CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = I151V
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp13 | 151 | I151V | I5475V | nonsyn | Att | Gtt | 2593 | 2593 | 1 | 16687-16689 |
Details of the mutation I151V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2593 | 2593 | All | 0.000496 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1130 | 1130 | B.1.351.3 | 0.990359 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 318 | 318 | B.1.617.2 | 0.001197 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 104 | 104 | AY.33 | 0.006945 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 104 | 104 | AY.43 | 0.000461 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 101 | 101 | AY.4 | 0.000157 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 70 | 70 | B.1.1.7 | 0.000063 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 63 | 63 | AY.25 | 0.000379 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 58 | 58 | B.1.351.2 | 0.017549 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 56 | 56 | AY.103 | 0.000348 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 37 | 37 | B.1.351 | 0.0011 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 36 | 36 | AY.44 | 0.000219 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 36 | 36 | B.1.637 | 0.002631 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 29 | 29 | AY.4.4 | 0.011866 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 28 | 28 | AY.75 | 0.001569 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 27 | 27 | AY.39.1 | 0.00107 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 24 | 24 | B.1.570 | 0.070588 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 23 | 23 | AY.39 | 0.000568 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 22 | 22 | AY.26 | 0.000623 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 21 | 21 | B.1 | 0.000192 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 16 | 16 | AY.3 | 0.000159 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 16 | 16 | AY.47 | 0.000498 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 15 | 15 | B.1.398 | 0.044643 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 14 | 14 | AY.32 | 0.007455 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 14 | 14 | B.1.1 | 0.000254 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 11 | 11 | AY.102 | 0.000292 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 9 | 9 | B.1.1.28 | 0.002801 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 9 | 9 | B.1.2 | 0.000079 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | AY.119 | 0.000247 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | AY.5 | 0.000145 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | B.1.258 | 0.000466 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | B.1.427 | 0.000353 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | B.1.429 | 0.000165 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 7 | 7 | P.1 | 0.00011 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 6 | 6 | B | 0.000767 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 6 | 6 | B.1.1.269 | 0.008119 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 6 | 6 | B.1.526 | 0.000141 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 6 | 6 | C.38 | 0.048387 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 5 | 5 | AY.23 | 0.000349 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 5 | 5 | B.1.243 | 0.000348 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 5 | 5 | B.1.357 | 0.047619 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | AY.113 | 0.00057 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | AY.84 | 0.00175 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | AY.98 | 0.000316 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | B.1.1.306 | 0.001754 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 4 | 4 | B.1.177.4 | 0.000844 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.120.1 | 0.000963 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.13 | 0.000483 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.20 | 0.000117 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | B.1.1.243 | 0.012245 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | B.1.1.374 | 0.007126 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 3 | 3 | B.1.177.56 | 0.002003 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | 0.111111 | |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | AY.29 | 0.000032 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | AY.30 | 0.000791 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | AY.34 | 0.000194 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | AY.94 | 0.000885 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | B.1.110.3 | 0.001437 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 2 | 2 | B.1.621 | 0.000177 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.1 | 0.000396 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.101 | 0.00049 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.106 | 0.000335 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.108 | 0.001103 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.11 | 0.001339 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.19 | 0.00114 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.23.1 | 0.000417 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.46.1 | 0.001027 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.46.3 | 0.000934 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.5.4 | 0.000277 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.9 | 0.000068 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.1.273 | 0.006757 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.142 | 0.002899 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.177.44 | 0.000519 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.177.60 | 0.000218 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.326 | 0.007576 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.443 | 0.004673 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.554 | 0.004405 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.565 | 0.00081 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.577 | 0.000687 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.3 | 0.000831 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.40 | 0.000364 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | B.45 | 0.003831 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | C.36.3 | 0.000567 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp13 | 151 | I151V | Att | Gtt | 1 | 1 | Q.1 | 0.000126 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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