CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 334
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 334 | N334N | N6259N | syn | aaC | aaT | 651 | 651 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334del | N6259del | del | AAC | --- | 18 | 18 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334S | N6259S | nonsyn | aAc | aGc | 15 | 15 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334K | N6259K | nonsyn | aaC | aaA | 11 | 8 | 0.727273 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334K | N6259K | nonsyn | aaC | aaG | 11 | 3 | 0.272727 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | N6259del1 | del | aaC | aa- | 6 | 3 | 0.5 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | N6259del1 | del | Aac | -ac | 6 | 3 | 0.5 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334D | N6259D | nonsyn | Aac | Gac | 4 | 4 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | N6259del2 | del | aAC | a-- | 3 | 2 | 0.666667 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | N6259del2 | del | AAC | --T | 3 | 1 | 0.333333 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334T | N6259T | nonsyn | aAc | aCc | 2 | 2 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334H | N6259H | nonsyn | Aac | Cac | 1 | 1 | 1 | 19039-19041 |
| ORF1ab/nsp14A2-B | 334 | N334I | N6259I | nonsyn | aAc | aTc | 1 | 1 | 1 | 19039-19041 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 651 | 651 | All | 0.000125 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 72 | 72 | B.1.1.7 | 0.000064 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 70 | 70 | AY.44 | 0.000426 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 69 | 69 | AY.39 | 0.001705 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 65 | 65 | AY.4 | 0.000101 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 40 | 40 | B.1.617.2 | 0.000151 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 35 | 35 | AY.107 | 0.016309 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 32 | 32 | AY.29.1 | 0.007056 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 30 | 30 | N.10 | 0.882353 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 28 | 28 | AY.103 | 0.000174 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 28 | 28 | P.1 | 0.000441 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 18 | 18 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 16 | 16 | AY.43 | 0.000071 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 15 | 15 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 15 | 15 | B.1.1 | 0.000272 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 8 | 11 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaG | 3 | 11 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 11 | 11 | B.1.1.7 | 0.00001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 7 | 7 | B.1.1.33 | 0.002946 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 7 | 7 | B.1.1.519 | 0.000278 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 7 | 7 | B.1.2 | 0.000062 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | aaC | aa- | 3 | 6 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | Aac | -ac | 3 | 6 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 5 | 5 | AY.102 | 0.000133 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 5 | 5 | AY.118 | 0.000313 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 5 | 5 | AY.20 | 0.000194 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 5 | 5 | AY.29 | 0.000079 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 5 | 5 | AY.4.2 | 0.000108 |
| ORF1ab/nsp14A2-B | 334 | N334D | Aac | Gac | 4 | 4 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 4 | 4 | AY.100 | 0.000184 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 4 | 4 | B.1 | 0.000037 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 4 | 4 | B.1.429 | 0.000094 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | A.27 | 0.004967 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | aAC | a-- | 2 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | AAC | --T | 1 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | AY.117 | 0.000254 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | AY.119 | 0.000106 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | AY.13 | 0.000483 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | AY.5 | 0.000062 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaG | 2 | 3 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 3 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp14A2-B | 334 | N334T | aAc | aCc | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.23 | 0.000139 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 2 | 2 | AY.25 | 0.000012 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.25 | 0.000012 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 2 | 2 | AY.4 | 0.000003 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.72 | 0.002721 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.9.2 | 0.000073 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | B.1.1.231 | 0.006192 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 2 | 2 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | aAC | a-- | 2 | 2 | B.1.1.7 | 0.000002 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | B.1.1.70 | 0.000682 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | B.1.177.62 | 0.002384 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | B.1.470 | 0.002809 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 2 | 2 | B.1.617.2 | 0.000008 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 2 | 2 | B.40 | 0.000729 |
| ORF1ab/nsp14A2-B | 334 | N334T | aAc | aCc | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 334 | N334H | Aac | Cac | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 334 | N334I | aAc | aTc | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.101 | 0.00049 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.120 | 0.000037 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | aaC | aa- | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaG | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.34.1 | 0.00051 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.38 | 0.000499 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 334 | N334D | Aac | Gac | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | aaC | aa- | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.64 | 0.000595 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.77 | 0.001127 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.82 | 0.001357 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.94 | 0.000443 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.95 | 0.000761 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | aaC | aa- | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 334 | N334D | Aac | Gac | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 1 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.1.432 | 0.001266 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | Aac | -ac | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.139 | 0.000733 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.170 | 0.00431 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 1 | B.1.177.23 | 0.003236 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp14A2-B | 334 | N334H | Aac | Cac | 1 | 1 | B.1.177.51 | 0.004566 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.177.56 | 0.000668 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp14A2-B | 334 | N334T | aAc | aCc | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | Aac | -ac | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 334 | N334K | aaC | aaA | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.239 | 0.001221 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.355 | 0.011111 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.399 | 0.001934 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | B.1.415 | 0.014286 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.426 | 0.001009 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.453 | 0.003236 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp14A2-B | 334 | N334S | aAc | aGc | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp14A2-B | 334 | N334del1 | Aac | -ac | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp14A2-B | 334 | N334D | Aac | Gac | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp14A2-B | 334 | N334D | Aac | Gac | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp14A2-B | 334 | N334del2 | AAC | --T | 1 | 1 | C.17 | 0.055556 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp14A2-B | 334 | N334I | aAc | aTc | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 334 | N334del | AAC | --- | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | Q.8 | 0.000165 |
| ORF1ab/nsp14A2-B | 334 | N334N | aaC | aaT | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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