CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 504 & Codon = gTt
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 504 | A504V | A6429V | nonsyn | gCt | gTt | 433 | 427 | 0.986143 | 19549-19551 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 427 | 433 | All | 0.000082 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 83 | 83 | AY.4 | 0.000129 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 52 | 52 | B.1.1.7 | 0.000047 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 21 | 21 | AY.85 | 0.008971 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 17 | 17 | AY.103 | 0.000106 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 17 | 17 | B.1.561 | 0.006749 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 16 | 16 | B.1.1.70 | 0.005457 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 15 | 15 | AY.25 | 0.00009 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 14 | 14 | AY.4.2 | 0.000304 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 14 | 14 | B.1 | 0.000128 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 13 | 13 | B.1.2 | 0.000114 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 13 | 13 | P.1.7 | 0.004151 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 11 | 11 | B.1.617.2 | 0.000041 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 7 | 9 | AY.43 | 0.000031 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 7 | 8 | B.1.1 | 0.000127 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 6 | 6 | AY.44 | 0.000037 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 6 | 6 | AY.54 | 0.000572 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 6 | 6 | B.1.177.60 | 0.001311 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 5 | 5 | AY.3 | 0.00005 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 5 | 5 | AY.38 | 0.002496 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 5 | 5 | B.1.177 | 0.000066 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 5 | 5 | B.1.258.22 | 0.013333 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 4 | 4 | AY.39 | 0.000099 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 4 | 4 | AY.9.2 | 0.000147 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 3 | 3 | AY.9.1 | 0.000251 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 3 | 3 | B.1.222 | 0.005076 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 3 | 3 | B.1.258.17 | 0.000312 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 3 | 3 | B.1.568 | 0.003333 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | A | 0.000774 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 2 | AY.46.6 | 0.000072 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | AY.92 | 0.000575 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.1.207 | 0.002364 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.139 | 0.001466 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.177.77 | 0.001452 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | B.1.497 | 0.00063 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | C.32 | 0.046512 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | A.5 | 0.001923 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.120.2 | 0.001285 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.7.1 | 0.000113 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.219 | 0.005 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.309 | 0.005848 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.351 | 0.002793 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.1.507 | 0.008696 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.147 | 0.000756 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.160.29 | 0.004219 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.177.12 | 0.000152 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.177.16 | 0.000664 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.177.62 | 0.001192 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.346 | 0.001311 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.582 | 0.000491 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | B.28 | 0.003279 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | P.2 | 0.000187 |
| ORF1ab/nsp14A2-B | 504 | A504V | gCt | gTt | 1 | 1 | Q.1 | 0.000126 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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