CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : Mut = A220A
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 220 | A220A | A6145A | syn | gcT | gcC | 1716 | 868 | 0.505827 | 18697-18699 |
| ORF1ab/nsp14A2-B | 220 | A220A | A6145A | syn | gcT | gcG | 1716 | 835 | 0.486597 | 18697-18699 |
| ORF1ab/nsp14A2-B | 220 | A220A | A6145A | syn | gcT | gcA | 1716 | 13 | 0.00757576 | 18697-18699 |
Details of the mutation A220A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 868 | 1716 | All | 0.000166 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 835 | 1716 | All | 0.00016 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 13 | 1716 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 735 | 735 | AY.80 | 0.829571 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 667 | 706 | B.1.1.7 | 0.000597 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 37 | 706 | B.1.1.7 | 0.000033 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 2 | 706 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 95 | 102 | AY.4 | 0.000148 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 7 | 102 | AY.4 | 0.000011 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 17 | 20 | B.1.2 | 0.00015 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 3 | 20 | B.1.2 | 0.000026 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 5 | 10 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 5 | 10 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 4 | 8 | AY.43 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 8 | AY.43 | 0.000013 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 8 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 5 | 7 | AY.39 | 0.000124 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 2 | 7 | AY.39 | 0.000049 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 7 | 7 | B.1.258 | 0.000466 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 3 | 6 | AY.25 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 6 | AY.25 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 4 | 6 | AY.44 | 0.000024 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 2 | 6 | AY.44 | 0.000012 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 3 | 6 | B.1.36 | 0.000438 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 6 | B.1.36 | 0.000438 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 6 | 6 | P.1.7 | 0.001916 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 5 | AY.103 | 0.000019 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 5 | AY.103 | 0.000012 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 4 | 5 | B.1.160 | 0.000125 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 5 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 5 | 5 | B.1.509 | 0.004329 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 4 | 4 | B.1.221 | 0.000284 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 3 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 3 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 3 | AY.6 | 0.000123 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 3 | 3 | B.1.621.1 | 0.001517 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 3 | 3 | P.1 | 0.000047 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | A | 0.000774 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.46 | 0.000208 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.63 | 0.000774 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | AY.69 | 0.000373 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 2 | 2 | B.1.1.263 | 0.003115 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | B.1.177.4 | 0.000422 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 2 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 2 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 2 | 2 | B.1.637 | 0.000146 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 2 | 2 | P.2 | 0.000373 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | AY.35 | 0.000233 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | AY.4.3 | 0.000842 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.1.290 | 0.018182 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.1.512 | 0.028571 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 1 | B.1.177.59 | 0.016129 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.214.2 | 0.0006 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.258.11 | 0.000396 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.391 | 0.001127 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.521 | 0.004975 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcA | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | B.3 | 0.000831 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcG | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp14A2-B | 220 | A220A | gcT | gcC | 1 | 1 | Q.8 | 0.000165 |
 |
 |
CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
|