CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = K304N
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 304 | K304N | K6229N | nonsyn | aaG | aaT | 1609 | 1597 | 0.992542 | 18949-18951 |
| ORF1ab/nsp14A2-B | 304 | K304N | K6229N | nonsyn | aaG | aaC | 1609 | 12 | 0.00745805 | 18949-18951 |
Details of the mutation K304N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1597 | 1609 | All | 0.000305 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 12 | 1609 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 648 | 648 | B.1.160 | 0.02021 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 145 | 145 | B.1.1.7 | 0.00013 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 123 | 125 | AY.4 | 0.000191 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 2 | 125 | AY.4 | 0.000003 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 93 | 93 | P.1 | 0.001465 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 65 | 65 | B.1.617.2 | 0.000245 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 43 | 43 | AY.13 | 0.006922 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 38 | 38 | AY.5 | 0.000785 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 38 | 38 | B.1.2 | 0.000335 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 27 | 27 | AY.25 | 0.000162 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 22 | 23 | AY.3 | 0.000219 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 23 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 23 | 23 | B.1 | 0.000211 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 23 | 23 | B.1.177 | 0.000303 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 19 | 19 | B.1.160.13 | 0.527778 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 19 | 19 | B.1.427 | 0.000959 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 18 | 18 | AY.43 | 0.00008 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 14 | 14 | B.1.617.1 | 0.001806 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 13 | 13 | AY.98 | 0.001027 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 11 | 12 | AY.44 | 0.000067 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 12 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 11 | 11 | AY.4.2 | 0.000239 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 10 | 10 | B.1.526 | 0.000235 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 10 | 10 | D.2 | 0.00075 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 9 | 9 | AY.102 | 0.000239 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 8 | 8 | AY.119 | 0.000282 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 7 | 7 | B.1.36.27 | 0.005344 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 6 | AY.39 | 0.000124 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 6 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 6 | 6 | AY.99.2 | 0.000553 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 6 | 6 | C.37 | 0.000696 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | AY.103 | 0.000031 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | AY.47 | 0.000156 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | B.1.1 | 0.000091 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | B.1.311 | 0.001373 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | B.1.351 | 0.000149 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | B.1.36 | 0.00073 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 5 | 5 | Q.1 | 0.000632 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 4 | AY.26 | 0.000085 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 4 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 4 | 4 | AY.75 | 0.000224 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 4 | 4 | B.1.1.216 | 0.003562 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | AY.3.1 | 0.000256 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 2 | 3 | AY.30 | 0.000791 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 3 | AY.30 | 0.000396 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | AY.39.1 | 0.000119 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | AY.46.6 | 0.000217 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | AY.9 | 0.000203 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | B.1.1.12 | 0.022388 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | B.1.221 | 0.000213 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | B.1.438.1 | 0.000322 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 3 | 3 | B.1.497 | 0.000944 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.100 | 0.000092 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.14 | 0.000176 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.42 | 0.00008 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.46.1 | 0.002053 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | AY.9.1 | 0.000167 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | B.1.1.306 | 0.000877 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | B.1.1.386 | 0.133333 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | B.1.177.81 | 0.000379 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | B.1.499 | 0.002101 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | B.1.525 | 0.000226 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 2 | 2 | P.1.11 | 0.020408 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.57 | 0.000656 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.65 | 0.000533 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.95 | 0.000761 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.258 | 0.003257 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaC | 1 | 1 | B.1.1.291 | 0.000742 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.307 | 0.002532 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.364 | 0.066667 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.1.366 | 0.015873 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.189 | 0.004292 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.239 | 0.001221 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.471 | 0.002732 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.473 | 0.019231 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.580 | 0.004065 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.605 | 0.005952 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.1.623 | 0.000536 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | C.1 | 0.002392 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | C.36.3 | 0.000567 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | Q.3 | 0.000145 |
| ORF1ab/nsp14A2-B | 304 | K304N | aaG | aaT | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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