CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 368
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 368 | Y368Y | Y6293Y | syn | taT | taC | 345 | 345 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368del | Y6293del | del | TAT | --- | 18 | 18 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368F | Y6293F | nonsyn | tAt | tTt | 14 | 14 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Y6293H | nonsyn | Tat | Cat | 14 | 14 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Y6293del1 | del | Tat | -at | 4 | 3 | 0.75 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368X | Y6293X | nonsyn | taT | taA | 4 | 2 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368X | Y6293X | nonsyn | taT | taG | 4 | 2 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Y6293del1 | del | taT | ta- | 4 | 1 | 0.25 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368N | Y6293N | nonsyn | Tat | Aat | 2 | 2 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368L | Y6293L | nonsyn | TAt | CTt | 2 | 1 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368I | Y6293I | nonsyn | TAT | ATA | 2 | 1 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368I | Y6293I | nonsyn | TAt | ATt | 2 | 1 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368L | Y6293L | nonsyn | tAT | tTA | 2 | 1 | 0.5 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368K | Y6293K | nonsyn | TaT | AaA | 1 | 1 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368S | Y6293S | nonsyn | tAT | tCG | 1 | 1 | 1 | 19141-19143 |
| ORF1ab/nsp14A2-B | 368 | Y368A | Y6293A | nonsyn | TAT | GCC | 1 | 1 | 1 | 19141-19143 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 345 | 345 | All | 0.000066 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 128 | 128 | B.1.415.1 | 0.969697 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 65 | 65 | B.1.415 | 0.928571 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 24 | 24 | P.1 | 0.000378 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 23 | 23 | AY.118 | 0.001441 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 18 | 18 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 18 | 18 | B.1.1.7 | 0.000016 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 14 | 14 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 14 | 14 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 10 | 10 | B.1.1.7 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 8 | 8 | AY.4 | 0.000012 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 8 | 8 | AY.43 | 0.000035 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 8 | 8 | B.1.258 | 0.000532 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 6 | 6 | AY.44 | 0.000037 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 6 | 6 | B.1.351.5 | 0.003597 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 5 | 5 | AY.5 | 0.000103 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 5 | 5 | B.1.623 | 0.002682 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Tat | -at | 3 | 4 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taA | 2 | 4 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taG | 2 | 4 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | taT | ta- | 1 | 4 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 4 | 4 | P.1.10 | 0.001078 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 3 | 3 | AY.102 | 0.00008 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 3 | 3 | AY.3.1 | 0.000256 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 3 | 3 | B.1 | 0.000027 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 3 | 3 | B.1.1.25 | 0.001706 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 3 | 3 | B.1.617.2 | 0.000011 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 368 | Y368L | TAt | CTt | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368L | tAT | tTA | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368I | TAt | ATt | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368I | TAT | ATA | 1 | 2 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368N | Tat | Aat | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368L | tAT | tTA | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368I | TAt | ATt | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368I | TAT | ATA | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368L | TAt | CTt | 1 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | AY.103 | 0.000012 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | AY.25 | 0.000012 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 2 | 2 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | B.1.433 | 0.00639 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | P.1.12 | 0.000968 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368K | TaT | AaA | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taA | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368N | Tat | Aat | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 368 | Y368A | TAT | GCC | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368K | TaT | AaA | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368S | tAT | tCG | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taG | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 368 | Y368N | Tat | Aat | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 368 | Y368A | TAT | GCC | 1 | 1 | AY.48 | 0.000465 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | taT | ta- | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.1.311 | 0.000358 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Tat | -at | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.177.21 | 0.000076 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.177.82 | 0.000477 |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taA | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Tat | -at | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 368 | Y368del1 | Tat | -at | 1 | 1 | B.1.206 | 0.000816 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | B.1.258.21 | 0.007752 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.415 | 0.014286 |
| ORF1ab/nsp14A2-B | 368 | Y368H | Tat | Cat | 1 | 1 | B.1.438.1 | 0.000107 |
| ORF1ab/nsp14A2-B | 368 | Y368X | taT | taG | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 368 | Y368del | TAT | --- | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 368 | Y368S | tAT | tCG | 1 | 1 | B.53 | 0.011765 |
| ORF1ab/nsp14A2-B | 368 | Y368F | tAt | tTt | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 368 | Y368Y | taT | taC | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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