CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = I74V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp14A2-B74I74VI5999VnonsynAtcGtc9599540.99478618259-18261
ORF1ab/nsp14A2-B74I74VI5999VnonsynAtCGtG95940.0041710118259-18261
ORF1ab/nsp14A2-B74I74VI5999VnonsynAtCGtT95910.0010427518259-18261

Details of the mutation I74V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp14A2-B74I74VAtcGtc954959All0.000182
ORF1ab/nsp14A2-B74I74VAtCGtG4959All0.000001
ORF1ab/nsp14A2-B74I74VAtCGtT1959All0
ORF1ab/nsp14A2-B74I74VAtcGtc236236AY.40.000367
ORF1ab/nsp14A2-B74I74VAtcGtc103103B.1.1.70.000092
ORF1ab/nsp14A2-B74I74VAtcGtc8383B.1.1.1700.103491
ORF1ab/nsp14A2-B74I74VAtcGtc7979B.1.177.200.119879
ORF1ab/nsp14A2-B74I74VAtcGtc7171A.210.196676
ORF1ab/nsp14A2-B74I74VAtcGtc5353C.350.041022
ORF1ab/nsp14A2-B74I74VAtcGtc3939AY.440.000237
ORF1ab/nsp14A2-B74I74VAtcGtc3232B.1.1.3280.542373
ORF1ab/nsp14A2-B74I74VAtcGtc3132B.1.617.20.000117
ORF1ab/nsp14A2-B74I74VAtCGtG132B.1.617.20.000004
ORF1ab/nsp14A2-B74I74VAtcGtc2323B.1.3990.044487
ORF1ab/nsp14A2-B74I74VAtcGtc1616AY.30.000159
ORF1ab/nsp14A2-B74I74VAtcGtc1616B.1.160.310.129032
ORF1ab/nsp14A2-B74I74VAtcGtc1112B.10.000101
ORF1ab/nsp14A2-B74I74VAtCGtG112B.10.000009
ORF1ab/nsp14A2-B74I74VAtcGtc1010B.1.20.000088
ORF1ab/nsp14A2-B74I74VAtcGtc99AY.1140.00208
ORF1ab/nsp14A2-B74I74VAtcGtc99AY.200.00035
ORF1ab/nsp14A2-B74I74VAtcGtc88AY.260.000226
ORF1ab/nsp14A2-B74I74VAtcGtc88AY.290.000126
ORF1ab/nsp14A2-B74I74VAtcGtc77AY.250.000042
ORF1ab/nsp14A2-B74I74VAtcGtc77B.1.3200.008717
ORF1ab/nsp14A2-B74I74VAtcGtc66AY.430.000027
ORF1ab/nsp14A2-B74I74VAtcGtc55AY.1190.000177
ORF1ab/nsp14A2-B74I74VAtcGtc55P.10.000079
ORF1ab/nsp14A2-B74I74VAtcGtc44B.1.1.3170.001647
ORF1ab/nsp14A2-B74I74VAtcGtc44B.1.4270.000202
ORF1ab/nsp14A2-B74I74VAtcGtc44B.1.6280.001409
ORF1ab/nsp14A2-B74I74VAtcGtc33AY.1020.00008
ORF1ab/nsp14A2-B74I74VAtcGtc33AY.20.001068
ORF1ab/nsp14A2-B74I74VAtcGtc33AY.4.20.000065
ORF1ab/nsp14A2-B74I74VAtcGtc12AY.1130.000142
ORF1ab/nsp14A2-B74I74VAtCGtG12AY.1130.000142
ORF1ab/nsp14A2-B74I74VAtcGtc22AY.1160.000574
ORF1ab/nsp14A2-B74I74VAtcGtc22AY.390.000049
ORF1ab/nsp14A2-B74I74VAtcGtc22AY.460.000208
ORF1ab/nsp14A2-B74I74VAtcGtc22AY.50.000041
ORF1ab/nsp14A2-B74I74VAtCGtT12AY.840.000437
ORF1ab/nsp14A2-B74I74VAtCGtG12AY.840.000437
ORF1ab/nsp14A2-B74I74VAtcGtc22B.1.10.000036
ORF1ab/nsp14A2-B74I74VAtcGtc22B.1.1.10.000653
ORF1ab/nsp14A2-B74I74VAtcGtc22B.1.258.120.015748
ORF1ab/nsp14A2-B74I74VAtcGtc22B.1.5260.000047
ORF1ab/nsp14A2-B74I74VAtcGtc22B.1.617.10.000258
ORF1ab/nsp14A2-B74I74VAtcGtc22P.1.140.000096
ORF1ab/nsp14A2-B74I74VAtcGtc11A0.000387
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.1000.000046
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.1030.000006
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.1170.000085
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.1180.000063
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.120.20.001285
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.3.10.000085
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.34.10.00051
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.360.000148
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.380.000499
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.420.00004
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.46.60.000072
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.470.000031
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.540.000095
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.550.000917
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.650.000533
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.70.000196
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.750.000056
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.9.10.000084
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.98.10.000048
ORF1ab/nsp14A2-B74I74VAtcGtc11AY.99.20.000092
ORF1ab/nsp14A2-B74I74VAtcGtc11AZ.40.003356
ORF1ab/nsp14A2-B74I74VAtcGtc11B0.000128
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.2770.000759
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.2910.000742
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.3720.000689
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.3890.006061
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.5070.008696
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.550.012987
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.1.560.017857
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.2100.002132
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.2580.000067
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.258.170.000104
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.3020.013333
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.360.000146
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.36.100.004785
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.36.170.000494
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.4280.00102
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.4950.009091
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.5090.000866
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.5250.000113
ORF1ab/nsp14A2-B74I74VAtcGtc11B.1.5750.000303
ORF1ab/nsp14A2-B74I74VAtcGtc11C.370.000116
ORF1ab/nsp14A2-B74I74VAtcGtc11Q.10.000126
ORF1ab/nsp14A2-B74I74VAtcGtc11W.10.008696

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.