CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = L295L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13295L295LL5619LsynCtaTta324028950.89351917119-17121
ORF1ab/nsp13295L295LL5619LsynctActT32402050.063271617119-17121
ORF1ab/nsp13295L295LL5619LsynctActG32401220.037654317119-17121
ORF1ab/nsp13295L295LL5619LsynctActC3240180.0055555617119-17121

Details of the mutation L295L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13295L295LCtaTta28953240All0.000554
ORF1ab/nsp13295L295LctActT2053240All0.000039
ORF1ab/nsp13295L295LctActG1223240All0.000023
ORF1ab/nsp13295L295LctActC183240All0.000003
ORF1ab/nsp13295L295LCtaTta15631636B.1.1.70.001399
ORF1ab/nsp13295L295LctActG381636B.1.1.70.000034
ORF1ab/nsp13295L295LctActT321636B.1.1.70.000029
ORF1ab/nsp13295L295LctActC31636B.1.1.70.000003
ORF1ab/nsp13295L295LCtaTta249287AY.40.000388
ORF1ab/nsp13295L295LctActT31287AY.40.000048
ORF1ab/nsp13295L295LctActG6287AY.40.000009
ORF1ab/nsp13295L295LctActC1287AY.40.000002
ORF1ab/nsp13295L295LCtaTta206208AY.250.001239
ORF1ab/nsp13295L295LctActT2208AY.250.000012
ORF1ab/nsp13295L295LCtaTta130156B.1.20.001145
ORF1ab/nsp13295L295LctActG22156B.1.20.000194
ORF1ab/nsp13295L295LctActT2156B.1.20.000018
ORF1ab/nsp13295L295LctActC2156B.1.20.000018
ORF1ab/nsp13295L295LCtaTta93105B.1.617.20.00035
ORF1ab/nsp13295L295LctActT7105B.1.617.20.000026
ORF1ab/nsp13295L295LctActG5105B.1.617.20.000019
ORF1ab/nsp13295L295LctActT4676AY.430.000204
ORF1ab/nsp13295L295LCtaTta2876AY.430.000124
ORF1ab/nsp13295L295LctActC176AY.430.000004
ORF1ab/nsp13295L295LctActG176AY.430.000004
ORF1ab/nsp13295L295LCtaTta5969AY.440.000359
ORF1ab/nsp13295L295LctActT769AY.440.000043
ORF1ab/nsp13295L295LctActG269AY.440.000012
ORF1ab/nsp13295L295LctActC169AY.440.000006
ORF1ab/nsp13295L295LCtaTta6161B.1.177.570.01714
ORF1ab/nsp13295L295LctActT3435B.1.5750.010316
ORF1ab/nsp13295L295LCtaTta135B.1.5750.000303
ORF1ab/nsp13295L295LCtaTta3434P.1.140.001625
ORF1ab/nsp13295L295LCtaTta2932B.1.1770.000382
ORF1ab/nsp13295L295LctActG232B.1.1770.000026
ORF1ab/nsp13295L295LctActT132B.1.1770.000013
ORF1ab/nsp13295L295LCtaTta2727AY.4.20.000586
ORF1ab/nsp13295L295LCtaTta2123AY.1030.00013
ORF1ab/nsp13295L295LctActG223AY.1030.000012
ORF1ab/nsp13295L295LCtaTta2020AY.1060.006698
ORF1ab/nsp13295L295LCtaTta1319AY.30.000129
ORF1ab/nsp13295L295LctActG519AY.30.00005
ORF1ab/nsp13295L295LctActT119AY.30.00001
ORF1ab/nsp13295L295LCtaTta1619B.10.000147
ORF1ab/nsp13295L295LctActT219B.10.000018
ORF1ab/nsp13295L295LctActG119B.10.000009
ORF1ab/nsp13295L295LCtaTta1919B.1.6270.038384
ORF1ab/nsp13295L295LCtaTta1214AY.200.000466
ORF1ab/nsp13295L295LctActT214AY.200.000078
ORF1ab/nsp13295L295LCtaTta814B.1.3510.000238
ORF1ab/nsp13295L295LctActG614B.1.3510.000178
ORF1ab/nsp13295L295LCtaTta1414B.1.438.10.001502
ORF1ab/nsp13295L295LCtaTta814P.10.000126
ORF1ab/nsp13295L295LctActC614P.10.000095
ORF1ab/nsp13295L295LCtaTta1313AY.750.000728
ORF1ab/nsp13295L295LCtaTta1313B.1.360.001897
ORF1ab/nsp13295L295LCtaTta612AY.1020.000159
