CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = S74P

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp1374S74PS5398PnonsynTcaCca24632463116456-16458

Details of the mutation S74P within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp1374S74PTcaCca24632463All0.000471
ORF1ab/nsp1374S74PTcaCca910910B.1.1.1530.996714
ORF1ab/nsp1374S74PTcaCca648648B.1.1.70.00058
ORF1ab/nsp1374S74PTcaCca150150B.1.20.001321
ORF1ab/nsp1374S74PTcaCca149149B.10.001365
ORF1ab/nsp1374S74PTcaCca9696B.1.1.3170.039522
ORF1ab/nsp1374S74PTcaCca9595B.1.1.3710.989583
ORF1ab/nsp1374S74PTcaCca2323P.1.70.007344
ORF1ab/nsp1374S74PTcaCca2121B.1.1.4160.019005
ORF1ab/nsp1374S74PTcaCca1919B.1.5670.063333
ORF1ab/nsp1374S74PTcaCca1717AY.440.000103
ORF1ab/nsp1374S74PTcaCca1717B.1.4290.0004
ORF1ab/nsp1374S74PTcaCca1414AY.40.000022
ORF1ab/nsp1374S74PTcaCca1414P.10.000221
ORF1ab/nsp1374S74PTcaCca1212B.1.617.20.000045
ORF1ab/nsp1374S74PTcaCca1212B.1.6190.010453
ORF1ab/nsp1374S74PTcaCca1111AY.620.004793
ORF1ab/nsp1374S74PTcaCca1111B.1.10.0002
ORF1ab/nsp1374S74PTcaCca1111B.1.5400.106796
ORF1ab/nsp1374S74PTcaCca1111C.370.001277
ORF1ab/nsp1374S74PTcaCca1010B.1.1.2770.007587
ORF1ab/nsp1374S74PTcaCca1010B.1.2210.00071
ORF1ab/nsp1374S74PTcaCca99B.1.3360.021951
ORF1ab/nsp1374S74PTcaCca99B.1.3510.000268
ORF1ab/nsp1374S74PTcaCca99Q.80.001484
ORF1ab/nsp1374S74PTcaCca88Q.10.001011
ORF1ab/nsp1374S74PTcaCca77AY.260.000198
ORF1ab/nsp1374S74PTcaCca66AY.1030.000037
ORF1ab/nsp1374S74PTcaCca66AY.250.000036
ORF1ab/nsp1374S74PTcaCca66B.1.1.5190.000238
ORF1ab/nsp1374S74PTcaCca55B.1.6230.002682
ORF1ab/nsp1374S74PTcaCca55R.10.00045
ORF1ab/nsp1374S74PTcaCca44AT.10.020513
ORF1ab/nsp1374S74PTcaCca44B.1.1.280.001245
ORF1ab/nsp1374S74PTcaCca44B.1.360.000584
ORF1ab/nsp1374S74PTcaCca44B.1.5950.001044
ORF1ab/nsp1374S74PTcaCca44B.1.6210.000354
ORF1ab/nsp1374S74PTcaCca33A.190.028302
ORF1ab/nsp1374S74PTcaCca33AY.30.00003
ORF1ab/nsp1374S74PTcaCca33AY.390.000074
ORF1ab/nsp1374S74PTcaCca33AY.9.10.000251
ORF1ab/nsp1374S74PTcaCca33B.1.1.1920.006928
ORF1ab/nsp1374S74PTcaCca33B.1.1.2940.003797
ORF1ab/nsp1374S74PTcaCca33B.1.1.3060.001315
ORF1ab/nsp1374S74PTcaCca33B.1.1.3370.010791
ORF1ab/nsp1374S74PTcaCca33B.1.1770.00004
ORF1ab/nsp1374S74PTcaCca33B.1.221.20.012048
ORF1ab/nsp1374S74PTcaCca33B.1.258.140.002941
ORF1ab/nsp1374S74PTcaCca33B.1.4270.000151
ORF1ab/nsp1374S74PTcaCca22AY.1020.000053
ORF1ab/nsp1374S74PTcaCca22AY.120.2.10.000997
ORF1ab/nsp1374S74PTcaCca22AY.3.10.000171
