CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = A320V
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 320 | A320V | A6245V | nonsyn | gCa | gTa | 4218 | 4217 | 0.999763 | 18997-18999 |
| ORF1ab/nsp14A2-B | 320 | A320V | A6245V | nonsyn | gCA | gTG | 4218 | 1 | 0.000237079 | 18997-18999 |
Details of the mutation A320V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 4217 | 4218 | All | 0.000807 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCA | gTG | 1 | 4218 | All | 0 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1503 | 1504 | B.1 | 0.013767 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCA | gTG | 1 | 1504 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 943 | 943 | B.1.499 | 0.990546 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 394 | 394 | B.1.503 | 0.9801 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 290 | 290 | B.1.1.7 | 0.00026 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 225 | 225 | B.1.505 | 0.986842 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 153 | 153 | Q.8 | 0.025231 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 132 | 132 | B.1.501 | 0.970588 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 87 | 87 | B.1.507 | 0.977528 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 49 | 49 | B.1.498 | 1 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 39 | 39 | B.1.508 | 1 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 37 | 37 | B.1.506 | 0.880952 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 34 | 34 | AY.103 | 0.000211 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 30 | 30 | AY.20 | 0.001166 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 29 | 29 | B.1.504 | 0.90625 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 25 | 25 | B.1.615 | 1 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 24 | 24 | B.1.611 | 0.96 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 19 | 19 | B.1.502 | 1 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 14 | 14 | B.1.500 | 0.736842 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 13 | 13 | AY.118 | 0.000814 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 13 | 13 | B.1.177.60 | 0.00284 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 12 | 12 | B.1.177 | 0.000158 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 12 | 12 | B.1.617.2 | 0.000045 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 10 | 10 | AY.4 | 0.000016 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 9 | 9 | B.1.499.1 | 1 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 8 | 8 | B.1.160 | 0.00025 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 7 | 7 | B.1.1 | 0.000127 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 6 | 6 | AY.23 | 0.000418 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 5 | 5 | B.1.1.284 | 0.000537 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 5 | 5 | B.1.258 | 0.000333 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 5 | 5 | B.1.362 | 0.007704 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 4 | 4 | AY.25 | 0.000024 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 4 | 4 | AY.44 | 0.000024 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 4 | 4 | B.1.582 | 0.001963 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | AY.3 | 0.00003 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | B.1.2 | 0.000026 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | B.1.235 | 0.007557 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | B.1.367 | 0.002377 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | B.1.398 | 0.008929 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 3 | 3 | B.1.509 | 0.002597 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | AY.35 | 0.000466 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | AY.43 | 0.000009 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.1.526 | 0.007092 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.157 | 0.00597 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.237 | 0.00995 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.302 | 0.026667 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.391 | 0.002255 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.493 | 0.051282 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.68 | 0.000274 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.93 | 0.000273 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.1.335 | 0.012987 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.1.420 | 0.001006 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.1.433 | 0.001425 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.115 | 0.021739 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.140 | 0.018868 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.167 | 0.007812 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.316 | 0.111111 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.354 | 0.043478 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.428 | 0.00102 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.453 | 0.003236 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.601 | 0.030303 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.625 | 0.002353 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | B.1.9.5 | 0.005682 |
| ORF1ab/nsp14A2-B | 320 | A320V | gCa | gTa | 1 | 1 | P.1.10 | 0.000269 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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