CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = P504L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13504P504LP5828LnonsyncCtcTt912791250.99978117746-17748
ORF1ab/nsp13504P504LP5828LnonsyncCTcTC912710.00010956517746-17748
ORF1ab/nsp13504P504LP5828LnonsyncCTcTA912710.00010956517746-17748

Details of the mutation P504L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13504P504LcCtcTt91259127All0.001745
ORF1ab/nsp13504P504LcCTcTC19127All0
ORF1ab/nsp13504P504LcCTcTA19127All0
ORF1ab/nsp13504P504LcCtcTt33543354A.10.945321
ORF1ab/nsp13504P504LcCtcTt12671267AY.40.001972
ORF1ab/nsp13504P504LcCtcTt743743AY.4.2.10.110697
ORF1ab/nsp13504P504LcCtcTt644644B.1.1.70.000577
ORF1ab/nsp13504P504LcCtcTt559559B.1.20.004922
ORF1ab/nsp13504P504LcCtcTt375375B.1.617.20.001412
ORF1ab/nsp13504P504LcCtcTt127127AY.1030.000789
ORF1ab/nsp13504P504LcCtcTt126127B.1.5260.002962
ORF1ab/nsp13504P504LcCTcTC1127B.1.5260.000024
ORF1ab/nsp13504P504LcCtcTt9797B.10.000888
ORF1ab/nsp13504P504LcCtcTt8888B.1.10.001596
ORF1ab/nsp13504P504LcCtcTt7979AY.430.00035
ORF1ab/nsp13504P504LcCtcTt7676B.1.3060.434286
ORF1ab/nsp13504P504LcCtcTt6565B.1.36.310.113835
ORF1ab/nsp13504P504LcCtcTt5757AY.290.000899
ORF1ab/nsp13504P504LcCtcTt5252AY.250.000313
ORF1ab/nsp13504P504LcCtcTt5050AY.30.000497
ORF1ab/nsp13504P504LcCtcTt5050B.1.3690.014261
ORF1ab/nsp13504P504LcCtcTt4444P.10.000693
ORF1ab/nsp13504P504LcCtcTt4040AY.1210.005413
ORF1ab/nsp13504P504LcCtcTt3838AY.4.20.000824
ORF1ab/nsp13504P504LcCtcTt3737AY.390.000914
ORF1ab/nsp13504P504LcCtcTt3737B.1.177.180.042923
ORF1ab/nsp13504P504LcCtcTt3737B.1.2430.002575
ORF1ab/nsp13504P504LcCtcTt3535AY.1020.000928
ORF1ab/nsp13504P504LcCtcTt3434AY.99.20.003133
ORF1ab/nsp13504P504LcCtcTt3333B.1.2210.002344
ORF1ab/nsp13504P504LcCtcTt3232B.1.1770.000421
ORF1ab/nsp13504P504LcCtcTt2828AY.440.00017
ORF1ab/nsp13504P504LcCtcTt2727AY.200.001049
ORF1ab/nsp13504P504LcCtcTt2424B.1.1.5190.000953
ORF1ab/nsp13504P504LcCtcTt2424B.1.3510.000713
ORF1ab/nsp13504P504LcCtcTt2323AY.1000.001058
ORF1ab/nsp13504P504LcCtcTt2323AY.460.002394
ORF1ab/nsp13504P504LcCtcTt2121AY.1100.002366
ORF1ab/nsp13504P504LcCtcTt2121AY.630.008124
ORF1ab/nsp13504P504LcCtcTt2121B.1.4270.00106
ORF1ab/nsp13504P504LcCtcTt1919AY.420.000764
ORF1ab/nsp13504P504LcCtcTt1919AY.50.000392
ORF1ab/nsp13504P504LcCtcTt1919B.1.1600.000593