ORF1ab/nsp1374S74PTcaCca22AY.50.000041
ORF1ab/nsp1374S74PTcaCca22AY.740.000231
ORF1ab/nsp1374S74PTcaCca22B.1.1.2690.002706
ORF1ab/nsp1374S74PTcaCca22B.1.1.5210.010695
ORF1ab/nsp1374S74PTcaCca22B.1.1260.002551
ORF1ab/nsp1374S74PTcaCca22B.1.177.120.000303
ORF1ab/nsp1374S74PTcaCca22B.1.2340.000264
ORF1ab/nsp1374S74PTcaCca22B.1.2580.000133
ORF1ab/nsp1374S74PTcaCca22B.1.36.170.000988
ORF1ab/nsp1374S74PTcaCca22B.1.36.290.001035
ORF1ab/nsp1374S74PTcaCca22B.1.466.20.000782
ORF1ab/nsp1374S74PTcaCca22B.1.5260.000047
ORF1ab/nsp1374S74PTcaCca22B.1.5960.000174
ORF1ab/nsp1374S74PTcaCca22B.1.6090.000959
ORF1ab/nsp1374S74PTcaCca11A0.000387
ORF1ab/nsp1374S74PTcaCca11A.23.10.000704
ORF1ab/nsp1374S74PTcaCca11AY.1180.000063
ORF1ab/nsp1374S74PTcaCca11AY.1190.000035
ORF1ab/nsp1374S74PTcaCca11AY.270.000065
ORF1ab/nsp1374S74PTcaCca11AY.430.000004
ORF1ab/nsp1374S74PTcaCca11AY.450.000122
ORF1ab/nsp1374S74PTcaCca11AY.460.000104
ORF1ab/nsp1374S74PTcaCca11AY.540.000095
ORF1ab/nsp1374S74PTcaCca11AY.750.000056
ORF1ab/nsp1374S74PTcaCca11AY.830.001724
ORF1ab/nsp1374S74PTcaCca11AY.90.000068
ORF1ab/nsp1374S74PTcaCca11AY.9.20.000037
ORF1ab/nsp1374S74PTcaCca11B0.000128
ORF1ab/nsp1374S74PTcaCca11B.1.1.2610.008621
ORF1ab/nsp1374S74PTcaCca11B.1.1.3070.002532
ORF1ab/nsp1374S74PTcaCca11B.1.1.3660.015873
ORF1ab/nsp1374S74PTcaCca11B.1.1.3690.000446
ORF1ab/nsp1374S74PTcaCca11B.1.1.3720.000689
ORF1ab/nsp1374S74PTcaCca11B.1.1.4480.002033
ORF1ab/nsp1374S74PTcaCca11B.1.1.4670.019231
ORF1ab/nsp1374S74PTcaCca11B.1.1600.000031
ORF1ab/nsp1374S74PTcaCca11B.1.177.160.000664
ORF1ab/nsp1374S74PTcaCca11B.1.177.400.005155
ORF1ab/nsp1374S74PTcaCca11B.1.177.570.000281
ORF1ab/nsp1374S74PTcaCca11B.1.177.730.000566
ORF1ab/nsp1374S74PTcaCca11B.1.177.810.000189
ORF1ab/nsp1374S74PTcaCca11B.1.177.860.000183
ORF1ab/nsp1374S74PTcaCca11B.1.2400.000216
ORF1ab/nsp1374S74PTcaCca11B.1.2430.00007
ORF1ab/nsp1374S74PTcaCca11B.1.36.70.004
ORF1ab/nsp1374S74PTcaCca11B.1.3670.000792
ORF1ab/nsp1374S74PTcaCca11B.1.3690.000285
ORF1ab/nsp1374S74PTcaCca11B.1.4680.005714
ORF1ab/nsp1374S74PTcaCca11B.1.4970.000315
ORF1ab/nsp1374S74PTcaCca11B.1.5250.000113
ORF1ab/nsp1374S74PTcaCca11B.1.5750.000303
ORF1ab/nsp1374S74PTcaCca11B.1.6370.000073
ORF1ab/nsp1374S74PTcaCca11B.290.003509
ORF1ab/nsp1374S74PTcaCca11D.20.000075
ORF1ab/nsp1374S74PTcaCca11N.100.029412
ORF1ab/nsp1374S74PTcaCca11P.1.150.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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