CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = A85S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 85 | A85S | A6010S | nonsyn | Gca | Tca | 5236 | 5236 | 1 | 18292-18294 |
Details of the mutation A85S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 5236 | 5236 | All | 0.001001 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3825 | 3825 | AY.4 | 0.005953 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 477 | 477 | B.1.236 | 0.979466 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 150 | 150 | C.2.1 | 1 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 98 | 98 | AY.42 | 0.003943 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 82 | 82 | B.1.617.2 | 0.000309 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 62 | 62 | B.1.1.7 | 0.000056 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 61 | 61 | C.2 | 0.983871 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 53 | 53 | B.1 | 0.000485 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 48 | 48 | AY.43 | 0.000213 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 31 | 31 | B.1.118 | 0.208054 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 22 | 22 | AY.103 | 0.000137 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 20 | 20 | AY.39 | 0.000494 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 20 | 20 | B.1.160 | 0.000624 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 16 | 16 | B.1.158 | 0.380952 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 12 | 12 | B.1.526 | 0.000282 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 11 | 11 | AY.44 | 0.000067 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 11 | 11 | AY.66 | 0.011765 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 10 | 10 | AY.25 | 0.00006 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 10 | 10 | B.1.1 | 0.000181 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 9 | 9 | AY.102 | 0.000239 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 9 | 9 | AY.26 | 0.000255 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 9 | 9 | B.1.177.60 | 0.001966 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 8 | 8 | AY.46.6 | 0.000578 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 7 | 7 | B.1.1.1 | 0.002287 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 7 | 7 | B.1.427 | 0.000353 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 6 | 6 | AY.20 | 0.000233 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 6 | 6 | B.1.1.70 | 0.002046 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 6 | 6 | B.1.177.43 | 0.008863 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 6 | 6 | B.1.2 | 0.000053 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 6 | 6 | B.1.36 | 0.000875 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 5 | 5 | AY.120.1 | 0.001605 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 5 | 5 | AY.37 | 0.00158 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 5 | 5 | B.1.177 | 0.000066 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 4 | 4 | AY.3 | 0.00004 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 4 | 4 | P.1 | 0.000063 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3 | 3 | AY.53 | 0.000863 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3 | 3 | AY.68 | 0.000821 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3 | 3 | B.1.36.8 | 0.003 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 3 | 3 | B.1.621 | 0.000266 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AE.1 | 0.022727 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.113 | 0.000285 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.23 | 0.000139 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.33 | 0.000134 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.7.1 | 0.000225 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | AY.99.2 | 0.000184 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B | 0.000256 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.1.153 | 0.002191 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.1.28 | 0.000622 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.1.306 | 0.000877 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.1.50 | 0.001358 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.147 | 0.001512 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.177.23 | 0.006472 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.459 | 0.008163 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.525 | 0.000226 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.621.1 | 0.001012 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | B.1.623 | 0.001073 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | C.35 | 0.001548 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 2 | 2 | L.3 | 0.007092 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | A.2.5.2 | 0.001572 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.22 | 0.002092 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.5.4 | 0.000277 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.63 | 0.000387 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.80 | 0.001129 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.86 | 0.00083 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.90 | 0.000684 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.161 | 0.003534 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.274 | 0.005051 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.348 | 0.000796 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.39 | 0.00051 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.1.83 | 0.00271 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.126 | 0.001276 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.146 | 0.004237 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.177.42 | 0.000894 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.177.53 | 0.002392 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.233 | 0.014085 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.36.39 | 0.002217 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.398 | 0.002976 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.404 | 0.001302 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.466 | 0.023256 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.538 | 0.008065 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.587 | 0.001898 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.588.1 | 0.038462 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 85 | A85S | Gca | Tca | 1 | 1 | P.1.10 | 0.000269 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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