CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = S166L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13166S166LS5490LnonsyntCatTa631663130.99952516732-16734
ORF1ab/nsp13166S166LS5490LnonsynTCACTT631620.00031665616732-16734
ORF1ab/nsp13166S166LS5490LnonsynTCACTG631610.00015832816732-16734

Details of the mutation S166L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13166S166LtCatTa63136316All0.001207
ORF1ab/nsp13166S166LTCACTT26316All0
ORF1ab/nsp13166S166LTCACTG16316All0
ORF1ab/nsp13166S166LtCatTa24972497B.1.1.70.002235
ORF1ab/nsp13166S166LtCatTa557557AY.30.00554
ORF1ab/nsp13166S166LtCatTa444444AY.40.000691
ORF1ab/nsp13166S166LtCatTa248248B.1.617.20.000934
ORF1ab/nsp13166S166LtCatTa201201AY.440.001223
ORF1ab/nsp13166S166LtCatTa196196B.1.20.001726
ORF1ab/nsp13166S166LtCatTa174174AY.250.001047
ORF1ab/nsp13166S166LtCatTa166166B.1.1600.005177
ORF1ab/nsp13166S166LtCatTa97100B.10.000888
ORF1ab/nsp13166S166LTCACTT2100B.10.000018
ORF1ab/nsp13166S166LTCACTG1100B.10.000009
ORF1ab/nsp13166S166LtCatTa8888AY.1030.000546
ORF1ab/nsp13166S166LtCatTa7878AY.60.003208
ORF1ab/nsp13166S166LtCatTa7676P.10.001197
ORF1ab/nsp13166S166LtCatTa6868B.1.595.10.397661
ORF1ab/nsp13166S166LtCatTa5656AY.1210.007578
ORF1ab/nsp13166S166LtCatTa5555AY.390.001359
ORF1ab/nsp13166S166LtCatTa5353AY.1130.007547
ORF1ab/nsp13166S166LtCatTa4848AY.430.000213
ORF1ab/nsp13166S166LtCatTa4848B.1.4290.001129
ORF1ab/nsp13166S166LtCatTa4848Q.80.007916
ORF1ab/nsp13166S166LtCatTa4444B.1.10.000798
ORF1ab/nsp13166S166LtCatTa2929AY.310.537037
ORF1ab/nsp13166S166LtCatTa2929B.1.1.5000.58
ORF1ab/nsp13166S166LtCatTa2929B.1.177.820.013842
ORF1ab/nsp13166S166LtCatTa2828B.1.1770.000369
ORF1ab/nsp13166S166LtCatTa2626B.1.2580.00173
ORF1ab/nsp13166S166LtCatTa2525AY.1020.000663
ORF1ab/nsp13166S166LtCatTa2525AY.1180.001566
ORF1ab/nsp13166S166LtCatTa2525B.1.2430.00174
ORF1ab/nsp13166S166LtCatTa2424B.1.5260.000564
ORF1ab/nsp13166S166LtCatTa2121AY.4.20.000455
ORF1ab/nsp13166S166LtCatTa2121B.1.3510.000624
ORF1ab/nsp13166S166LtCatTa2121C.370.002437
ORF1ab/nsp13166S166LtCatTa1919AY.420.000764
ORF1ab/nsp13166S166LtCatTa1919B.1.351.30.016652
ORF1ab/nsp13166S166LtCatTa1818AY.200.0007
ORF1ab/nsp13166S166LtCatTa1818B.1.5210.089552
ORF1ab/nsp13166S166LtCatTa1717AY.1200.000632
ORF1ab/nsp13166S166LtCatTa1616B.1.1.2220.003264
ORF1ab/nsp13166S166LtCatTa1515B.1.1.3300.9375
ORF1ab/nsp13166S166LtCatTa1313AY.1000.000598
