CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = A323S
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 323 | A323S | A6248S | nonsyn | Gca | Tca | 29939 | 29937 | 0.999933 | 19006-19008 |
| ORF1ab/nsp14A2-B | 323 | A323S | A6248S | nonsyn | GcA | TcC | 29939 | 2 | 0.0000668025 | 19006-19008 |
Details of the mutation A323S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 29937 | 29939 | All | 0.005726 |
| ORF1ab/nsp14A2-B | 323 | A323S | GcA | TcC | 2 | 29939 | All | 0 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 26252 | 26252 | AY.119 | 0.926912 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2711 | 2711 | B.1.617.2 | 0.010208 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 268 | 268 | AY.44 | 0.001631 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 69 | 69 | AY.25 | 0.000415 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 69 | 69 | AY.4 | 0.000107 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 52 | 52 | AY.43 | 0.00023 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 51 | 51 | B.1.1.7 | 0.000046 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 51 | 51 | B.1.243 | 0.003549 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 36 | 36 | B.1 | 0.00033 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 29 | 29 | B.1.1 | 0.000526 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 26 | 26 | AY.4.2 | 0.000564 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 24 | 24 | D.2 | 0.001801 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 16 | 16 | B | 0.002045 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 15 | 15 | AY.4.5 | 0.001612 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 13 | 13 | AY.117 | 0.001099 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 12 | 12 | AY.92 | 0.003447 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 12 | 12 | B.1.258 | 0.000799 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 10 | 10 | B.1.2 | 0.000088 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 8 | 8 | AY.45 | 0.000973 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 8 | 8 | AY.46.6 | 0.000578 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 7 | 7 | AY.26 | 0.000198 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 7 | 7 | B.1.1.486 | 0.011041 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 7 | 7 | B.1.221 | 0.000497 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 7 | 7 | B.1.36 | 0.001021 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 6 | 6 | AY.103 | 0.000037 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 6 | 6 | AY.104 | 0.011905 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 6 | 6 | AY.3 | 0.00006 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 6 | 6 | AY.74 | 0.000694 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 6 | 6 | B.1.1.286 | 0.017391 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 5 | 5 | AY.113 | 0.000712 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 5 | 5 | AY.46 | 0.00052 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 5 | 5 | AY.47 | 0.000156 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 5 | 5 | B.1.177 | 0.000066 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 5 | 5 | P.1 | 0.000079 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 4 | 0.111111 | |
| ORF1ab/nsp14A2-B | 323 | A323S | GcA | TcC | 2 | 4 | 0.111111 | |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 4 | 4 | AY.36 | 0.000593 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 4 | 4 | AY.39.1 | 0.000158 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 4 | 4 | B.1.164 | 0.059701 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | AY.9.2 | 0.00011 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | AY.98 | 0.000237 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | B.1.1.33 | 0.001263 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | B.1.1.519 | 0.000119 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 3 | 3 | B.1.595 | 0.000783 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.33 | 0.000134 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.69 | 0.000373 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.9.1 | 0.000167 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | AY.95 | 0.001522 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.1.25 | 0.001137 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.1.356 | 0.017094 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.36.18 | 0.00084 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.369 | 0.00057 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.462 | 0.014493 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.539 | 0.035088 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | B.6 | 0.00182 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 2 | 2 | N.5 | 0.003534 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.11 | 0.001339 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.110 | 0.000113 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.35 | 0.000233 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.40 | 0.000964 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.82 | 0.001357 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | AY.93 | 0.000273 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.111 | 0.014706 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.121 | 0.002427 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.171 | 0.003676 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.320 | 0.018182 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.39 | 0.00051 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.1.416 | 0.000905 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.111 | 0.001175 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.170 | 0.00431 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.177.35 | 0.000691 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.252 | 0.006623 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.258.21 | 0.007752 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.260 | 0.003344 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.313 | 0.006579 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.36.24 | 0.006173 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.436 | 0.001029 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.453 | 0.003236 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.470 | 0.001404 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.527 | 0.003704 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.9 | 0.006173 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.1.9.4 | 0.006135 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | B.29 | 0.003509 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | C.14 | 0.004329 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | C.36 | 0.000911 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | D.3 | 0.005917 |
| ORF1ab/nsp14A2-B | 323 | A323S | Gca | Tca | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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