CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp14A2-B : CodonNum = 246
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp14A2-B | 246 | Q246Q | Q6171Q | syn | caA | caG | 371 | 371 | 1 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246del | Q6171del | del | CAA | --- | 67 | 67 | 1 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246H | Q6171H | nonsyn | caA | caC | 26 | 15 | 0.576923 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246H | Q6171H | nonsyn | caA | caT | 26 | 11 | 0.423077 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Q6171K | nonsyn | Caa | Aaa | 13 | 12 | 0.923077 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Q6171K | nonsyn | CaA | AaG | 13 | 1 | 0.0769231 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246P | Q6171P | nonsyn | cAa | cCa | 9 | 5 | 0.555556 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246P | Q6171P | nonsyn | cAA | cCC | 9 | 2 | 0.222222 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246P | Q6171P | nonsyn | cAA | cCT | 9 | 2 | 0.222222 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Q6171X | nonsyn | Caa | Taa | 5 | 5 | 1 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | Q6171del1 | del | caA | ca- | 5 | 3 | 0.6 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | Q6171del1 | del | cAa | c-a | 5 | 1 | 0.2 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | Q6171del1 | del | CAA | -NN | 5 | 1 | 0.2 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246R | Q6171R | nonsyn | cAa | cGa | 3 | 3 | 1 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246T | Q6171T | nonsyn | CAA | ACT | 3 | 2 | 0.666667 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246L | Q6171L | nonsyn | cAa | cTa | 3 | 2 | 0.666667 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246L | Q6171L | nonsyn | CAa | TTa | 3 | 1 | 0.333333 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246T | Q6171T | nonsyn | CAA | ACC | 3 | 1 | 0.333333 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246N | Q6171N | nonsyn | CaA | AaT | 2 | 2 | 1 | 18775-18777 |
| ORF1ab/nsp14A2-B | 246 | Q246del2 | Q6171del2 | del | cAA | c-- | 1 | 1 | 1 | 18775-18777 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 371 | 371 | All | 0.000071 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 67 | 67 | All | 0.000013 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 52 | 52 | P.2 | 0.009705 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 46 | 46 | AY.4 | 0.000072 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 42 | 42 | B.1.1.7 | 0.000038 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 38 | 38 | B.1.617.2 | 0.000143 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 31 | 31 | AY.120 | 0.001153 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 28 | 28 | B.1.427 | 0.001414 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 27 | 27 | B.1.1.7 | 0.000024 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 15 | 26 | All | 0.000003 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 11 | 26 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 25 | 25 | N.2 | 0.961538 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 12 | 13 | All | 0.000002 |
| ORF1ab/nsp14A2-B | 246 | Q246K | CaA | AaG | 1 | 13 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 12 | 12 | AY.25 | 0.000072 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 5 | 9 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAA | cCT | 2 | 9 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAA | cCC | 2 | 9 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 9 | 9 | AY.43 | 0.00004 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 9 | 9 | AY.44 | 0.000055 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 9 | 9 | B.1.526 | 0.000212 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 8 | 8 | B.1.400 | 0.003432 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 5 | 5 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | caA | ca- | 3 | 5 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | CAA | -NN | 1 | 5 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | cAa | c-a | 1 | 5 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 3 | 5 | AY.4 | 0.000005 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 2 | 5 | AY.4 | 0.000003 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 5 | 5 | AY.43 | 0.000022 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 4 | 4 | 0.222222 | |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 2 | 4 | 0.111111 | |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 2 | 4 | 0.111111 | |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 4 | 4 | AY.12 | 0.001264 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 4 | 4 | B.1.1.416 | 0.00362 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 4 | 4 | B.1.2 | 0.000035 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 4 | 4 | B.1.234 | 0.000528 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 4 | 4 | B.1.617.2 | 0.000015 |
| ORF1ab/nsp14A2-B | 246 | Q246R | cAa | cGa | 3 | 3 | All | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246L | cAa | cTa | 2 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246T | CAA | ACT | 2 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246L | CAa | TTa | 1 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246T | CAA | ACC | 1 | 3 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 3 | 3 | AY.4 | 0.000005 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 3 | 3 | B.1.1 | 0.000054 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 3 | 3 | B.1.1.33 | 0.001263 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 3 | 3 | B.1.1.7 | 0.000003 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 3 | 3 | B.1.1.7 | 0.000003 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 3 | 3 | P.1 | 0.000047 |
| ORF1ab/nsp14A2-B | 246 | Q246N | CaA | AaT | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAA | cCT | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 246 | Q246T | CAA | ACT | 2 | 2 | 0.111111 | |
| ORF1ab/nsp14A2-B | 246 | Q246N | CaA | AaT | 2 | 2 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | AY.2 | 0.000712 |
| ORF1ab/nsp14A2-B | 246 | Q246R | cAa | cGa | 2 | 2 | AY.3 | 0.00002 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 2 | 2 | AY.43 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | AY.46.6 | 0.000144 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 2 | 2 | AY.6 | 0.000082 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | B.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 2 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246K | CaA | AaG | 1 | 2 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAA | cCC | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 1 | 2 | B.1.1 | 0.000018 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | B.1.1.214 | 0.000111 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 2 | 2 | C.37 | 0.000232 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 2 | 2 | D.2 | 0.00015 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp14A2-B | 246 | Q246del2 | cAA | c-- | 1 | 1 | All | 0 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.102 | 0.000027 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.108 | 0.001103 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.120.2 | 0.001285 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | AY.3 | 0.00001 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp14A2-B | 246 | Q246del2 | cAA | c-- | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 246 | Q246L | cAa | cTa | 1 | 1 | AY.4 | 0.000002 |
| ORF1ab/nsp14A2-B | 246 | Q246L | cAa | cTa | 1 | 1 | AY.4.3 | 0.000842 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | caA | ca- | 1 | 1 | AY.43 | 0.000004 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.72 | 0.001361 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | AY.81 | 0.001992 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | caA | ca- | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp14A2-B | 246 | Q246R | cAa | cGa | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 1 | 1 | B.1 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.1.139 | 0.022727 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.1.311 | 0.000358 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.1.328 | 0.016949 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.1.413 | 0.006897 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.1.487 | 0.005587 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246T | CAA | ACC | 1 | 1 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.1.70 | 0.000341 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.161 | 0.017241 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.177 | 0.000013 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.177.11 | 0.001698 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | caA | ca- | 1 | 1 | B.1.177.17 | 0.000821 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.177.54 | 0.000606 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.177.63 | 0.002703 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.177.69 | 0.001484 |
| ORF1ab/nsp14A2-B | 246 | Q246X | Caa | Taa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAa | cCa | 1 | 1 | B.1.2 | 0.000009 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.218 | 0.005155 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.221 | 0.000071 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | CAA | -NN | 1 | 1 | B.1.242 | 0.018868 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.258.16 | 0.001637 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caT | 1 | 1 | B.1.425 | 0.002994 |
| ORF1ab/nsp14A2-B | 246 | Q246K | Caa | Aaa | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.530 | 0.007143 |
| ORF1ab/nsp14A2-B | 246 | Q246Q | caA | caG | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp14A2-B | 246 | Q246P | cAA | cCC | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 246 | Q246del1 | cAa | c-a | 1 | 1 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | B.1.630 | 0.005236 |
| ORF1ab/nsp14A2-B | 246 | Q246L | CAa | TTa | 1 | 1 | C.17 | 0.055556 |
| ORF1ab/nsp14A2-B | 246 | Q246H | caA | caC | 1 | 1 | P.1 | 0.000016 |
| ORF1ab/nsp14A2-B | 246 | Q246del | CAA | --- | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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