ORF1ab/nsp13166S166LtCatTa1313AY.1190.000459
ORF1ab/nsp13166S166LtCatTa1212AY.50.000248
ORF1ab/nsp13166S166LtCatTa1212AY.740.001388
ORF1ab/nsp13166S166LtCatTa1212B.1.1.5190.000477
ORF1ab/nsp13166S166LtCatTa1111B.1.1.370.002122
ORF1ab/nsp13166S166LtCatTa1111B.1.177.560.007343
ORF1ab/nsp13166S166LtCatTa1010AY.3.10.000853
ORF1ab/nsp13166S166LtCatTa1010AY.330.000668
ORF1ab/nsp13166S166LtCatTa1010AY.90.000676
ORF1ab/nsp13166S166LtCatTa99AY.450.001095
ORF1ab/nsp13166S166LtCatTa99B.1.1.1890.013616
ORF1ab/nsp13166S166LtCatTa99B.1.360.001313
ORF1ab/nsp13166S166LtCatTa99B.1.5880.008189
ORF1ab/nsp13166S166LtCatTa99B.1.6200.008515
ORF1ab/nsp13166S166LtCatTa99Q.70.01
ORF1ab/nsp13166S166LtCatTa88AY.230.000558
ORF1ab/nsp13166S166LtCatTa88AY.290.000126
ORF1ab/nsp13166S166LtCatTa88AY.340.000776
ORF1ab/nsp13166S166LtCatTa88AY.46.60.000578
ORF1ab/nsp13166S166LtCatTa88B.1.1.280.00249
ORF1ab/nsp13166S166LtCatTa88B.1.36.290.004139
ORF1ab/nsp13166S166LtCatTa88B.1.6370.000585
ORF1ab/nsp13166S166LtCatTa77AE.80.003423
ORF1ab/nsp13166S166LtCatTa77AY.130.001127
ORF1ab/nsp13166S166LtCatTa77AY.9.20.000257
ORF1ab/nsp13166S166LtCatTa77B.1.160.140.014831
ORF1ab/nsp13166S166LtCatTa77B.1.438.10.000751
ORF1ab/nsp13166S166LtCatTa77P.1.140.000335
ORF1ab/nsp13166S166LtCatTa66A0.002322
ORF1ab/nsp13166S166LtCatTa66A.2.50.002994
ORF1ab/nsp13166S166LtCatTa66AY.260.00017
ORF1ab/nsp13166S166LtCatTa66AY.470.000187
ORF1ab/nsp13166S166LtCatTa66B.1.1.3040.016854
ORF1ab/nsp13166S166LtCatTa66B.1.177.570.001686
ORF1ab/nsp13166S166LtCatTa66B.1.2210.000426
ORF1ab/nsp13166S166LtCatTa66C.350.004644
ORF1ab/nsp13166S166LtCatTa55AY.140.00044
ORF1ab/nsp13166S166LtCatTa55AY.39.10.000198
ORF1ab/nsp13166S166LtCatTa55AY.510.004545
ORF1ab/nsp13166S166LtCatTa55AY.550.004587
ORF1ab/nsp13166S166LtCatTa55AY.610.000524
ORF1ab/nsp13166S166LtCatTa55AY.980.000395
ORF1ab/nsp13166S166LtCatTa55B.1.1.2160.004452
ORF1ab/nsp13166S166LtCatTa55B.1.4270.000252
ORF1ab/nsp13166S166LtCatTa55B.1.5960.000436
ORF1ab/nsp13166S166LtCatTa55D.20.000375
ORF1ab/nsp13166S166LtCatTa55P.1.10.001588
ORF1ab/nsp13166S166LtCatTa44A.280.010582
ORF1ab/nsp13166S166LtCatTa44AY.1060.00134
ORF1ab/nsp13166S166LtCatTa44AY.1100.000451
ORF1ab/nsp13166S166LtCatTa44AY.120.10.001284
ORF1ab/nsp13166S166LtCatTa44AY.460.000416
ORF1ab/nsp13166S166LtCatTa44AY.98.10.000194
ORF1ab/nsp13166S166LtCatTa44B.1.1.2140.000222
ORF1ab/nsp13166S166LtCatTa44B.1.1.700.001364
ORF1ab/nsp13166S166LtCatTa44B.1.36.190.037037
