CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 338
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 338 | I338I | I6263I | syn | atT | atC | 624 | 613 | 0.982372 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338I | I6263I | syn | atT | atA | 624 | 11 | 0.0176282 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338V | I6263V | nonsyn | Att | Gtt | 174 | 174 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338L | I6263L | nonsyn | Att | Ctt | 130 | 130 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338T | I6263T | nonsyn | aTt | aCt | 84 | 83 | 0.988095 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338T | I6263T | nonsyn | aTT | aCC | 84 | 1 | 0.0119048 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338del | I6263del | del | ATT | --- | 19 | 19 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338M | I6263M | nonsyn | atT | atG | 4 | 4 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338N | I6263N | nonsyn | aTt | aAt | 1 | 1 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338del1 | I6263del1 | del | Att | -tt | 1 | 1 | 1 | 19051-19053 |
| ORF1ab/nsp14A2-B | 338 | I338P | I6263P | nonsyn | ATt | CCt | 1 | 1 | 1 | 19051-19053 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 613 | 624 | All | 0.000117 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 11 | 624 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 206 | 206 | AY.4 | 0.000321 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 174 | 174 | All | 0.000033 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 149 | 149 | C.1.2 | 0.634043 |
| ORF1ab/nsp14A2-B | 338 | I338L | Att | Ctt | 130 | 130 | All | 0.000025 |
| ORF1ab/nsp14A2-B | 338 | I338L | Att | Ctt | 119 | 119 | B.1.1.7 | 0.000107 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 106 | 106 | AY.4.2 | 0.002299 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 83 | 84 | All | 0.000016 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTT | aCC | 1 | 84 | All | 0 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 73 | 73 | AY.4 | 0.000114 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 47 | 47 | AY.3 | 0.000467 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 30 | 30 | B.1.36.8 | 0.03 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 23 | 23 | C.36.3.1 | 0.0625 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 19 | 19 | All | 0.000004 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 19 | 19 | B.1.214.2 | 0.011391 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 18 | 18 | B.1.36.29 | 0.009312 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 17 | 17 | AY.25 | 0.000102 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 16 | 16 | B.1.526 | 0.000376 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 13 | 14 | B.1.1.7 | 0.000012 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 1 | 14 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 14 | 14 | B.1.526 | 0.000329 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 13 | 13 | B.1.1.7 | 0.000012 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 12 | 12 | B.1.1.7 | 0.000011 |
| ORF1ab/nsp14A2-B | 338 | I338L | Att | Ctt | 9 | 9 | B.1.409 | 0.007031 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 8 | 8 | B.1.617.2 | 0.00003 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 7 | 7 | AY.9 | 0.000473 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 6 | 6 | AY.43 | 0.000027 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 6 | 6 | B.1.617.2 | 0.000023 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 5 | 5 | B.1.1 | 0.000091 |
| ORF1ab/nsp14A2-B | 338 | I338M | atT | atG | 4 | 4 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 4 | 4 | B.1.617.2 | 0.000015 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 4 | 4 | P.1 | 0.000063 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 3 | 3 | AY.102 | 0.00008 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | AY.103 | 0.000019 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | AY.20 | 0.000117 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | AY.39.1 | 0.000119 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 3 | 3 | AY.4 | 0.000005 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 2 | 3 | AY.43 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 3 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp14A2-B | 338 | I338M | atT | atG | 3 | 3 | B.1.1.222 | 0.000612 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | B.1.462 | 0.021739 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 3 | 3 | B.1.525 | 0.000339 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | AY.106 | 0.00067 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | AY.47 | 0.000062 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 2 | 2 | B.1.234 | 0.000264 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | B.1.267 | 0.037037 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 2 | 2 | B.1.429 | 0.000047 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 2 | 2 | C.37 | 0.000232 |
| ORF1ab/nsp14A2-B | 338 | I338N | aTt | aAt | 1 | 1 | 0.055556 | |
| ORF1ab/nsp14A2-B | 338 | I338N | aTt | aAt | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 338 | I338del1 | Att | -tt | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 338 | I338P | ATt | CCt | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 338 | I338L | Att | Ctt | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | AY.86 | 0.00083 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338M | atT | atG | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.1.107 | 0.032258 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 338 | I338P | ATt | CCt | 1 | 1 | B.1.36.1 | 0.00114 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | B.1.415 | 0.014286 |
| ORF1ab/nsp14A2-B | 338 | I338del1 | Att | -tt | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTT | aCC | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | B.1.564.1 | 0.001577 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp14A2-B | 338 | I338V | Att | Gtt | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atC | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 338 | I338I | atT | atA | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 338 | I338del | ATT | --- | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 338 | I338T | aTt | aCt | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp14A2-B | 338 | I338L | Att | Ctt | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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