CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 504 & Codon = Tct
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 504 | A504S | A6429S | nonsyn | Gct | Tct | 4930 | 4920 | 0.997972 | 19549-19551 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4920 | 4930 | All | 0.000941 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2837 | 2838 | AY.4 | 0.004416 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 294 | 294 | B.1.1.7 | 0.000263 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 264 | 264 | AY.26 | 0.007474 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 217 | 218 | B.1.617.2 | 0.000817 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 204 | 204 | AY.44 | 0.001242 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 180 | 180 | AY.43 | 0.000797 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 89 | 89 | B.1.36.38 | 0.146141 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 67 | 67 | B.1.36.2 | 0.72043 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 56 | 56 | AY.120 | 0.002082 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 45 | 47 | B.1.1 | 0.000816 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 42 | 42 | B.1.177 | 0.000553 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 39 | 39 | B.1.429 | 0.000918 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 38 | 38 | AY.102 | 0.001008 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 30 | 30 | AY.5 | 0.000619 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 30 | 30 | P.2 | 0.005599 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 29 | 29 | AY.60 | 0.027205 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 27 | 27 | AY.9.2 | 0.000992 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 21 | 21 | AY.47 | 0.000653 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 21 | 21 | B.1.311 | 0.005766 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 19 | 20 | B.1 | 0.000174 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 17 | 17 | AY.25 | 0.000102 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 17 | 17 | B.1.1.345 | 0.73913 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 17 | 17 | B.1.2 | 0.00015 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 14 | 14 | B.1.351 | 0.000416 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 14 | 14 | P.1 | 0.000221 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 13 | 13 | B.1.177.56 | 0.008678 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 13 | 13 | B.1.258 | 0.000865 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 11 | 11 | AY.3 | 0.000109 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 11 | 11 | AY.42 | 0.000443 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 10 | 10 | AY.117 | 0.000845 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 9 | 9 | AY.103 | 0.000056 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 8 | 8 | AY.29 | 0.000126 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 7 | 7 | AY.39 | 0.000173 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 7 | 7 | AY.4.5 | 0.000752 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 7 | 7 | B.1.1.318 | 0.002112 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 6 | 6 | AY.41 | 0.001764 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 6 | 6 | AY.46 | 0.000624 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 6 | 6 | AY.99 | 0.006296 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 5 | 5 | AY.20 | 0.000194 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 5 | 5 | B.1.565 | 0.004052 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 5 | 5 | N.4 | 0.021277 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | AY.23 | 0.000279 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 4 | AY.33 | 0.0002 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | AY.4.3 | 0.003367 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | B.1.1.519 | 0.000159 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | B.1.351.5 | 0.002398 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | B.1.525 | 0.000453 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 4 | 4 | C.37 | 0.000464 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.100 | 0.000138 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.104 | 0.005952 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.113 | 0.000427 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.27 | 0.000194 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.4.2 | 0.000065 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.4.2.1 | 0.000447 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.51 | 0.002727 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | AY.9 | 0.000203 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | B.1.1.10 | 0.003344 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | B.1.182 | 0.021739 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | P.1.14 | 0.000143 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | P.1.7 | 0.000958 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | Q.1 | 0.000379 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 3 | 3 | Q.4 | 0.001364 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 2 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | A.21 | 0.00554 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.108 | 0.002205 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 2 | AY.110 | 0.000113 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.119 | 0.000071 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.13 | 0.000322 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.16 | 0.000759 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.54 | 0.000191 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.73 | 0.001331 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.84 | 0.000875 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.85 | 0.000854 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | AY.98.1 | 0.000097 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.1.161 | 0.007067 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.1.216 | 0.001781 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.1.232 | 0.00363 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.1.70 | 0.000682 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.526 | 0.000047 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.596 | 0.000174 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.621 | 0.000177 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.627 | 0.00404 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.628 | 0.000705 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | B.1.637 | 0.000146 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 2 | 2 | Q.8 | 0.00033 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.1 | 0.000396 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.48 | 0.000465 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.81 | 0.001992 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.240 | 0.004695 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.317 | 0.000412 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.398 | 0.003226 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.47 | 0.005348 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.1.523 | 0.001563 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.177.23 | 0.003236 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.177.86 | 0.000183 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.210 | 0.002132 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.36.22 | 0.001208 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.404 | 0.001302 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.428 | 0.00102 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp14A2-B | 504 | A504S | Gct | Tct | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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