CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 504 & Codon = gcC

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp14A2-B	504	A504A	A6429A	syn	gcT	gcC	491	347	0.706721	19549-19551

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	347	491	All	0.000066
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	262	270	B.1.1.7	0.000235
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	3	20	AY.43	0.000013
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	5	20	B.1.2	0.000044
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	10	16	AY.4	0.000016
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	5	10	B.1	0.000046
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	9	AY.102	0.000053
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	7	B.1.139	0.000733
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	4	6	AY.103	0.000025
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	6	AY.3	0.00002
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	6	AY.44	0.000006
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	6	AY.47	0.000031
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	6	6	AY.74	0.000694
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	4	6	B.1.617.2	0.000015
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	5	5	AY.14	0.00044
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	5	AY.46.6	0.000072
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	4	C.37	0.000232
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	3	AY.98.1	0.000048
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	3	B.1.1	0.000018
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	A.2.2	0.003378
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	2	AY.13	0.000161
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	AY.34	0.000194
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	AY.45	0.000243
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	2	AY.85	0.000427
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	B.1.1.216	0.001781
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	B.1.239	0.002442
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	2	B.1.427	0.00005
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	2	2	B.1.429	0.000047
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	2	C.14	0.004329
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	AY.120.2.1	0.000498
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	AY.20	0.000039
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	AY.39.2	0.001541
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	AY.4.2	0.000022
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	AY.6	0.000041
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.1.219	0.005
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.258.11	0.000396
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.291	0.019231
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.306	0.005714
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.36	0.000146
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.369	0.000285
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.501	0.007353
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.599	0.00365
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	B.1.619.1	0.000641
ORF1ab/nsp14A2-B	504	A504A	gcT	gcC	1	1	D.2	0.000075

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.