ORF1ab/nsp13504P504LcCtcTt1919P.1.100.00512
ORF1ab/nsp13504P504LcCtcTt1616B.1.4290.000376
ORF1ab/nsp13504P504LcCtcTt1616B.1.6210.001416
ORF1ab/nsp13504P504LcCtcTt1515A0.005805
ORF1ab/nsp13504P504LcCtcTt1515AY.1190.00053
ORF1ab/nsp13504P504LcCtcTt1414B.1.1.3920.736842
ORF1ab/nsp13504P504LcCtcTt1414B.1.177.190.020029
ORF1ab/nsp13504P504LcCtcTt1414B.1.5820.006869
ORF1ab/nsp13504P504LcCtcTt1414P.1.140.000669
ORF1ab/nsp13504P504LcCtcTt1212AY.330.000801
ORF1ab/nsp13504P504LcCtcTt1111AY.1200.000409
ORF1ab/nsp13504P504LcCtcTt1111AY.260.000311
ORF1ab/nsp13504P504LcCtcTt1010AY.4.50.001075
ORF1ab/nsp13504P504LcCtcTt1010P.70.043668
ORF1ab/nsp13504P504LcCtcTt99B.1.1.2910.006682
ORF1ab/nsp13504P504LcCtcTt99B.1.2580.000599
ORF1ab/nsp13504P504LcCtcTt99B.1.360.001313
ORF1ab/nsp13504P504LcCtcTt88AY.1130.001139
ORF1ab/nsp13504P504LcCtcTt88AY.1180.000501
ORF1ab/nsp13504P504LcCtcTt88AY.470.000249
ORF1ab/nsp13504P504LcCtcTt88AY.9.20.000294
ORF1ab/nsp13504P504LcCtcTt88B.1.177.230.02589
ORF1ab/nsp13504P504LcCtcTt88B.1.6370.000585
ORF1ab/nsp13504P504LcCtcTt77AY.70.001372
ORF1ab/nsp13504P504LcCtcTt77AY.740.00081
ORF1ab/nsp13504P504LcCtcTt77B.1.1.280.002179
ORF1ab/nsp13504P504LcCtcTt77B.1.177.810.001325
ORF1ab/nsp13504P504LcCtcTt77B.1.4090.005469
ORF1ab/nsp13504P504LcCtcTt77D.20.000525
ORF1ab/nsp13504P504LcCtcTt66AY.1150.03125
ORF1ab/nsp13504P504LcCtcTt66AY.230.000418
ORF1ab/nsp13504P504LcCtcTt66AY.80.003636
ORF1ab/nsp13504P504LcCtcTt66B.1.3670.004754
ORF1ab/nsp13504P504LcCtcTt66B.390.013986
ORF1ab/nsp13504P504LcCtcTt66P.1.10.10.04878
ORF1ab/nsp13504P504LcCtcTt55AY.29.10.001103
ORF1ab/nsp13504P504LcCtcTt55AY.340.000485
ORF1ab/nsp13504P504LcCtcTt55AY.370.00158
ORF1ab/nsp13504P504LcCtcTt55AY.980.000395
ORF1ab/nsp13504P504LcCtcTt55AZ.30.007599
ORF1ab/nsp13504P504LcCtcTt55B.1.1.1920.011547
ORF1ab/nsp13504P504LcCtcTt55B.1.1.2070.00591
ORF1ab/nsp13504P504LcCtcTt55B.1.160.70.010395
ORF1ab/nsp13504P504LcCtcTt55B.1.36.80.005
ORF1ab/nsp13504P504LcCtcTt55B.1.3960.003529
ORF1ab/nsp13504P504LcCtcTt44AY.10.001583
ORF1ab/nsp13504P504LcCtcTt44AY.1160.001147
ORF1ab/nsp13504P504LcCtcTt44AY.380.001997
ORF1ab/nsp13504P504LcCtcTt44AY.39.10.000158
ORF1ab/nsp13504P504LcCtcTt44AY.75.10.000721
ORF1ab/nsp13504P504LcCtcTt44AY.9.10.000335
ORF1ab/nsp13504P504LcCtcTt44AY.98.10.000194
ORF1ab/nsp13504P504LcCtcTt44B.1.1.2860.011594
