CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = M501T
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 501 | M501T | M6426T | nonsyn | aTg | aCg | 1138 | 1132 | 0.994728 | 19540-19542 |
| ORF1ab/nsp14A2-B | 501 | M501T | M6426T | nonsyn | aTG | aCA | 1138 | 4 | 0.00351494 | 19540-19542 |
| ORF1ab/nsp14A2-B | 501 | M501T | M6426T | nonsyn | aTG | aCT | 1138 | 2 | 0.00175747 | 19540-19542 |
Details of the mutation M501T within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1132 | 1138 | All | 0.000217 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCA | 4 | 1138 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCT | 2 | 1138 | All | 0 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 400 | 400 | AY.114 | 0.092443 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 204 | 204 | AY.4 | 0.000318 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 100 | 100 | AY.33 | 0.006678 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 86 | 88 | B.1.1.7 | 0.000077 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCA | 2 | 88 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 48 | 48 | AY.44 | 0.000292 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 44 | 46 | B.1.617.2 | 0.000166 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCA | 1 | 46 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCT | 1 | 46 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 35 | 36 | AY.119 | 0.001236 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCA | 1 | 36 | AY.119 | 0.000035 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 25 | 25 | AY.43 | 0.000111 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 14 | 14 | AY.32 | 0.007455 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 14 | 14 | B.1.2 | 0.000123 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 11 | 12 | AY.103 | 0.000068 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTG | aCT | 1 | 12 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 11 | 11 | B.1 | 0.000101 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 11 | 11 | B.1.177 | 0.000145 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 11 | 11 | B.1.177.9 | 0.014647 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 9 | 9 | AY.102 | 0.000239 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 8 | 8 | B.1.234 | 0.001056 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 5 | 5 | AY.25 | 0.00003 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 5 | 5 | AY.3 | 0.00005 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 5 | 5 | AY.5.3 | 0.001687 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 5 | 5 | B.1.429 | 0.000118 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 4 | 4 | AY.46 | 0.000416 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 4 | 4 | AY.46.6 | 0.000289 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | AY.120.2.1 | 0.001495 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | AY.4.3 | 0.002525 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | B.1.177.40 | 0.015464 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 3 | 3 | P.1.11 | 0.030612 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.47 | 0.000062 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.75 | 0.000112 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | AY.99.2 | 0.000184 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | B.1.313 | 0.013158 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | B.1.8 | 0.003945 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | P.5 | 0.027397 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 2 | 2 | Q.1 | 0.000253 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.110 | 0.000113 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.116.1 | 0.000311 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.5.4 | 0.000277 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.1.416 | 0.000905 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.177.38 | 0.010417 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.36.29 | 0.000517 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | P.1 | 0.000016 |
| ORF1ab/nsp14A2-B | 501 | M501T | aTg | aCg | 1 | 1 | P.1.3 | 0.034483 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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