CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = I151L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp13	151	I151L	I5475L	nonsyn	Att	Ctt	17	13	0.764706	16687-16689
ORF1ab/nsp13	151	I151L	I5475L	nonsyn	AtT	CtC	17	2	0.117647	16687-16689
ORF1ab/nsp13	151	I151L	I5475L	nonsyn	AtT	CtG	17	2	0.117647	16687-16689

Details of the mutation I151L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp13	151	I151L	Att	Ctt	13	17	All	0.000002
ORF1ab/nsp13	151	I151L	AtT	CtG	2	17	All	0
ORF1ab/nsp13	151	I151L	AtT	CtC	2	17	All	0
ORF1ab/nsp13	151	I151L	Att	Ctt	7	7	AY.3	0.00007
ORF1ab/nsp13	151	I151L	Att	Ctt	2	6		0.111111
ORF1ab/nsp13	151	I151L	AtT	CtC	2	6		0.111111
ORF1ab/nsp13	151	I151L	AtT	CtG	2	6		0.111111
ORF1ab/nsp13	151	I151L	Att	Ctt	1	1	AY.44	0.000006
ORF1ab/nsp13	151	I151L	Att	Ctt	1	1	AY.98.1	0.000048
ORF1ab/nsp13	151	I151L	Att	Ctt	1	1	B.1.1.176	0.000439
ORF1ab/nsp13	151	I151L	Att	Ctt	1	1	B.1.1.7	0.000001

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.