ORF1ab/nsp13166S166LtCatTa44B.1.4280.004082
ORF1ab/nsp13166S166LtCatTa44B.1.4740.007605
ORF1ab/nsp13166S166LtCatTa44B.1.617.10.000516
ORF1ab/nsp13166S166LtCatTa44B.1.6210.000354
ORF1ab/nsp13166S166LtCatTa33AY.1140.000693
ORF1ab/nsp13166S166LtCatTa33AY.1170.000254
ORF1ab/nsp13166S166LtCatTa33AY.120.2.10.001495
ORF1ab/nsp13166S166LtCatTa33AY.160.001139
ORF1ab/nsp13166S166LtCatTa33AY.270.000194
ORF1ab/nsp13166S166LtCatTa33AY.750.000168
ORF1ab/nsp13166S166LtCatTa33B.1.1.100.003344
ORF1ab/nsp13166S166LtCatTa33B.1.1.1700.003741
ORF1ab/nsp13166S166LtCatTa33B.1.1110.003525
ORF1ab/nsp13166S166LtCatTa33B.1.1460.012712
ORF1ab/nsp13166S166LtCatTa33B.1.177.210.000229
ORF1ab/nsp13166S166LtCatTa33B.1.177.400.015464
ORF1ab/nsp13166S166LtCatTa33B.1.177.600.000655
ORF1ab/nsp13166S166LtCatTa33B.1.177.800.005736
ORF1ab/nsp13166S166LtCatTa33B.1.177.860.00055
ORF1ab/nsp13166S166LtCatTa33B.1.2340.000396
ORF1ab/nsp13166S166LtCatTa33B.1.3670.002377
ORF1ab/nsp13166S166LtCatTa33B.1.4000.001287
ORF1ab/nsp13166S166LtCatTa33P.1.70.000958
ORF1ab/nsp13166S166LtCatTa22AY.10.000791
ORF1ab/nsp13166S166LtCatTa22AY.4.50.000215
ORF1ab/nsp13166S166LtCatTa22AY.46.20.001271
ORF1ab/nsp13166S166LtCatTa22AY.540.000191
ORF1ab/nsp13166S166LtCatTa22AY.620.000871
ORF1ab/nsp13166S166LtCatTa22AY.7.10.000225
ORF1ab/nsp13166S166LtCatTa22AY.9.10.000167
ORF1ab/nsp13166S166LtCatTa22B.1.1.10.000653
ORF1ab/nsp13166S166LtCatTa22B.1.1.1130.013986
ORF1ab/nsp13166S166LtCatTa22B.1.1.1610.007067
ORF1ab/nsp13166S166LtCatTa22B.1.1.2650.006309
ORF1ab/nsp13166S166LtCatTa22B.1.1.3060.000877
ORF1ab/nsp13166S166LtCatTa22B.1.1.3540.008772
ORF1ab/nsp13166S166LtCatTa22B.1.1.4160.00181
ORF1ab/nsp13166S166LtCatTa22B.1.1.460.008734
ORF1ab/nsp13166S166LtCatTa22B.1.130.004751
ORF1ab/nsp13166S166LtCatTa22B.1.177.100.001756
ORF1ab/nsp13166S166LtCatTa22B.1.177.150.001262
ORF1ab/nsp13166S166LtCatTa22B.1.177.170.001642
ORF1ab/nsp13166S166LtCatTa22B.1.177.720.00678
ORF1ab/nsp13166S166LtCatTa22B.1.177.730.001133
ORF1ab/nsp13166S166LtCatTa22B.1.258.70.003824
ORF1ab/nsp13166S166LtCatTa22B.1.2800.014286
ORF1ab/nsp13166S166LtCatTa22B.1.36.10.002281
ORF1ab/nsp13166S166LtCatTa22B.1.3690.00057
ORF1ab/nsp13166S166LtCatTa22B.1.3990.003868
ORF1ab/nsp13166S166LtCatTa22B.1.4260.002018
ORF1ab/nsp13166S166LtCatTa22B.1.5170.000854
ORF1ab/nsp13166S166LtCatTa22B.1.5560.015038
ORF1ab/nsp13166S166LtCatTa22B.1.5750.000607
ORF1ab/nsp13166S166LtCatTa11A.10.000282
