CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = D126D
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 126 | D126D | D6051D | syn | gaT | gaC | 4678 | 4678 | 1 | 18415-18417 |
Details of the mutation D126D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4678 | 4678 | All | 0.000895 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1948 | 1948 | A.2.5 | 0.972056 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 624 | 624 | A.2.5.2 | 0.981132 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 483 | 483 | B.1.1.7 | 0.000432 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 259 | 259 | AY.4 | 0.000403 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 208 | 208 | A.2.5.1 | 1 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 136 | 136 | B.1.2 | 0.001198 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 121 | 121 | B.1.617.2 | 0.000456 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 96 | 96 | AY.43 | 0.000425 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 91 | 91 | A.2.5.3 | 0.938144 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 60 | 60 | AY.25 | 0.000361 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 49 | 49 | AY.14 | 0.004313 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 33 | 33 | B.1.599 | 0.120438 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 32 | 32 | AY.103 | 0.000199 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 32 | 32 | AY.3 | 0.000318 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 27 | 27 | AY.47 | 0.00084 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 26 | 26 | AY.44 | 0.000158 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 26 | 26 | B.1 | 0.000238 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 22 | 22 | AY.120.2.1 | 0.010962 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 20 | 20 | AY.46 | 0.002082 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 18 | 18 | AY.99.2 | 0.001659 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 15 | 15 | B.1.177 | 0.000198 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 15 | 15 | B.1.369 | 0.004278 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 14 | 14 | P.1 | 0.000221 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 13 | 13 | AY.4.5 | 0.001397 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 13 | 13 | B.1.1.434 | 0.004531 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 12 | 12 | B.1.429 | 0.000282 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 11 | 11 | AY.48 | 0.005116 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 11 | 11 | B.1.160 | 0.000343 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 10 | 10 | B.1.1 | 0.000181 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 9 | 9 | B.1.596 | 0.000784 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 8 | 8 | B.1.1.37 | 0.001543 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 8 | 8 | B.1.1.519 | 0.000318 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 8 | 8 | B.1.526 | 0.000188 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 7 | 7 | AY.4.2 | 0.000152 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 7 | 7 | C.37 | 0.000812 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 6 | 6 | AY.102 | 0.000159 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 6 | 6 | AY.3.1 | 0.000512 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 6 | 6 | AY.35 | 0.001398 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 6 | 6 | B.1.1.518 | 0.037975 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 6 | 6 | P.1.11 | 0.061224 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 5 | 5 | AY.75 | 0.00028 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 5 | 5 | AY.9.2 | 0.000184 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 5 | 5 | B.1.351 | 0.000149 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 5 | 5 | B.1.78 | 0.042735 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 5 | 5 | P.1.7 | 0.001596 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.108 | 0.00441 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.120 | 0.000149 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.20 | 0.000155 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.45 | 0.000487 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.92 | 0.001149 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | AY.99.1 | 0.006211 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | B | 0.000511 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | B.1.433 | 0.01278 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 4 | 4 | P.1.8 | 0.019139 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | AY.29 | 0.000047 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | AY.5 | 0.000062 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | AY.7.2 | 0.001678 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | B.1.234 | 0.000396 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 3 | 3 | Q.8 | 0.000495 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.121 | 0.000271 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.16.1 | 0.00094 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.26 | 0.000057 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.39 | 0.000049 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.239 | 0.002442 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.356 | 0.003454 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.36 | 0.000292 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.470 | 0.002809 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.617.1 | 0.000258 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | B.1.637 | 0.000146 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | A.2 | 0.000662 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | A.2.4 | 0.003367 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.19 | 0.00114 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.22 | 0.002092 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.23.1 | 0.000417 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.31 | 0.018519 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.73 | 0.000665 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.79 | 0.001211 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.85 | 0.000427 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | AY.99 | 0.001049 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.220 | 0.001859 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.265 | 0.003155 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.277 | 0.000759 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.302 | 0.002075 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.318 | 0.000302 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.326 | 0.001761 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.348 | 0.000796 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.524 | 0.020833 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.1.63 | 0.000386 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.157 | 0.002985 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.177.82 | 0.000477 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.324 | 0.001605 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.416.1 | 0.001563 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.517 | 0.000427 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.582 | 0.000491 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.627 | 0.00202 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.1.629 | 0.013333 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | C.30 | 0.001727 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 126 | D126D | gaT | gaC | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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