CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = D222A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp14A2-B	222	D222A	D6147A	nonsyn	gAc	gCc	29	28	0.965517	18703-18705
ORF1ab/nsp14A2-B	222	D222A	D6147A	nonsyn	gAC	gCA	29	1	0.0344828	18703-18705

Details of the mutation D222A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	28	29	All	0.000005
ORF1ab/nsp14A2-B	222	D222A	gAC	gCA	1	29	All	0
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	10	10	AY.25	0.00006
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	4	4	B.1.258.17	0.000416
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	3	3	B.1.1.7	0.000003
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	2	2	AY.4	0.000003
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	2	2	B.1.258	0.000133
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	2	2	B.1.329	0.001215
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	2	2	B.1.617.2	0.000008
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	1	1	AY.11	0.001339
ORF1ab/nsp14A2-B	222	D222A	gAC	gCA	1	1	AY.43	0.000004
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	1	1	AY.99.2	0.000092
ORF1ab/nsp14A2-B	222	D222A	gAc	gCc	1	1	Q.1	0.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.