CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = Y277C

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13277Y277CY5601CnonsyntAttGt5675660.99823617065-17067
ORF1ab/nsp13277Y277CY5601CnonsyntATtGC56710.0017636717065-17067

Details of the mutation Y277C within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13277Y277CtAttGt566567All0.000108
ORF1ab/nsp13277Y277CtATtGC1567All0
ORF1ab/nsp13277Y277CtAttGt215215B.1.6180.866935
ORF1ab/nsp13277Y277CtAttGt141141B.1.1.70.000126
ORF1ab/nsp13277Y277CtAttGt3333AY.40.000051
ORF1ab/nsp13277Y277CtAttGt3131B.1.4800.077114
ORF1ab/nsp13277Y277CtAttGt1717B.1.617.20.000064
ORF1ab/nsp13277Y277CtAttGt1515B.1.5820.00736
ORF1ab/nsp13277Y277CtAttGt1111B.1.1770.000145
ORF1ab/nsp13277Y277CtAttGt1111B.1.20.000097
ORF1ab/nsp13277Y277CtAttGt1010B.1.2580.000665
ORF1ab/nsp13277Y277CtAttGt99AY.610.000943
ORF1ab/nsp13277Y277CtAttGt66B.10.000055
ORF1ab/nsp13277Y277CtAttGt66B.1.80.011834
ORF1ab/nsp13277Y277CtAttGt55AY.260.000142
ORF1ab/nsp13277Y277CtAttGt44AY.250.000024
ORF1ab/nsp13277Y277CtAttGt33B.1.1.3170.001235
ORF1ab/nsp13277Y277CtAttGt33B.1.3510.000089
ORF1ab/nsp13277Y277CtATtGC120.055556
ORF1ab/nsp13277Y277CtAttGt120.055556
ORF1ab/nsp13277Y277CtAttGt22AY.1210.000271
ORF1ab/nsp13277Y277CtAttGt22B.1.1.280.000622
ORF1ab/nsp13277Y277CtAttGt22B.1.1.2840.000215
ORF1ab/nsp13277Y277CtAttGt22B.1.177.80.001505
ORF1ab/nsp13277Y277CtAttGt22B.1.4000.000858
ORF1ab/nsp13277Y277CtAttGt22B.1.617.10.000258
ORF1ab/nsp13277Y277CtAttGt11A0.000387
ORF1ab/nsp13277Y277CtAttGt11AY.100.00053
ORF1ab/nsp13277Y277CtAttGt11AY.290.000016
ORF1ab/nsp13277Y277CtAttGt11AY.30.00001
ORF1ab/nsp13277Y277CtAttGt11AY.300.000396
ORF1ab/nsp13277Y277CtAttGt11AY.440.000006
ORF1ab/nsp13277Y277CtAttGt11AY.450.000122
ORF1ab/nsp13277Y277CtAttGt11AY.710.000475
ORF1ab/nsp13277Y277CtAttGt11AY.970.001701
ORF1ab/nsp13277Y277CtAttGt11AZ.50.003509
ORF1ab/nsp13277Y277CtAttGt11B.1.1.2540.011236
ORF1ab/nsp13277Y277CtAttGt11B.1.1.2940.001266
ORF1ab/nsp13277Y277CtAttGt11B.1.1.3260.001761
ORF1ab/nsp13277Y277CtAttGt11B.1.1.910.166667
ORF1ab/nsp13277Y277CtAttGt11B.1.110.30.000718
ORF1ab/nsp13277Y277CtAttGt11B.1.1600.000031
ORF1ab/nsp13277Y277CtAttGt11B.1.177.450.000381
ORF1ab/nsp13277Y277CtAttGt11B.1.2210.000071
ORF1ab/nsp13277Y277CtAttGt11B.1.2320.000537
ORF1ab/nsp13277Y277CtAttGt11B.1.2430.00007
ORF1ab/nsp13277Y277CtAttGt11B.1.3110.000275
ORF1ab/nsp13277Y277CtAttGt11B.1.36.170.000494
ORF1ab/nsp13277Y277CtAttGt11B.1.3910.001127
ORF1ab/nsp13277Y277CtAttGt11B.1.4290.000024
ORF1ab/nsp13277Y277CtAttGt11B.1.595.10.005848
ORF1ab/nsp13277Y277CtAttGt11B.1.5960.000087
ORF1ab/nsp13277Y277CtAttGt11B.1.6370.000073
ORF1ab/nsp13277Y277CtAttGt11B.230.002924
ORF1ab/nsp13277Y277CtAttGt11B.400.000364
ORF1ab/nsp13277Y277CtAttGt11D.20.000075
ORF1ab/nsp13277Y277CtAttGt11P.10.000016
ORF1ab/nsp13277Y277CtAttGt11P.1.120.000484
ORF1ab/nsp13277Y277CtAttGt11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.