CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = S74A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp1374S74AS5398AnonsynTcaGca1361340.98529416456-16458
ORF1ab/nsp1374S74AS5398AnonsynTcAGcG13620.014705916456-16458

Details of the mutation S74A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp1374S74ATcaGca134136All0.000026
ORF1ab/nsp1374S74ATcAGcG2136All0
ORF1ab/nsp1374S74ATcaGca3737AY.250.000223
ORF1ab/nsp1374S74ATcaGca2121B.10.000192
ORF1ab/nsp1374S74ATcaGca1818B.1.20.000158
ORF1ab/nsp1374S74ATcaGca77AY.30.00007
ORF1ab/nsp1374S74ATcaGca77AY.40.000011
ORF1ab/nsp1374S74ATcaGca66B.1.1.70.000005
ORF1ab/nsp1374S74ATcaGca66B.1.5960.000523
ORF1ab/nsp1374S74ATcaGca240.111111
ORF1ab/nsp1374S74ATcAGcG240.111111
ORF1ab/nsp1374S74ATcaGca44P.10.000063
ORF1ab/nsp1374S74ATcaGca33AY.4.2.10.000447
ORF1ab/nsp1374S74ATcaGca33AY.430.000013
ORF1ab/nsp1374S74ATcaGca33B.1.5260.000071
ORF1ab/nsp1374S74ATcaGca22B.1.1770.000026
ORF1ab/nsp1374S74ATcaGca22B.1.3910.002255
ORF1ab/nsp1374S74ATcaGca22B.1.4290.000047
ORF1ab/nsp1374S74ATcaGca11AY.440.000006
ORF1ab/nsp1374S74ATcaGca11B0.000128
ORF1ab/nsp1374S74ATcaGca11B.1.1.2140.000055
ORF1ab/nsp1374S74ATcaGca11B.1.1.3710.010417
ORF1ab/nsp1374S74ATcaGca11B.1.177.330.001645
ORF1ab/nsp1374S74ATcaGca11B.1.177.440.000519
ORF1ab/nsp1374S74ATcaGca11B.1.2580.000067
ORF1ab/nsp1374S74ATcaGca11B.1.3510.00003
ORF1ab/nsp1374S74ATcaGca11B.1.4270.00005
ORF1ab/nsp1374S74ATcaGca11B.1.617.20.000004
ORF1ab/nsp1374S74ATcaGca11P.1.10.000318

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.