ORF1ab/nsp13166S166LtCatTa11A.2.40.003367
ORF1ab/nsp13166S166LtCatTa11A.230.010526
ORF1ab/nsp13166S166LtCatTa11AA.10.007246
ORF1ab/nsp13166S166LtCatTa11AY.1160.000287
ORF1ab/nsp13166S166LtCatTa11AY.120.000316
ORF1ab/nsp13166S166LtCatTa11AY.240.000431
ORF1ab/nsp13166S166LtCatTa11AY.280.00189
ORF1ab/nsp13166S166LtCatTa11AY.34.10.00051
ORF1ab/nsp13166S166LtCatTa11AY.350.000233
ORF1ab/nsp13166S166LtCatTa11AY.4.2.10.000149
ORF1ab/nsp13166S166LtCatTa11AY.410.000294
ORF1ab/nsp13166S166LtCatTa11AY.46.30.000934
ORF1ab/nsp13166S166LtCatTa11AY.5.40.000277
ORF1ab/nsp13166S166LtCatTa11AY.570.000656
ORF1ab/nsp13166S166LtCatTa11AY.770.001127
ORF1ab/nsp13166S166LtCatTa11AY.790.001211
ORF1ab/nsp13166S166LtCatTa11AY.820.001357
ORF1ab/nsp13166S166LtCatTa11AY.840.000437
ORF1ab/nsp13166S166LtCatTa11AY.870.000833
ORF1ab/nsp13166S166LtCatTa11AY.920.000287
ORF1ab/nsp13166S166LtCatTa11AY.940.000443
ORF1ab/nsp13166S166LtCatTa11AY.99.20.000092
ORF1ab/nsp13166S166LtCatTa11AZ.20.000821
ORF1ab/nsp13166S166LtCatTa11B.1.1.1570.000913
ORF1ab/nsp13166S166LtCatTa11B.1.1.1710.003676
ORF1ab/nsp13166S166LtCatTa11B.1.1.1980.001468
ORF1ab/nsp13166S166LtCatTa11B.1.1.2170.003636
ORF1ab/nsp13166S166LtCatTa11B.1.1.2200.001859
ORF1ab/nsp13166S166LtCatTa11B.1.1.3050.003861
ORF1ab/nsp13166S166LtCatTa11B.1.1.3110.000358
ORF1ab/nsp13166S166LtCatTa11B.1.1.3120.001912
ORF1ab/nsp13166S166LtCatTa11B.1.1.3260.001761
ORF1ab/nsp13166S166LtCatTa11B.1.1.330.000421
ORF1ab/nsp13166S166LtCatTa11B.1.1.3710.010417
ORF1ab/nsp13166S166LtCatTa11B.1.1.3890.006061
ORF1ab/nsp13166S166LtCatTa11B.1.1.3970.002252
ORF1ab/nsp13166S166LtCatTa11B.1.1.4340.000349
ORF1ab/nsp13166S166LtCatTa11B.1.1.4660.008696
ORF1ab/nsp13166S166LtCatTa11B.1.1.500.000679
ORF1ab/nsp13166S166LtCatTa11B.1.1.510.001718
ORF1ab/nsp13166S166LtCatTa11B.1.1.5230.001563
ORF1ab/nsp13166S166LtCatTa11B.1.1.5260.003546
ORF1ab/nsp13166S166LtCatTa11B.1.1.630.000386
ORF1ab/nsp13166S166LtCatTa11B.1.1.770.041667
ORF1ab/nsp13166S166LtCatTa11B.1.1190.010526
ORF1ab/nsp13166S166LtCatTa11B.1.177.120.000152
ORF1ab/nsp13166S166LtCatTa11B.1.177.40.000211
ORF1ab/nsp13166S166LtCatTa11B.1.177.450.000381
ORF1ab/nsp13166S166LtCatTa11B.1.177.50.001242
ORF1ab/nsp13166S166LtCatTa11B.1.177.520.001757
ORF1ab/nsp13166S166LtCatTa11B.1.177.540.000606
ORF1ab/nsp13166S166LtCatTa11B.1.177.810.000189
ORF1ab/nsp13166S166LtCatTa11B.1.177.850.005435
ORF1ab/nsp13166S166LtCatTa11B.1.177.870.000728
