CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = D126del

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp14A2-B	126	D126del	D6051del	del	GAT	---	46	46	1	18415-18417

Details of the mutation D126del within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp14A2-B	126	D126del	GAT	---	46	46	All	0.000009
ORF1ab/nsp14A2-B	126	D126del	GAT	---	17	17	AY.25	0.000102
ORF1ab/nsp14A2-B	126	D126del	GAT	---	10	10	B.1.1.7	0.000009
ORF1ab/nsp14A2-B	126	D126del	GAT	---	5	5	AY.43	0.000022
ORF1ab/nsp14A2-B	126	D126del	GAT	---	5	5	B.1.617.2	0.000019
ORF1ab/nsp14A2-B	126	D126del	GAT	---	2	2	B.1.1	0.000036
ORF1ab/nsp14A2-B	126	D126del	GAT	---	2	2	B.1.2	0.000018
ORF1ab/nsp14A2-B	126	D126del	GAT	---	1	1	AY.120	0.000037
ORF1ab/nsp14A2-B	126	D126del	GAT	---	1	1	AY.53	0.000288
ORF1ab/nsp14A2-B	126	D126del	GAT	---	1	1	AY.9.2	0.000037
ORF1ab/nsp14A2-B	126	D126del	GAT	---	1	1	B.1.177.9	0.001332
ORF1ab/nsp14A2-B	126	D126del	GAT	---	1	1	Q.2	0.000613

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.