CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 83
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 83 | V83V | V6008V | syn | gtA | gtG | 188 | 179 | 0.952128 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83V | V6008V | syn | gtA | gtC | 188 | 6 | 0.0319149 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83V | V6008V | syn | gtA | gtT | 188 | 3 | 0.0159574 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83I | V6008I | nonsyn | Gta | Ata | 156 | 156 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83A | V6008A | nonsyn | gTa | gCa | 155 | 154 | 0.993548 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83A | V6008A | nonsyn | gTA | gCC | 155 | 1 | 0.00645161 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83L | V6008L | nonsyn | Gta | Tta | 67 | 67 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83del | V6008del | del | GTA | --- | 13 | 13 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83T | V6008T | nonsyn | GTA | ACC | 2 | 2 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83E | V6008E | nonsyn | gTa | gAa | 2 | 2 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83G | V6008G | nonsyn | gTa | gGa | 1 | 1 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83del2 | V6008del2 | del | gTA | g-- | 1 | 1 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83M | V6008M | nonsyn | GtA | AtG | 1 | 1 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83del1 | V6008del1 | del | Gta | -ta | 1 | 1 | 1 | 18286-18288 |
| ORF1ab/nsp14A2-B | 83 | V83F | V6008F | nonsyn | GtA | TtT | 1 | 1 | 1 | 18286-18288 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 179 | 188 | All | 0.000034 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 6 | 188 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtT | 3 | 188 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 156 | 156 | All | 0.00003 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 154 | 155 | All | 0.000029 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTA | gCC | 1 | 155 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 88 | 88 | B.1.630 | 0.460733 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 74 | 74 | B.1.177 | 0.000974 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 67 | 67 | All | 0.000013 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 61 | 61 | B.1.1.461 | 0.73494 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 43 | 44 | B.1.1.7 | 0.000038 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 44 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 38 | 38 | B.1.221 | 0.002699 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 31 | 32 | AY.4 | 0.000048 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 32 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 22 | 22 | B.1.1.7 | 0.00002 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 21 | 21 | B.1.1.7 | 0.000019 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 13 | 13 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 12 | 12 | B.1.218 | 0.061856 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 12 | 12 | B.1.369 | 0.003423 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 9 | 9 | B.1.177.85 | 0.048913 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 8 | 8 | AY.43 | 0.000035 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 8 | 8 | B.1.1.7 | 0.000007 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 7 | 7 | B.1.2 | 0.000062 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 6 | 6 | B.1.2 | 0.000053 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 5 | 6 | B.1.617.2 | 0.000019 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtT | 1 | 6 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 5 | 5 | AY.26 | 0.000142 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 5 | 5 | AY.3 | 0.00005 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 5 | 5 | AY.4 | 0.000008 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 4 | 4 | AY.47 | 0.000124 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 4 | 4 | B.1.351 | 0.000119 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 4 | 4 | P.1.17 | 0.000647 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 3 | 3 | AY.43 | 0.000013 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 3 | 3 | B.1 | 0.000027 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 3 | 3 | B.1.1.207 | 0.003546 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 3 | 3 | B.1.234 | 0.000396 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 3 | 3 | B.1.617.2 | 0.000011 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 3 | 3 | C.37 | 0.000348 |
| ORF1ab/nsp14A2-B | 83 | V83T | GTA | ACC | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83E | gTa | gAa | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 2 | 2 | AY.115 | 0.010417 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 2 | 2 | AY.25 | 0.000012 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 2 | 2 | AY.44 | 0.000012 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 2 | 2 | AY.63 | 0.000774 |
| ORF1ab/nsp14A2-B | 83 | V83T | GTA | ACC | 2 | 2 | B | 0.000256 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtT | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 2 | 2 | B.1.243 | 0.000139 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 2 | 2 | B.1.375 | 0.001639 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 2 | 2 | B.1.400 | 0.000858 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 2 | 2 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 2 | 2 | Q.1 | 0.000253 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | A.2.5.3 | 0.010309 |
| ORF1ab/nsp14A2-B | 83 | V83del1 | Gta | -ta | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83M | GtA | AtG | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83del2 | gTA | g-- | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83F | GtA | TtT | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83G | gTa | gGa | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp14A2-B | 83 | V83E | gTa | gAa | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 83 | V83M | GtA | AtG | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | AY.53 | 0.000288 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 83 | V83F | GtA | TtT | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 83 | V83E | gTa | gAa | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 83 | V83del | GTA | --- | 1 | 1 | B.1.1.139 | 0.022727 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.1.332 | 0.03125 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtT | 1 | 1 | B.1.1.416 | 0.000905 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp14A2-B | 83 | V83del2 | gTA | g-- | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.160.20 | 0.008929 |
| ORF1ab/nsp14A2-B | 83 | V83G | gTa | gGa | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtC | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.177.21 | 0.000076 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | B.1.177.43 | 0.001477 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.177.60 | 0.000218 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | B.1.232 | 0.000537 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 83 | V83del1 | Gta | -ta | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp14A2-B | 83 | V83I | Gta | Ata | 1 | 1 | B.1.427 | 0.00005 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTA | gCC | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.588 | 0.00091 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | C.29 | 0.0625 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp14A2-B | 83 | V83L | Gta | Tta | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 83 | V83A | gTa | gCa | 1 | 1 | P.1 | 0.000016 |
| ORF1ab/nsp14A2-B | 83 | V83V | gtA | gtG | 1 | 1 | P.1 | 0.000016 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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