CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : CodonNum = 524 & Codon = aaA
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp13 | 524 | K524K | K5848K | syn | aaG | aaA | 1311 | 1311 | 1 | 17806-17808 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1311 | 1311 | All | 0.000251 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 507 | 507 | B.1.1.7 | 0.000454 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 110 | 110 | AA.4 | 1 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 96 | 96 | B.1.617.2 | 0.000361 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 83 | 83 | B.1.526 | 0.001951 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 59 | 59 | AY.5 | 0.001218 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 54 | 54 | P.1 | 0.000851 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 40 | 40 | AY.35 | 0.009322 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 27 | 27 | B.1.2 | 0.000238 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 24 | 24 | B.1.429 | 0.000565 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 23 | 23 | AY.4 | 0.000036 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 20 | 20 | AY.44 | 0.000122 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 17 | 17 | B.1.637 | 0.001242 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 16 | 16 | B.1.234 | 0.002111 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 11 | 11 | AY.102 | 0.000292 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 10 | 10 | AY.25 | 0.00006 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 10 | 10 | R.1 | 0.0009 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 9 | 9 | B.1.1.519 | 0.000357 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 9 | 9 | B.1.621 | 0.000797 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 9 | 9 | P.1.10 | 0.002425 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 8 | 8 | AY.16.1 | 0.003759 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 8 | 8 | B.1.351 | 0.000238 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 8 | 8 | B.1.427 | 0.000404 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 7 | 7 | AY.103 | 0.000043 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 6 | 6 | AY.26 | 0.00017 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 6 | 6 | AY.43 | 0.000027 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 6 | 6 | B.1.1.318 | 0.001811 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 6 | 6 | B.1.1.434 | 0.002091 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 6 | 6 | P.1.17 | 0.000971 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 5 | 5 | AY.3 | 0.00005 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 5 | 5 | AY.39.1 | 0.000198 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 5 | 5 | B.1.36 | 0.00073 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 5 | 5 | Q.3 | 0.000725 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 4 | 4 | AY.98.1 | 0.000194 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 4 | 4 | B.1.1.28 | 0.001245 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 4 | 4 | B.1.1.523 | 0.00625 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 4 | 4 | P.2 | 0.000747 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | AY.13 | 0.000483 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | B.1 | 0.000027 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | B.1.1 | 0.000054 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | B.1.160.23 | 0.014493 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | B.1.177.77 | 0.002179 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | B.1.609 | 0.001438 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | C.36.3 | 0.001702 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 3 | 3 | C.37 | 0.000348 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | A.2.5 | 0.000998 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | B.1.221 | 0.000142 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | B.1.575 | 0.000607 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 2 | 2 | B.1.631 | 0.006734 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | A.2.3 | 0.004739 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AE.8 | 0.000489 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.1 | 0.000396 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.2 | 0.000356 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.22 | 0.002092 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.48 | 0.000465 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.52 | 0.000814 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.68 | 0.000274 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | AZ.3 | 0.00152 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.1.316 | 0.000925 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.147 | 0.000756 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.221.3 | 0.000833 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.233 | 0.014085 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.349 | 0.000715 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.400 | 0.000429 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.1.636 | 0.006711 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | B.3 | 0.000831 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | P.1.13 | 0.000898 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | Q.4 | 0.000455 |
| ORF1ab/nsp13 | 524 | K524K | aaG | aaA | 1 | 1 | Q.5 | 0.016949 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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