CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = D222Y
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 222 | D222Y | D6147Y | nonsyn | Gac | Tac | 717 | 716 | 0.998605 | 18703-18705 |
| ORF1ab/nsp14A2-B | 222 | D222Y | D6147Y | nonsyn | GaC | TaT | 717 | 1 | 0.0013947 | 18703-18705 |
Details of the mutation D222Y within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 716 | 717 | All | 0.000137 |
| ORF1ab/nsp14A2-B | 222 | D222Y | GaC | TaT | 1 | 717 | All | 0 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 109 | 109 | B.1.1.7 | 0.000098 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 69 | 69 | B.1.617.2 | 0.00026 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 68 | 68 | AY.103 | 0.000422 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 55 | 55 | AY.75 | 0.003081 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 46 | 46 | AY.70 | 0.009591 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 40 | 40 | AY.4 | 0.000062 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 35 | 35 | D.2 | 0.002626 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 24 | 24 | B.1.2 | 0.000211 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 21 | 21 | B.1.1 | 0.000381 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 14 | 14 | AY.25 | 0.000084 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 14 | 14 | B.1.1.242 | 0.608696 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 12 | 12 | AY.44 | 0.000073 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 11 | 11 | AY.43 | 0.000049 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 10 | 10 | AY.3 | 0.000099 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 9 | 9 | B.1.1.348 | 0.007166 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 8 | 8 | AY.102 | 0.000212 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 6 | 6 | P.1 | 0.000095 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | AY.120 | 0.000186 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | AY.13 | 0.000805 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | AY.29 | 0.000079 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | AY.54 | 0.000477 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | AY.98.1 | 0.000242 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | B.1 | 0.000046 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 5 | 5 | B.1.366 | 0.02439 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | AY.20 | 0.000155 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | AY.71 | 0.0019 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | AY.91 | 0.002922 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | B.1.177.87 | 0.002911 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 4 | 4 | B.1.351.5 | 0.002398 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | AY.100 | 0.000138 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | AY.4.4 | 0.001227 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.1.519 | 0.000119 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.177.7 | 0.000495 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.36 | 0.000438 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.516 | 0.005871 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.526 | 0.000071 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | B.1.621.1 | 0.001517 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 3 | 3 | L.3 | 0.010638 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.116 | 0.000574 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.59 | 0.001059 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.7.1 | 0.000225 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | AY.9.2 | 0.000073 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.1.214 | 0.000111 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.362.2 | 0.009434 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.427 | 0.000101 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.525 | 0.000226 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.535 | 0.057143 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.561 | 0.000794 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 2 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 222 | D222Y | GaC | TaT | 1 | 2 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | A.2 | 0.000662 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.1 | 0.000396 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.107 | 0.000466 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.108 | 0.001103 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.111 | 0.000183 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.24 | 0.000431 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.60 | 0.000938 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.1.382 | 0.035714 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.377 | 0.004566 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.589 | 0.007576 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | D.3 | 0.005917 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | P.1.4 | 0.000977 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | P.1.7 | 0.000319 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | Q.3 | 0.000145 |
| ORF1ab/nsp14A2-B | 222 | D222Y | Gac | Tac | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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