CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 384
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 384 | F384F | F6309F | syn | ttT | ttC | 119 | 119 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384del | F6309del | del | TTT | --- | 40 | 40 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384L | F6309L | nonsyn | Ttt | Ctt | 37 | 33 | 0.891892 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384L | F6309L | nonsyn | ttT | ttG | 37 | 4 | 0.108108 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384Y | F6309Y | nonsyn | tTt | tAt | 9 | 9 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384I | F6309I | nonsyn | Ttt | Att | 6 | 6 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | F6309del1 | del | Ttt | -tt | 6 | 5 | 0.833333 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | F6309del1 | del | ttT | tt- | 6 | 1 | 0.166667 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384S | F6309S | nonsyn | tTt | tCt | 4 | 4 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384V | F6309V | nonsyn | Ttt | Gtt | 3 | 3 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384X | F6309X | nonsyn | tTT | tAG | 2 | 2 | 1 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | F6309del2 | del | TTt | --t | 2 | 1 | 0.5 | 19189-19191 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | F6309del2 | del | tTT | t-- | 2 | 1 | 0.5 | 19189-19191 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 119 | 119 | All | 0.000023 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 50 | 50 | AY.18 | 0.505051 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 40 | 40 | All | 0.000008 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 33 | 37 | All | 0.000006 |
| ORF1ab/nsp14A2-B | 384 | F384L | ttT | ttG | 4 | 37 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 31 | 31 | B.1.1.7 | 0.000028 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 19 | 19 | B.1.1.7 | 0.000017 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 13 | 13 | AY.25 | 0.000078 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 9 | 11 | B.1.1.7 | 0.000008 |
| ORF1ab/nsp14A2-B | 384 | F384L | ttT | ttG | 2 | 11 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 9 | 9 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 9 | 9 | B.1.177 | 0.000119 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 7 | 7 | AY.4.2 | 0.000152 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 6 | 6 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | Ttt | -tt | 5 | 6 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | ttT | tt- | 1 | 6 | All | 0 |
| ORF1ab/nsp14A2-B | 384 | F384S | tTt | tCt | 4 | 4 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp14A2-B | 384 | F384V | Ttt | Gtt | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 3 | 3 | AY.44 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 3 | 3 | B.1.1.7 | 0.000003 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp14A2-B | 384 | F384L | ttT | ttG | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 384 | F384X | tTT | tAG | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 384 | F384X | tTT | tAG | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | TTt | --t | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | tTT | t-- | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 2 | 2 | AY.4.5 | 0.000215 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 2 | 2 | B.1.1.63 | 0.000772 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | Ttt | -tt | 2 | 2 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | Ttt | -tt | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 2 | 2 | B.1.2 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | A.27 | 0.001656 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | Ttt | -tt | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 384 | F384S | tTt | tCt | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 384 | F384del1 | ttT | tt- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | AY.72 | 0.001361 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 384 | F384S | tTt | tCt | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | TTt | --t | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384V | Ttt | Gtt | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B.1.1.311 | 0.000358 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.1.311 | 0.000358 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | B.1.1.348 | 0.000796 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp14A2-B | 384 | F384V | Ttt | Gtt | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384S | tTt | tCt | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384del2 | tTT | t-- | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | B.1.149 | 0.003425 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | B.1.160.8 | 0.001289 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.177.15 | 0.000631 |
| ORF1ab/nsp14A2-B | 384 | F384V | Ttt | Gtt | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.177.51 | 0.004566 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.177.69 | 0.001484 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B.1.189 | 0.004292 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | B.1.222 | 0.001692 |
| ORF1ab/nsp14A2-B | 384 | F384del | TTT | --- | 1 | 1 | B.1.258.3 | 0.001675 |
| ORF1ab/nsp14A2-B | 384 | F384L | Ttt | Ctt | 1 | 1 | B.1.36.38 | 0.001642 |
| ORF1ab/nsp14A2-B | 384 | F384S | tTt | tCt | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 384 | F384Y | tTt | tAt | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 384 | F384F | ttT | ttC | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 384 | F384I | Ttt | Att | 1 | 1 | B.1.628 | 0.000352 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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