CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = V193L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13193V193LV5517LnonsynGtaTta105210440.99239516813-16815
ORF1ab/nsp13193V193LV5517LnonsynGtaCta105270.0066539916813-16815
ORF1ab/nsp13193V193LV5517LnonsynGtACtT105210.0009505716813-16815

Details of the mutation V193L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13193V193LGtaTta10441052All0.0002
ORF1ab/nsp13193V193LGtaCta71052All0.000001
ORF1ab/nsp13193V193LGtACtT11052All0
ORF1ab/nsp13193V193LGtaTta412415B.1.1.70.000369
ORF1ab/nsp13193V193LGtaCta3415B.1.1.70.000003
ORF1ab/nsp13193V193LGtaTta132133B.10.001209
ORF1ab/nsp13193V193LGtaCta1133B.10.000009
ORF1ab/nsp13193V193LGtaTta5656B.1.1600.001747
ORF1ab/nsp13193V193LGtaTta4444B.1.2580.002928
ORF1ab/nsp13193V193LGtaTta3333AY.40.000051
ORF1ab/nsp13193V193LGtaTta2929B.1.617.20.000109
ORF1ab/nsp13193V193LGtaTta2525AY.430.000111
ORF1ab/nsp13193V193LGtaTta2525B.1.2340.003299
ORF1ab/nsp13193V193LGtaTta2323AY.1170.001944
ORF1ab/nsp13193V193LGtaTta1718B.1.20.00015
ORF1ab/nsp13193V193LGtaCta118B.1.20.000009
ORF1ab/nsp13193V193LGtaTta1515AY.250.00009
ORF1ab/nsp13193V193LGtaTta1414B.1.177.460.012856
ORF1ab/nsp13193V193LGtaTta1111AY.440.000067
ORF1ab/nsp13193V193LGtaTta99AY.1000.000414
ORF1ab/nsp13193V193LGtaTta99B.1.1770.000119
ORF1ab/nsp13193V193LGtaTta99Q.30.001305
ORF1ab/nsp13193V193LGtaTta99Q.80.001484
ORF1ab/nsp13193V193LGtaTta88AY.1020.000212
ORF1ab/nsp13193V193LGtaTta68B.1.10.000109
ORF1ab/nsp13193V193LGtACtT18B.1.10.000018
ORF1ab/nsp13193V193LGtaCta18B.1.10.000018
ORF1ab/nsp13193V193LGtaTta88B.1.5750.002427
ORF1ab/nsp13193V193LGtaTta66AY.1030.000037
ORF1ab/nsp13193V193LGtaTta66AY.390.000148
ORF1ab/nsp13193V193LGtaTta66B.1.4290.000141
ORF1ab/nsp13193V193LGtaTta44AY.200.000155
ORF1ab/nsp13193V193LGtaTta44AY.4.20.000087
ORF1ab/nsp13193V193LGtaTta44AY.450.000487
ORF1ab/nsp13193V193LGtaTta44AY.980.000316
ORF1ab/nsp13193V193LGtaTta44B.1.1.2420.173913
ORF1ab/nsp13193V193LGtaTta44B.1.2430.000278
ORF1ab/nsp13193V193LGtaTta44P.10.000063
ORF1ab/nsp13193V193LGtaTta33A.10.000846
ORF1ab/nsp13193V193LGtaTta33AY.260.000085
ORF1ab/nsp13193V193LGtaTta33AY.290.000047
ORF1ab/nsp13193V193LGtaTta33AY.340.000291
ORF1ab/nsp13193V193LGtaTta33AY.39.10.000119
ORF1ab/nsp13193V193LGtaTta33AY.420.000121
ORF1ab/nsp13193V193LGtaTta33AY.46.20.001906
ORF1ab/nsp13193V193LGtaTta33AY.530.000863
ORF1ab/nsp13193V193LGtaTta33B.1.1.5190.000119
ORF1ab/nsp13193V193LGtaTta33B.1.3510.000089
ORF1ab/nsp13193V193LGtaTta33B.1.4250.008982
ORF1ab/nsp13193V193LGtaTta22AY.1200.000074
