CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = A504A
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 504 | A504A | A6429A | syn | gcT | gcC | 491 | 347 | 0.706721 | 19549-19551 |
| ORF1ab/nsp14A2-B | 504 | A504A | A6429A | syn | gcT | gcA | 491 | 96 | 0.195519 | 19549-19551 |
| ORF1ab/nsp14A2-B | 504 | A504A | A6429A | syn | gcT | gcG | 491 | 48 | 0.0977597 | 19549-19551 |
Details of the mutation A504A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 347 | 491 | All | 0.000066 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 96 | 491 | All | 0.000018 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 48 | 491 | All | 0.000009 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 262 | 270 | B.1.1.7 | 0.000235 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 5 | 270 | B.1.1.7 | 0.000004 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 3 | 270 | B.1.1.7 | 0.000003 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 10 | 20 | AY.43 | 0.000044 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 7 | 20 | AY.43 | 0.000031 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 3 | 20 | AY.43 | 0.000013 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 9 | 20 | B.1.2 | 0.000079 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 6 | 20 | B.1.2 | 0.000053 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 5 | 20 | B.1.2 | 0.000044 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 10 | 16 | AY.4 | 0.000016 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 4 | 16 | AY.4 | 0.000006 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 16 | AY.4 | 0.000003 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 5 | 10 | B.1 | 0.000046 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 4 | 10 | B.1 | 0.000037 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 10 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 4 | 9 | AY.102 | 0.000106 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 3 | 9 | AY.102 | 0.00008 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 9 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 8 | 9 | AY.119 | 0.000282 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 9 | AY.119 | 0.000035 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 4 | 7 | B.1.139 | 0.002933 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 2 | 7 | B.1.139 | 0.001466 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 7 | B.1.139 | 0.000733 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 4 | 6 | AY.103 | 0.000025 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 6 | AY.103 | 0.000012 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 3 | 6 | AY.3 | 0.00003 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 6 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 6 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 4 | 6 | AY.44 | 0.000024 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 6 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 6 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 5 | 6 | AY.47 | 0.000156 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 6 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 6 | 6 | AY.74 | 0.000694 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 4 | 6 | B.1.617.2 | 0.000015 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 6 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 5 | 5 | AY.14 | 0.00044 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 2 | 5 | AY.46.6 | 0.000144 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 5 | AY.46.6 | 0.000144 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 5 | AY.46.6 | 0.000072 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 4 | C.37 | 0.000232 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 4 | C.37 | 0.000232 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 3 | 3 | AY.25 | 0.000018 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 2 | 3 | AY.46 | 0.000208 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 3 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 3 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 3 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 3 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 3 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 3 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 3 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | A.2.2 | 0.003378 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 2 | AY.121 | 0.000271 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 2 | AY.13 | 0.000161 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 2 | AY.13 | 0.000161 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 2 | AY.23 | 0.000139 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | AY.45 | 0.000243 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 2 | AY.85 | 0.000427 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 2 | AY.85 | 0.000427 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | B.1.1.216 | 0.001781 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | B.1.239 | 0.002442 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 2 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 2 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 2 | 2 | B.1.429 | 0.000047 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 2 | B.1.470 | 0.002809 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 2 | C.14 | 0.004329 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 2 | C.14 | 0.004329 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | A.2.4 | 0.003367 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | A.3 | 0.002096 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.107 | 0.000466 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | AY.120.2.1 | 0.000498 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 1 | AY.21 | 0.001898 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | AY.39.2 | 0.001541 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.7.2 | 0.000559 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.87 | 0.000833 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.99.1 | 0.001553 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | AZ.2 | 0.000821 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.1.219 | 0.005 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.1.507 | 0.008696 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.258.11 | 0.000396 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.291 | 0.019231 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.306 | 0.005714 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.501 | 0.007353 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.551 | 0.00129 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.599 | 0.00365 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcA | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | B.1.619.1 | 0.000641 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcC | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 504 | A504A | gcT | gcG | 1 | 1 | P.6 | 0.003145 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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