ORF1ab/nsp13166S166LtCatTa11B.1.1990.004132
ORF1ab/nsp13166S166LtCatTa11B.1.2100.002132
ORF1ab/nsp13166S166LtCatTa11B.1.2360.002053
ORF1ab/nsp13166S166LtCatTa11B.1.2390.001221
ORF1ab/nsp13166S166LtCatTa11B.1.258.170.000104
ORF1ab/nsp13166S166LtCatTa11B.1.258.220.002667
ORF1ab/nsp13166S166LtCatTa11B.1.3140.007519
ORF1ab/nsp13166S166LtCatTa11B.1.3190.003049
ORF1ab/nsp13166S166LtCatTa11B.1.3290.000608
ORF1ab/nsp13166S166LtCatTa11B.1.3440.008197
ORF1ab/nsp13166S166LtCatTa11B.1.351.20.000303
ORF1ab/nsp13166S166LtCatTa11B.1.351.50.0006
ORF1ab/nsp13166S166LtCatTa11B.1.3560.001727
ORF1ab/nsp13166S166LtCatTa11B.1.36.220.001208
ORF1ab/nsp13166S166LtCatTa11B.1.36.370.002778
ORF1ab/nsp13166S166LtCatTa11B.1.36.380.001642
ORF1ab/nsp13166S166LtCatTa11B.1.36.80.001
ORF1ab/nsp13166S166LtCatTa11B.1.3710.001122
ORF1ab/nsp13166S166LtCatTa11B.1.3750.00082
ORF1ab/nsp13166S166LtCatTa11B.1.3780.006849
ORF1ab/nsp13166S166LtCatTa11B.1.3960.000706
ORF1ab/nsp13166S166LtCatTa11B.1.4200.010417
ORF1ab/nsp13166S166LtCatTa11B.1.4590.004082
ORF1ab/nsp13166S166LtCatTa11B.1.4620.007246
ORF1ab/nsp13166S166LtCatTa11B.1.4650.003802
ORF1ab/nsp13166S166LtCatTa11B.1.466.20.000391
ORF1ab/nsp13166S166LtCatTa11B.1.4800.002488
ORF1ab/nsp13166S166LtCatTa11B.1.5250.000113
ORF1ab/nsp13166S166LtCatTa11B.1.5330.009615
ORF1ab/nsp13166S166LtCatTa11B.1.5510.00129
ORF1ab/nsp13166S166LtCatTa11B.1.5540.004405
ORF1ab/nsp13166S166LtCatTa11B.1.5580.004566
ORF1ab/nsp13166S166LtCatTa11B.1.5640.000426
ORF1ab/nsp13166S166LtCatTa11B.1.5700.002941
ORF1ab/nsp13166S166LtCatTa11B.1.575.10.002439
ORF1ab/nsp13166S166LtCatTa11B.1.5760.000907
ORF1ab/nsp13166S166LtCatTa11B.1.5770.000687
ORF1ab/nsp13166S166LtCatTa11B.1.6270.00202
ORF1ab/nsp13166S166LtCatTa11B.1.6280.000352
ORF1ab/nsp13166S166LtCatTa11B.1.6360.006711
ORF1ab/nsp13166S166LtCatTa11B.400.000364
ORF1ab/nsp13166S166LtCatTa11B.60.00091
ORF1ab/nsp13166S166LtCatTa11C.180.002591
ORF1ab/nsp13166S166LtCatTa11C.190.027027
ORF1ab/nsp13166S166LtCatTa11N.60.007092
ORF1ab/nsp13166S166LtCatTa11P.1.130.000898
ORF1ab/nsp13166S166LtCatTa11P.1.170.000162
ORF1ab/nsp13166S166LtCatTa11P.20.000187
ORF1ab/nsp13166S166LtCatTa11P.30.001595
ORF1ab/nsp13166S166LtCatTa11Q.10.000126
ORF1ab/nsp13166S166LtCatTa11Q.30.000145
ORF1ab/nsp13166S166LtCatTa11Q.40.000455
ORF1ab/nsp13166S166LtCatTa11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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