CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : Mut = I151I

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp13	151	I151I	I5475I	syn	atT	atA	188	105	0.558511	16687-16689
ORF1ab/nsp13	151	I151I	I5475I	syn	atT	atC	188	83	0.441489	16687-16689

Details of the mutation I151I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp13	151	I151I	atT	atA	105	188	All	0.00002
ORF1ab/nsp13	151	I151I	atT	atC	83	188	All	0.000016
ORF1ab/nsp13	151	I151I	atT	atA	44	53	AY.4	0.000068
ORF1ab/nsp13	151	I151I	atT	atC	9	53	AY.4	0.000014
ORF1ab/nsp13	151	I151I	atT	atC	22	22	B.1.526	0.000517
ORF1ab/nsp13	151	I151I	atT	atA	15	21	AY.43	0.000066
ORF1ab/nsp13	151	I151I	atT	atC	6	21	AY.43	0.000027
ORF1ab/nsp13	151	I151I	atT	atA	13	15	B.1.617.2	0.000049
ORF1ab/nsp13	151	I151I	atT	atC	2	15	B.1.617.2	0.000008
ORF1ab/nsp13	151	I151I	atT	atA	10	10	AY.117	0.000845
ORF1ab/nsp13	151	I151I	atT	atC	7	10	B.1.1.7	0.000006
ORF1ab/nsp13	151	I151I	atT	atA	3	10	B.1.1.7	0.000003
ORF1ab/nsp13	151	I151I	atT	atC	5	8	B.1.2	0.000044
ORF1ab/nsp13	151	I151I	atT	atA	3	8	B.1.2	0.000026
ORF1ab/nsp13	151	I151I	atT	atA	3	4	AY.39	0.000074
ORF1ab/nsp13	151	I151I	atT	atC	1	4	AY.39	0.000025
ORF1ab/nsp13	151	I151I	atT	atC	4	4	AY.44	0.000024
ORF1ab/nsp13	151	I151I	atT	atA	2	3	AY.102	0.000053
ORF1ab/nsp13	151	I151I	atT	atC	1	3	AY.102	0.000027
ORF1ab/nsp13	151	I151I	atT	atC	2	3	AY.3	0.00002
ORF1ab/nsp13	151	I151I	atT	atA	1	3	AY.3	0.00001
ORF1ab/nsp13	151	I151I	atT	atA	3	3	B.1.177	0.00004
ORF1ab/nsp13	151	I151I	atT	atC	3	3	B.1.177.17	0.002463
ORF1ab/nsp13	151	I151I	atT	atC	2	2	B.1.1.220	0.003717
ORF1ab/nsp13	151	I151I	atT	atC	2	2	B.1.1.243	0.008163
ORF1ab/nsp13	151	I151I	atT	atC	2	2	B.1.258	0.000133
ORF1ab/nsp13	151	I151I	atT	atA	2	2	B.1.637	0.000146
ORF1ab/nsp13	151	I151I	atT	atC	2	2	B.40	0.000729
ORF1ab/nsp13	151	I151I	atT	atA	2	2	P.1.14	0.000096
ORF1ab/nsp13	151	I151I	atT	atA	1	1	A	0.000387
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.103	0.000006
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.106	0.000335
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.120	0.000037
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.23	0.00007
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.27	0.000065
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.6	0.000041
ORF1ab/nsp13	151	I151I	atT	atA	1	1	AY.85	0.000427
ORF1ab/nsp13	151	I151I	atT	atA	1	1	AY.92	0.000287
ORF1ab/nsp13	151	I151I	atT	atC	1	1	AY.99.2	0.000092
ORF1ab/nsp13	151	I151I	atT	atC	1	1	B.1	0.000009
ORF1ab/nsp13	151	I151I	atT	atA	1	1	B.1.1	0.000018
ORF1ab/nsp13	151	I151I	atT	atC	1	1	B.1.1.25	0.000569
ORF1ab/nsp13	151	I151I	atT	atC	1	1	B.1.36.36	0.000602
ORF1ab/nsp13	151	I151I	atT	atC	1	1	B.1.580	0.004065
ORF1ab/nsp13	151	I151I	atT	atC	1	1	B.1.619.1	0.000641
ORF1ab/nsp13	151	I151I	atT	atC	1	1	D.2	0.000075

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.