ORF1ab/nsp13504P504LcCtcTt44B.1.1.330.001684
ORF1ab/nsp13504P504LcCtcTt44B.1.1.3480.003185
ORF1ab/nsp13504P504LcCtcTt44B.1.1.5250.021858
ORF1ab/nsp13504P504LcCtcTt44B.1.2320.002149
ORF1ab/nsp13504P504LcCtcTt44B.1.258.140.003922
ORF1ab/nsp13504P504LcCtcTt44B.1.258.170.000416
ORF1ab/nsp13504P504LcCtcTt44B.1.4000.001716
ORF1ab/nsp13504P504LcCtcTt44B.1.438.10.000429
ORF1ab/nsp13504P504LcCtcTt44B.1.6090.001918
ORF1ab/nsp13504P504LcCtcTt44R.10.00036
ORF1ab/nsp13504P504LcCtcTt33A.2.50.001497
ORF1ab/nsp13504P504LcCtcTt33AY.1140.000693
ORF1ab/nsp13504P504LcCtcTt33AY.140.000264
ORF1ab/nsp13504P504LcCtcTt33AY.210.005693
ORF1ab/nsp13504P504LcCtcTt33AY.220.006276
ORF1ab/nsp13504P504LcCtcTt33AY.46.60.000217
ORF1ab/nsp13504P504LcCtcTt33AY.60.000123
ORF1ab/nsp13504P504LcCtcTt33AY.660.003209
ORF1ab/nsp13504P504LcCtcTt33AY.900.002053
ORF1ab/nsp13504P504LcCtcTt33B0.000383
ORF1ab/nsp13504P504LcCtcTt33B.1.1.10.00098
ORF1ab/nsp13504P504LcCtcTt33B.1.177.40.000633
ORF1ab/nsp13504P504LcCtcTt33B.1.177.570.000843
ORF1ab/nsp13504P504LcCtcTt33B.1.177.620.003576
ORF1ab/nsp13504P504LcCtcTt33B.1.2400.000647
ORF1ab/nsp13504P504LcCtcTt33B.1.2810.065217
ORF1ab/nsp13504P504LcCtcTt33B.1.36.170.001482
ORF1ab/nsp13504P504LcCtcTt33B.1.5960.000261
ORF1ab/nsp13504P504LcCtcTt22A.280.005291
ORF1ab/nsp13504P504LcCtcTt22AU.10.002532
ORF1ab/nsp13504P504LcCtcTt22AY.1080.002205
ORF1ab/nsp13504P504LcCtcTt22AY.120.10.000642
ORF1ab/nsp13504P504LcCtcTt22AY.130.000322
ORF1ab/nsp13504P504LcCtcTt22AY.350.000466
ORF1ab/nsp13504P504LcCtcTt22AY.5.30.000675
ORF1ab/nsp13504P504LcCtcTt22AY.540.000191
ORF1ab/nsp13504P504LcCtcTt22AY.550.001835
ORF1ab/nsp13504P504LcCtcTt22AY.610.00021
ORF1ab/nsp13504P504LcCtcTt22AY.910.001461
ORF1ab/nsp13504P504LcCtcTt22AY.990.002099
ORF1ab/nsp13504P504LcCtcTt22AZ.20.001642
ORF1ab/nsp13504P504LcCtcTt22B.1.1.2140.000111
ORF1ab/nsp13504P504LcCtcTt22B.1.1.260.010471
ORF1ab/nsp13504P504LcCtcTt22B.1.1.3040.005618
ORF1ab/nsp13504P504LcCtcTt22B.1.1.3180.000604
ORF1ab/nsp13504P504LcCtcTt22B.1.1.3260.003521
ORF1ab/nsp13504P504LcCtcTt22B.1.1.3330.002153
ORF1ab/nsp13504P504LcCtcTt22B.1.1.3890.012121
ORF1ab/nsp13504P504LcCtcTt22B.1.1.4610.024096
ORF1ab/nsp13504P504LcCtcTt22B.1.1.5230.003125
ORF1ab/nsp13504P504LcCtcTt22B.1.1.700.000682
ORF1ab/nsp13504P504LcCtcTt22B.1.177.820.000955
ORF1ab/nsp13504P504LcCtcTt22B.1.2340.000264
