | 0.002732 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.551 | 0.00129 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | C.1.2 | 0.004255 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp14A2-B | 501 | M501del | ATG | --- | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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