CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = M169I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 169 | M169I | M6094I | nonsyn | atG | atT | 2362 | 2256 | 0.955123 | 18544-18546 |
| ORF1ab/nsp14A2-B | 169 | M169I | M6094I | nonsyn | atG | atA | 2362 | 97 | 0.0410669 | 18544-18546 |
| ORF1ab/nsp14A2-B | 169 | M169I | M6094I | nonsyn | atG | atC | 2362 | 9 | 0.00381033 | 18544-18546 |
Details of the mutation M169I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2256 | 2362 | All | 0.000431 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 97 | 2362 | All | 0.000019 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 9 | 2362 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 568 | 570 | B.1.1.7 | 0.000508 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 2 | 570 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 459 | 459 | C.36 | 0.418033 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 259 | 262 | AY.4 | 0.000403 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 3 | 262 | AY.4 | 0.000005 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 141 | 141 | AY.43 | 0.000625 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 82 | 95 | B.1.2 | 0.000722 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 12 | 95 | B.1.2 | 0.000106 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 1 | 95 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 68 | 68 | B.1.617.2 | 0.000256 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 44 | 53 | AY.103 | 0.000273 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 9 | 53 | AY.103 | 0.000056 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 45 | 45 | B.1.243.2 | 0.652174 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 44 | 45 | P.1 | 0.000693 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 45 | P.1 | 0.000016 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 40 | 41 | AY.44 | 0.000243 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 41 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 33 | 33 | B.1.1.519 | 0.00131 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 32 | 33 | R.1 | 0.00288 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 33 | R.1 | 0.00009 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 32 | 32 | B.1.160 | 0.000998 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 31 | 31 | AY.3 | 0.000308 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 27 | 27 | B.1 | 0.000247 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 20 | 23 | AY.25 | 0.00012 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 2 | 23 | AY.25 | 0.000012 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 23 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 20 | 20 | AY.9.2 | 0.000735 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 18 | 18 | B.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 17 | 17 | AY.102 | 0.000451 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 16 | 16 | AY.42 | 0.000644 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 16 | 16 | B.1.404 | 0.020833 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 16 | 16 | B.1.526 | 0.000376 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 12 | 12 | B.1.617.1 | 0.001548 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 7 | 9 | AY.29 | 0.00011 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 2 | 9 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 9 | 9 | AY.75 | 0.000504 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 8 | 8 | AY.75.1 | 0.001442 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 8 | 8 | B.1.429 | 0.000188 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 7 | 7 | AY.14 | 0.000616 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 7 | 7 | AY.39 | 0.000173 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 7 | B.1.177 | 0.000066 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 1 | 7 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 7 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 7 | 7 | B.1.177.57 | 0.001967 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 6 | 6 | B | 0.000767 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 6 | B.1.1.316 | 0.004625 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 6 | B.1.1.316 | 0.000925 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 6 | 6 | C.17 | 0.333333 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | AY.3.1 | 0.000426 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | AY.5 | 0.000103 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | AY.57 | 0.003281 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | AY.6 | 0.000206 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 5 | 5 | B.1.160.26 | 0.012107 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | B.1.258 | 0.000333 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 5 | B.1.36.29 | 0.001552 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 2 | 5 | B.1.36.29 | 0.001035 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 5 | B.1.621 | 0.000354 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 5 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 5 | 5 | P.2 | 0.000933 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | AY.87 | 0.003331 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | B.1.177.85 | 0.021739 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | B.1.279 | 0.002054 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | B.1.36 | 0.000584 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | B.1.628 | 0.001409 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | C.37 | 0.000464 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 4 | 4 | C.39 | 0.075472 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | AY.119 | 0.000106 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | AY.12 | 0.000948 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 2 | 3 | AY.26 | 0.000057 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 3 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 3 | 3 | AY.69 | 0.00056 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 3 | 3 | B.1.595 | 0.000783 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.27 | 0.000129 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.39.1 | 0.000079 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.41 | 0.000588 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 2 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 2 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.7.1 | 0.000225 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.73 | 0.001331 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.74 | 0.000231 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.84 | 0.000875 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.1.28 | 0.000622 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 2 | 2 | B.1.1.306 | 0.000877 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.1.354 | 0.008772 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.177.86 | 0.000367 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.214.2 | 0.001199 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.239 | 0.002442 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.346 | 0.002621 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 2 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 2 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.466.2 | 0.000782 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | B.1.470 | 0.002809 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 2 | 2 | P.1.17 | 0.000324 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 2 | Q.8 | 0.000165 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atA | 1 | 2 | Q.8 | 0.000165 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | A.2.2 | 0.001689 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AA.2 | 0.007692 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.15 | 0.002222 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atC | 1 | 1 | AY.19 | 0.00114 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.22 | 0.002092 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.4.4 | 0.000409 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.5.2 | 0.002463 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.5.4 | 0.000277 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | AY.94 | 0.000443 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.198 | 0.001468 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.274 | 0.005051 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.277 | 0.000759 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.362 | 0.005618 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.369 | 0.000446 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.432 | 0.001266 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.110.3 | 0.000718 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.127 | 0.002198 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.177.21 | 0.000076 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.177.32 | 0.00135 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.192 | 0.009259 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.265 | 0.001271 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.336 | 0.002439 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.362 | 0.001541 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.416 | 0.001269 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.428 | 0.00102 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.575.1 | 0.002439 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.617.3 | 0.002985 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.1.630 | 0.005236 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | B.4.5 | 0.011905 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | C.1 | 0.002392 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | C.16 | 0.00106 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | P.1.10 | 0.000269 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp14A2-B | 169 | M169I | atG | atT | 1 | 1 | Q.3 | 0.000145 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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