ORF1ab/nsp13504P504LcCtcTt22B.1.2410.001623
ORF1ab/nsp13504P504LcCtcTt22B.1.4320.022472
ORF1ab/nsp13504P504LcCtcTt22B.1.4480.005249
ORF1ab/nsp13504P504LcCtcTt22B.1.5750.000607
ORF1ab/nsp13504P504LcCtcTt22B.1.6310.006734
ORF1ab/nsp13504P504LcCtcTt22B.1.910.004149
ORF1ab/nsp13504P504LcCtcTt22P.20.000373
ORF1ab/nsp13504P504LcCtcTt22Q.10.000253
ORF1ab/nsp13504P504LcCtcTt11A.180.05
ORF1ab/nsp13504P504LcCtcTt11A.2.5.10.004808
ORF1ab/nsp13504P504LcCtcTt11A.240.071429
ORF1ab/nsp13504P504LcCtcTt11AY.1010.00049
ORF1ab/nsp13504P504LcCtcTt11AY.1090.00074
ORF1ab/nsp13504P504LcCtcTt11AY.1110.000183
ORF1ab/nsp13504P504LcCtcTt11AY.116.10.000311
ORF1ab/nsp13504P504LcCtcTt11AY.1170.000085
ORF1ab/nsp13504P504LcCtcTt11AY.16.10.00047
ORF1ab/nsp13504P504LcCtcTt11AY.23.10.000417
ORF1ab/nsp13504P504LcCtcTt11AY.270.000065
ORF1ab/nsp13504P504LcCtcTt11AY.3.10.000085
ORF1ab/nsp13504P504LcCtcTt11AY.360.000148
ORF1ab/nsp13504P504LcCtcTt11AY.450.000122
ORF1ab/nsp13504P504LcCtcTt11AY.46.40.000165
ORF1ab/nsp13504P504LcCtcTt11AY.560.001605
ORF1ab/nsp13504P504LcCtcTt11AY.570.000656
ORF1ab/nsp13504P504LcCtcTt11AY.590.00053
ORF1ab/nsp13504P504LcCtcTt11AY.600.000938
ORF1ab/nsp13504P504LcCtcTt11AY.620.000436
ORF1ab/nsp13504P504LcCtcTt11AY.680.000274
ORF1ab/nsp13504P504LcCtcTt11AY.690.000187
ORF1ab/nsp13504P504LcCtcTt11AY.7.10.000113
ORF1ab/nsp13504P504LcCtcTt11AY.700.000209
ORF1ab/nsp13504P504LcCtcTt11AY.710.000475
ORF1ab/nsp13504P504LcCtcTt11AY.770.001127
ORF1ab/nsp13504P504LcCTcTA11AY.850.000427
ORF1ab/nsp13504P504LcCtcTt11AY.860.00083
ORF1ab/nsp13504P504LcCtcTt11AY.930.000273
ORF1ab/nsp13504P504LcCtcTt11AZ.2.10.00813
ORF1ab/nsp13504P504LcCtcTt11B.1.1.1760.000439
ORF1ab/nsp13504P504LcCtcTt11B.1.1.1890.001513
ORF1ab/nsp13504P504LcCtcTt11B.1.1.2220.000204
ORF1ab/nsp13504P504LcCtcTt11B.1.1.2690.001353
ORF1ab/nsp13504P504LcCtcTt11B.1.1.2840.000107
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3080.011765
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3110.000358
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3160.000925
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3220.008772
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3720.000689
ORF1ab/nsp13504P504LcCtcTt11B.1.1.3830.0625
ORF1ab/nsp13504P504LcCtcTt11B.1.1.4090.002833
ORF1ab/nsp13504P504LcCtcTt11B.1.1.4340.000349
