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CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = N124S

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13124N124SN5448SnonsynaAcaGc207207116606-16608

Details of the mutation N124S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13124N124SaAcaGc207207All0.00004
ORF1ab/nsp13124N124SaAcaGc5454AY.50.001115
ORF1ab/nsp13124N124SaAcaGc5252P.1.170.008412
ORF1ab/nsp13124N124SaAcaGc2626B.1.1.1970.962963
ORF1ab/nsp13124N124SaAcaGc1414B.1.1.70.000013
ORF1ab/nsp13124N124SaAcaGc77AY.260.000198
ORF1ab/nsp13124N124SaAcaGc55AY.140.00044
ORF1ab/nsp13124N124SaAcaGc55AY.30.00005
ORF1ab/nsp13124N124SaAcaGc44B.1.617.20.000015
ORF1ab/nsp13124N124SaAcaGc33AY.40.000005
ORF1ab/nsp13124N124SaAcaGc33B.1.1.1570.00274
ORF1ab/nsp13124N124SaAcaGc33B.1.1.2140.000166
ORF1ab/nsp13124N124SaAcaGc33B.1.1770.00004
ORF1ab/nsp13124N124SaAcaGc33B.1.20.000026
ORF1ab/nsp13124N124SaAcaGc22AY.390.000049
ORF1ab/nsp13124N124SaAcaGc22AY.5.40.000553
ORF1ab/nsp13124N124SaAcaGc22B.10.000018
ORF1ab/nsp13124N124SaAcaGc22B.1.10.000036
ORF1ab/nsp13124N124SaAcaGc22P.10.000032
ORF1ab/nsp13124N124SaAcaGc11A.2.40.003367
ORF1ab/nsp13124N124SaAcaGc11AY.1030.000006
ORF1ab/nsp13124N124SaAcaGc11AY.250.000006
ORF1ab/nsp13124N124SaAcaGc11AY.430.000004
ORF1ab/nsp13124N124SaAcaGc11AY.440.000006
ORF1ab/nsp13124N124SaAcaGc11AY.9.20.000037
ORF1ab/nsp13124N124SaAcaGc11AY.990.001049
ORF1ab/nsp13124N124SaAcaGc11AY.99.20.000092
ORF1ab/nsp13124N124SaAcaGc11B.1.1600.000031
ORF1ab/nsp13124N124SaAcaGc11B.1.177.560.000668
ORF1ab/nsp13124N124SaAcaGc11B.1.2400.000216
ORF1ab/nsp13124N124SaAcaGc11B.1.4290.000024
ORF1ab/nsp13124N124SaAcaGc11B.1.5260.000024
ORF1ab/nsp13124N124SaAcaGc11P.1.100.000269
ORF1ab/nsp13124N124SaAcaGc11P.1.150.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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