ORF1ab/nsp13295L295LctActG312AY.1020.00008
ORF1ab/nsp13295L295LctActT312AY.1020.00008
ORF1ab/nsp13295L295LCtaTta912B.1.10.000163
ORF1ab/nsp13295L295LctActG212B.1.10.000036
ORF1ab/nsp13295L295LctActT112B.1.10.000018
ORF1ab/nsp13295L295LCtaTta1212B.1.1.5190.000477
ORF1ab/nsp13295L295LCtaTta1111B.1.1.3720.007576
ORF1ab/nsp13295L295LCtaTta710AY.1190.000247
ORF1ab/nsp13295L295LctActG310AY.1190.000106
ORF1ab/nsp13295L295LctActT99B.1.1.3180.002716
ORF1ab/nsp13295L295LCtaTta99B.1.36.170.004447
ORF1ab/nsp13295L295LCtaTta99Q.80.001484
ORF1ab/nsp13295L295LCtaTta58AY.390.000124
ORF1ab/nsp13295L295LctActG28AY.390.000049
ORF1ab/nsp13295L295LctActT18AY.390.000025
ORF1ab/nsp13295L295LCtaTta88AY.470.000249
ORF1ab/nsp13295L295LctActT88B.1.1.4810.571429
ORF1ab/nsp13295L295LCtaTta57AY.50.000103
ORF1ab/nsp13295L295LctActG27AY.50.000041
ORF1ab/nsp13295L295LCtaTta67B.1.1600.000187
ORF1ab/nsp13295L295LctActT17B.1.1600.000031
ORF1ab/nsp13295L295LctActT66AY.1180.000376
ORF1ab/nsp13295L295LCtaTta66AY.350.001398
ORF1ab/nsp13295L295LCtaTta66B.1.1.2160.005343
ORF1ab/nsp13295L295LCtaTta55B.1.1.100.005574
ORF1ab/nsp13295L295LCtaTta55C.380.040323
ORF1ab/nsp13295L295LCtaTta55P.1.170.000809
ORF1ab/nsp13295L295LCtaTta44AY.160.001519
ORF1ab/nsp13295L295LCtaTta44AY.230.000279
ORF1ab/nsp13295L295LCtaTta44AY.4.2.10.000596
ORF1ab/nsp13295L295LCtaTta44AY.46.60.000289
ORF1ab/nsp13295L295LCtaTta44AY.740.000463
ORF1ab/nsp13295L295LCtaTta44AY.90.00027
ORF1ab/nsp13295L295LCtaTta34B.1.5960.000261
ORF1ab/nsp13295L295LctActG14B.1.5960.000087
ORF1ab/nsp13295L295LCtaTta44P.1.150.000929
ORF1ab/nsp13295L295LctActG44Q.30.00058
ORF1ab/nsp13295L295LCtaTta33AE.80.001467
ORF1ab/nsp13295L295LCtaTta33AY.1110.000549
ORF1ab/nsp13295L295LCtaTta33AY.1200.000112
ORF1ab/nsp13295L295LCtaTta23AY.140.000176
ORF1ab/nsp13295L295LctActG13AY.140.000088
ORF1ab/nsp13295L295LCtaTta23AY.290.000032
ORF1ab/nsp13295L295LctActG13AY.290.000016
ORF1ab/nsp13295L295LctActG33AY.530.000863
ORF1ab/nsp13295L295LctActT33AY.570.001969
ORF1ab/nsp13295L295LCtaTta33B.1.1.2860.008696
ORF1ab/nsp13295L295LctActC33B.1.177.120.000455
ORF1ab/nsp13295L295LCtaTta33B.1.177.430.004431
ORF1ab/nsp13295L295LCtaTta23B.1.5260.000047
ORF1ab/nsp13295L295LctActT13B.1.5260.000024
ORF1ab/nsp13295L295LCtaTta33B.1.6210.000266
ORF1ab/nsp13295L295LCtaTta22A.2.50.000998
ORF1ab/nsp13295L295LctActT22A.220.133333
ORF1ab/nsp13295L295LCtaTta22AY.1000.000092
ORF1ab/nsp13295L295LCtaTta22AY.130.000322
ORF1ab/nsp13295L295LCtaTta22AY.330.000134
ORF1ab/nsp13295L295LCtaTta22AY.360.000296
ORF1ab/nsp13295L295LCtaTta12AY.39.10.00004
ORF1ab/nsp13295L295LctActG12AY.39.10.00004
ORF1ab/nsp13295L295LCtaTta22AY.450.000243
ORF1ab/nsp13295L295LCtaTta12AY.460.000104
ORF1ab/nsp13295L295LctActT12AY.460.000104
ORF1ab/nsp13295L295LCtaTta22AY.540.000191
ORF1ab/nsp13295L295LCtaTta22AY.60.000082
ORF1ab/nsp13295L295LCtaTta22AY.9.10.000167
ORF1ab/nsp13295L295LCtaTta22AY.98.10.000097
ORF1ab/nsp13295L295LCtaTta22AY.99.20.000184
ORF1ab/nsp13295L295LCtaTta22B.1.1.2140.000111