ORF1ab/nsp13193V193LGtaTta22AY.280.003781
ORF1ab/nsp13193V193LGtaTta22AY.30.00002
ORF1ab/nsp13193V193LGtaTta22AY.46.60.000144
ORF1ab/nsp13193V193LGtaTta22AY.470.000062
ORF1ab/nsp13193V193LGtaTta22AY.50.000041
ORF1ab/nsp13193V193LGtaTta22AY.710.00095
ORF1ab/nsp13193V193LGtaTta22AY.98.10.000097
ORF1ab/nsp13193V193LGtaTta22B.1.1.2840.000215
ORF1ab/nsp13193V193LGtaTta22B.1.1.4320.002532
ORF1ab/nsp13193V193LGtaTta22B.1.177.120.000303
ORF1ab/nsp13193V193LGtaCta12B.1.5960.000087
ORF1ab/nsp13193V193LGtaTta12B.1.5960.000087
ORF1ab/nsp13193V193LGtaTta22B.1.617.10.000258
ORF1ab/nsp13193V193LGtaTta22P.1.140.000096
ORF1ab/nsp13193V193LGtaTta22P.1.170.000324
ORF1ab/nsp13193V193LGtaTta22Q.20.001227
ORF1ab/nsp13193V193LGtaTta11A.210.00277
ORF1ab/nsp13193V193LGtaTta11AG.10.066667
ORF1ab/nsp13193V193LGtaTta11AY.1060.000335
ORF1ab/nsp13193V193LGtaTta11AY.1190.000035
ORF1ab/nsp13193V193LGtaTta11AY.230.00007
ORF1ab/nsp13193V193LGtaTta11AY.270.000065
ORF1ab/nsp13193V193LGtaTta11AY.330.000067
ORF1ab/nsp13193V193LGtaTta11AY.380.000499
ORF1ab/nsp13193V193LGtaTta11AY.460.000104
ORF1ab/nsp13193V193LGtaTta11AY.5.30.000337
ORF1ab/nsp13193V193LGtaTta11AY.520.000814
ORF1ab/nsp13193V193LGtaTta11AY.610.000105
ORF1ab/nsp13193V193LGtaTta11AY.670.000464
ORF1ab/nsp13193V193LGtaTta11AY.690.000187
ORF1ab/nsp13193V193LGtaTta11AY.9.20.000037
ORF1ab/nsp13193V193LGtaTta11AY.970.001701
ORF1ab/nsp13193V193LGtaTta11AY.99.20.000092
ORF1ab/nsp13193V193LGtaTta11B0.000128
ORF1ab/nsp13193V193LGtaTta11B.1.1.2200.001859
ORF1ab/nsp13193V193LGtaTta11B.1.1.2220.000204
ORF1ab/nsp13193V193LGtaTta11B.1.1.270.00565
ORF1ab/nsp13193V193LGtaTta11B.1.1.3160.000925
ORF1ab/nsp13193V193LGtaTta11B.1.1.4090.002833
ORF1ab/nsp13193V193LGtaTta11B.1.1.4160.000905
ORF1ab/nsp13193V193LGtaTta11B.1.160.260.002421
ORF1ab/nsp13193V193LGtaTta11B.1.1700.00431
ORF1ab/nsp13193V193LGtaTta11B.1.177.440.000519
ORF1ab/nsp13193V193LGtaTta11B.1.2400.000216
ORF1ab/nsp13193V193LGtaTta11B.1.3110.000275
ORF1ab/nsp13193V193LGtaTta11B.1.3690.000285
ORF1ab/nsp13193V193LGtaTta11B.1.4260.001009
ORF1ab/nsp13193V193LGtaTta11B.1.4270.00005
ORF1ab/nsp13193V193LGtaTta11B.1.4590.004082
ORF1ab/nsp13193V193LGtaTta11B.1.4660.023256
ORF1ab/nsp13193V193LGtaTta11B.1.4700.001404
ORF1ab/nsp13193V193LGtaTta11B.1.5240.001406
ORF1ab/nsp13193V193LGtaTta11B.1.5260.000024
ORF1ab/nsp13193V193LGtaTta11C.370.000116
ORF1ab/nsp13193V193LGtaTta11D.20.000075
ORF1ab/nsp13193V193LGtaTta11Q.10.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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