CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = D222E

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp14A2-B	222	D222E	D6147E	nonsyn	gaC	gaA	21	15	0.714286	18703-18705
ORF1ab/nsp14A2-B	222	D222E	D6147E	nonsyn	gaC	gaG	21	6	0.285714	18703-18705

Details of the mutation D222E within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp14A2-B	222	D222E	gaC	gaA	15	21	All	0.000003
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	6	21	All	0.000001
ORF1ab/nsp14A2-B	222	D222E	gaC	gaA	8	8	B.1.577	0.005498
ORF1ab/nsp14A2-B	222	D222E	gaC	gaA	4	4	B.1.1.7	0.000004
ORF1ab/nsp14A2-B	222	D222E	gaC	gaA	2	2	AY.25	0.000012
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	2	2	B.1.351.3	0.001753
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	1	1	AY.73	0.000665
ORF1ab/nsp14A2-B	222	D222E	gaC	gaA	1	1	B.1.2	0.000009
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	1	1	B.1.258.11	0.000396
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	1	1	B.1.596	0.000087
ORF1ab/nsp14A2-B	222	D222E	gaC	gaG	1	1	B.1.617.1	0.000129

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.