ORF1ab/nsp13295L295LCtaTta22B.1.1.370.000386
ORF1ab/nsp13295L295LctActG12B.1.1.4320.001266
ORF1ab/nsp13295L295LCtaTta12B.1.1.4320.001266
ORF1ab/nsp13295L295LCtaTta22B.1.1260.002551
ORF1ab/nsp13295L295LCtaTta22B.1.177.110.003396
ORF1ab/nsp13295L295LCtaTta22B.1.177.30.015267
ORF1ab/nsp13295L295LCtaTta22B.1.177.40.000422
ORF1ab/nsp13295L295LCtaTta22B.1.177.830.002963
ORF1ab/nsp13295L295LCtaTta22B.1.1790.007519
ORF1ab/nsp13295L295LCtaTta12B.1.2210.000071
ORF1ab/nsp13295L295LctActG12B.1.2210.000071
ORF1ab/nsp13295L295LCtaTta12B.1.2430.00007
ORF1ab/nsp13295L295LctActG12B.1.2430.00007
ORF1ab/nsp13295L295LCtaTta22B.1.3110.000549
ORF1ab/nsp13295L295LCtaTta22B.1.36.290.001035
ORF1ab/nsp13295L295LCtaTta12B.1.4290.000024
ORF1ab/nsp13295L295LctActG12B.1.4290.000024
ORF1ab/nsp13295L295LCtaTta11A0.000387
ORF1ab/nsp13295L295LCtaTta11AD.20.000219
ORF1ab/nsp13295L295LCtaTta11AY.100.00053
ORF1ab/nsp13295L295LCtaTta11AY.1080.001103
ORF1ab/nsp13295L295LCtaTta11AY.110.001339
ORF1ab/nsp13295L295LctActG11AY.1160.000287
ORF1ab/nsp13295L295LCtaTta11AY.1170.000085
ORF1ab/nsp13295L295LctActT11AY.16.10.00047
ORF1ab/nsp13295L295LCtaTta11AY.260.000028
ORF1ab/nsp13295L295LCtaTta11AY.300.000396
ORF1ab/nsp13295L295LCtaTta11AY.39.20.001541
ORF1ab/nsp13295L295LCtaTta11AY.4.40.000409
ORF1ab/nsp13295L295LCtaTta11AY.420.00004
ORF1ab/nsp13295L295LCtaTta11AY.5.20.002463
ORF1ab/nsp13295L295LCtaTta11AY.550.000917
ORF1ab/nsp13295L295LCtaTta11AY.610.000105
ORF1ab/nsp13295L295LCtaTta11AY.620.000436
ORF1ab/nsp13295L295LctActC11AY.690.000187
ORF1ab/nsp13295L295LCtaTta11AY.75.10.00018
ORF1ab/nsp13295L295LCtaTta11AY.890.004902
ORF1ab/nsp13295L295LctActG11AY.9.20.000037
ORF1ab/nsp13295L295LCtaTta11AY.980.000079
ORF1ab/nsp13295L295LctActG11B0.000128
ORF1ab/nsp13295L295LCtaTta11B.1.1.1810.004545
ORF1ab/nsp13295L295LCtaTta11B.1.1.2650.003155
ORF1ab/nsp13295L295LCtaTta11B.1.1.4160.000905
ORF1ab/nsp13295L295LCtaTta11B.1.1.4340.000349
ORF1ab/nsp13295L295LctActT11B.1.1.520.012195
ORF1ab/nsp13295L295LCtaTta11B.1.1.5250.005464
ORF1ab/nsp13295L295LCtaTta11B.1.160.320.004292
ORF1ab/nsp13295L295LCtaTta11B.1.177.500.004695
ORF1ab/nsp13295L295LCtaTta11B.1.177.650.000665
ORF1ab/nsp13295L295LCtaTta11B.1.2340.000132
ORF1ab/nsp13295L295LCtaTta11B.1.2400.000216
ORF1ab/nsp13295L295LCtaTta11B.1.2580.000067
ORF1ab/nsp13295L295LCtaTta11B.1.351.20.000303
ORF1ab/nsp13295L295LCtaTta11B.1.351.30.000876
ORF1ab/nsp13295L295LCtaTta11B.1.4270.00005
ORF1ab/nsp13295L295LCtaTta11B.1.4520.013699
ORF1ab/nsp13295L295LCtaTta11B.1.5650.00081
ORF1ab/nsp13295L295LCtaTta11B.1.6090.000479
ORF1ab/nsp13295L295LctActG11B.1.617.10.000129
ORF1ab/nsp13295L295LCtaTta11B.290.003509
ORF1ab/nsp13295L295LctActG11C.36.3.10.002717
ORF1ab/nsp13295L295LCtaTta11C.370.000116
ORF1ab/nsp13295L295LCtaTta11D.20.000075
ORF1ab/nsp13295L295LCtaTta11P.1.70.000319
ORF1ab/nsp13295L295LCtaTta11Q.10.000126
ORF1ab/nsp13295L295LCtaTta11V.10.022727

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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