CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = K47K
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 47 | K47K | K5972K | syn | aaG | aaA | 1280 | 1280 | 1 | 18178-18180 |
Details of the mutation K47K within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1280 | 1280 | All | 0.000245 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 430 | 430 | B.1.36.27 | 0.328244 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 166 | 166 | AY.4 | 0.000258 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 149 | 149 | B.1.1.7 | 0.000133 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 82 | 82 | B.1.429 | 0.001929 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 72 | 72 | B.1.36 | 0.010505 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 48 | 48 | AY.25 | 0.000289 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 37 | 37 | B.1.1.328 | 0.627119 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 28 | 28 | B.1 | 0.000256 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 28 | 28 | R.1 | 0.00252 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 23 | 23 | AY.44 | 0.00014 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 17 | 17 | P.1.15 | 0.00395 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 16 | 16 | P.1 | 0.000252 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 15 | 15 | B.1.2 | 0.000132 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 14 | 14 | B.1.617.2 | 0.000053 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 11 | 11 | B.1.1.214 | 0.00061 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 10 | 10 | AY.39 | 0.000247 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 8 | 8 | AY.43 | 0.000035 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 7 | 7 | AY.5.3 | 0.002362 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 7 | 7 | B.1.1 | 0.000127 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 6 | 6 | AY.103 | 0.000037 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 6 | 6 | B.1.1.10 | 0.006689 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 6 | 6 | B.1.1.519 | 0.000238 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 4 | 4 | AY.20 | 0.000155 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 4 | 4 | AY.26 | 0.000113 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 4 | 4 | AY.59 | 0.002119 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 4 | 4 | B.1.621 | 0.000354 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | AY.102 | 0.00008 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | AY.9.1 | 0.000251 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | B.1.177.32 | 0.004049 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | P.1.14 | 0.000143 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 3 | 3 | Q.1 | 0.000379 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.114 | 0.000462 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.42 | 0.00008 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | A.2.4 | 0.003367 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | A.5 | 0.001923 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.2 | 0.000356 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.68 | 0.000274 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.7.1 | 0.000113 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.1.181 | 0.004545 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.1.277 | 0.000759 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.1.389 | 0.006061 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.82 | 0.000477 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.83 | 0.001481 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.177.9 | 0.001332 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.260 | 0.003344 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.351.2 | 0.000303 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.564.1 | 0.001577 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.1.599 | 0.00365 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.23 | 0.002924 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | B.3 | 0.000831 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | P.1.10 | 0.000269 |
| ORF1ab/nsp14A2-B | 47 | K47K | aaG | aaA | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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