ORF1ab/nsp13504P504LcCtcTt11B.1.1.500.000679
ORF1ab/nsp13504P504LcCtcTt11B.1.1.5280.004808
ORF1ab/nsp13504P504LcCtcTt11B.1.1.630.000386
ORF1ab/nsp13504P504LcCtcTt11B.1.1040.00369
ORF1ab/nsp13504P504LcCtcTt11B.1.1110.001175
ORF1ab/nsp13504P504LcCtcTt11B.1.177.330.001645
ORF1ab/nsp13504P504LcCtcTt11B.1.177.420.000894
ORF1ab/nsp13504P504LcCtcTt11B.1.177.50.001242
ORF1ab/nsp13504P504LcCtcTt11B.1.177.60.000977
ORF1ab/nsp13504P504LcCtcTt11B.1.177.690.001484
ORF1ab/nsp13504P504LcCtcTt11B.1.177.70.000165
ORF1ab/nsp13504P504LcCtcTt11B.1.177.750.001041
ORF1ab/nsp13504P504LcCtcTt11B.1.177.870.000728
ORF1ab/nsp13504P504LcCtcTt11B.1.2390.001221
ORF1ab/nsp13504P504LcCtcTt11B.1.258.20.004505
ORF1ab/nsp13504P504LcCtcTt11B.1.3150.006061
ORF1ab/nsp13504P504LcCtcTt11B.1.3240.001605
ORF1ab/nsp13504P504LcCtcTt11B.1.351.30.000876
ORF1ab/nsp13504P504LcCtcTt11B.1.3560.001727
ORF1ab/nsp13504P504LcCtcTt11B.1.36.10.00114
ORF1ab/nsp13504P504LcCtcTt11B.1.36.100.004785
ORF1ab/nsp13504P504LcCtcTt11B.1.36.290.000517
ORF1ab/nsp13504P504LcCtcTt11B.1.36.360.000602
ORF1ab/nsp13504P504LcCtcTt11B.1.3980.002976
ORF1ab/nsp13504P504LcCtcTt11B.1.3990.001934
ORF1ab/nsp13504P504LcCtcTt11B.1.4080.00369
ORF1ab/nsp13504P504LcCtcTt11B.1.4160.001269
ORF1ab/nsp13504P504LcCtcTt11B.1.4700.001404
ORF1ab/nsp13504P504LcCtcTt11B.1.4990.00105
ORF1ab/nsp13504P504LcCtcTt11B.1.5060.02381
ORF1ab/nsp13504P504LcCtcTt11B.1.5250.000113
ORF1ab/nsp13504P504LcCtcTt11B.1.5740.002151
ORF1ab/nsp13504P504LcCtcTt11B.1.5950.000261
ORF1ab/nsp13504P504LcCtcTt11B.1.5990.00365
ORF1ab/nsp13504P504LcCtcTt11B.1.617.10.000129
ORF1ab/nsp13504P504LcCtcTt11B.1.6190.000871
ORF1ab/nsp13504P504LcCtcTt11B.1.619.10.000641
ORF1ab/nsp13504P504LcCtcTt11B.1.621.10.000506
ORF1ab/nsp13504P504LcCtcTt11B.1.6280.000352
ORF1ab/nsp13504P504LcCtcTt11B.40.002208
ORF1ab/nsp13504P504LcCtcTt11B.410.008
ORF1ab/nsp13504P504LcCtcTt11C.1.20.004255
ORF1ab/nsp13504P504LcCtcTt11C.36.30.000567
ORF1ab/nsp13504P504LcCtcTt11C.370.000116
ORF1ab/nsp13504P504LcCtcTt11C.37.10.002618
ORF1ab/nsp13504P504LcCtcTt11L.30.003546
ORF1ab/nsp13504P504LcCtcTt11N.50.001767
ORF1ab/nsp13504P504LcCtcTt11P.1.120.000484
ORF1ab/nsp13504P504LcCtcTt11P.1.170.000162
ORF1ab/nsp13504P504LcCtcTt11P.1.40.000977
ORF1ab/nsp13504P504LcCtcTt11Q.40.000455
ORF1ab/nsp13504P504LcCtcTt11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.