CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : CodonNum = 452

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp13452V452VV5776VsyngtGgtT12186820.55993417590-17592
ORF1ab/nsp13452V452VV5776VsyngtGgtA12185320.43678217590-17592
ORF1ab/nsp13452V452VV5776VsyngtGgtC121840.0032840717590-17592
ORF1ab/nsp13452V452LV5776LnonsynGtgTtg4894830.9877317590-17592
ORF1ab/nsp13452V452LV5776LnonsynGtgCtg48950.010224917590-17592
ORF1ab/nsp13452V452LV5776LnonsynGtGTtA48910.0020449917590-17592
ORF1ab/nsp13452V452delV5776deldelGTG---1717117590-17592
ORF1ab/nsp13452V452AV5776AnonsyngTggCg17130.76470617590-17592
ORF1ab/nsp13452V452AV5776AnonsyngTGgCC1720.11764717590-17592
ORF1ab/nsp13452V452AV5776AnonsyngTGgCA1720.11764717590-17592
ORF1ab/nsp13452V452MV5776MnonsynGtgAtg1212117590-17592
ORF1ab/nsp13452V452GV5776GnonsyngTGgGC620.33333317590-17592
ORF1ab/nsp13452V452GV5776GnonsyngTGgGA620.33333317590-17592
ORF1ab/nsp13452V452GV5776GnonsyngTGgGT610.16666717590-17592
ORF1ab/nsp13452V452GV5776GnonsyngTggGg610.16666717590-17592
ORF1ab/nsp13452V452del1V5776del1delGtg-tg540.817590-17592
ORF1ab/nsp13452V452del1V5776del1delGtGAt-510.217590-17592
ORF1ab/nsp13452V452RV5776RnonsynGTGCGT420.517590-17592
ORF1ab/nsp13452V452TV5776TnonsynGTGACA420.517590-17592
ORF1ab/nsp13452V452TV5776TnonsynGTGACC420.517590-17592
ORF1ab/nsp13452V452RV5776RnonsynGTGAGA420.517590-17592
ORF1ab/nsp13452V452KV5776KnonsynGTGAAA420.517590-17592
ORF1ab/nsp13452V452KV5776KnonsynGTgAAg420.517590-17592
ORF1ab/nsp13452V452EV5776EnonsyngTggAg33117590-17592
ORF1ab/nsp13452V452IV5776InonsynGtGAtA22117590-17592
ORF1ab/nsp13452V452SV5776SnonsynGTGAGC22117590-17592
ORF1ab/nsp13452V452del2V5776del2delgTGg--11117590-17592

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp13452V452VgtGgtT6821218All0.00013
ORF1ab/nsp13452V452VgtGgtA5321218All0.000102
ORF1ab/nsp13452V452VgtGgtC41218All0.000001
ORF1ab/nsp13452V452LGtgTtg483489All0.000092
ORF1ab/nsp13452V452LGtgCtg5489All0.000001
ORF1ab/nsp13452V452LGtGTtA1489All0
ORF1ab/nsp13452V452VgtGgtA392463AY.40.00061
ORF1ab/nsp13452V452VgtGgtT71463AY.40.000111
ORF1ab/nsp13452V452LGtgTtg260260B.10.002381
ORF1ab/nsp13452V452VgtGgtT105124B.1.1.70.000094
ORF1ab/nsp13452V452VgtGgtA19124B.1.1.70.000017
ORF1ab/nsp13452V452VgtGgtA7286AY.1030.000447
ORF1ab/nsp13452V452VgtGgtT1486AY.1030.000087
ORF1ab/nsp13452V452VgtGgtT5353AY.430.000235
ORF1ab/nsp13452V452VgtGgtT5050B.1.438.10.005363
ORF1ab/nsp13452V452VgtGgtT5050P.10.000788
ORF1ab/nsp13452V452VgtGgtT3537B.1.617.20.000132
ORF1ab/nsp13452V452VgtGgtA237B.1.617.20.000008
ORF1ab/nsp13452V452LGtgTtg3132B.1.1.70.000028
ORF1ab/nsp13452V452LGtGTtA132B.1.1.70.000001
ORF1ab/nsp13452V452VgtGgtT3131C.90.939394
ORF1ab/nsp13452V452LGtgTtg2323B.1.1.3780.167883
ORF1ab/nsp13452V452VgtGgtT1818B.1.619.10.011546
ORF1ab/nsp13452V452delGTG---1717All0.000003
ORF1ab/nsp13452V452AgTggCg1317All0.000002
ORF1ab/nsp13452V452AgTGgCA217All0
ORF1ab/nsp13452V452AgTGgCC217All0
ORF1ab/nsp13452V452LGtgTtg1717AY.430.000075
ORF1ab/nsp13452V452VgtGgtT1617B.10.000147
ORF1ab/nsp13452V452VgtGgtA117B.10.000009
ORF1ab/nsp13452V452VgtGgtA1417B.1.4270.000707
ORF1ab/nsp13452V452VgtGgtT317B.1.4270.000151
ORF1ab/nsp13452V452VgtGgtT1516B.1.10.000272
ORF1ab/nsp13452V452VgtGgtA116B.1.10.000018
ORF1ab/nsp13452V452LGtgTtg1313B.1.617.20.000049
ORF1ab/nsp13452V452MGtgAtg1212All0.000002
ORF1ab/nsp13452V452LGtgTtg1212AY.40.000019
ORF1ab/nsp13452V452VgtGgtT1212B.1.1.5190.000477
ORF1ab/nsp13452V452LGtgTtg1111AY.250.000066
ORF1ab/nsp13452V452VgtGgtT610AY.440.000037
ORF1ab/nsp13452V452VgtGgtA410AY.440.000024
ORF1ab/nsp13452V452VgtGgtT1010AY.480.004651
ORF1ab/nsp13452V452VgtGgtT99AY.1140.00208
ORF1ab/nsp13452V452VgtGgtT99B.1.1.3120.017208
ORF1ab/nsp13452V452VgtGgtT99B.1.20.000079
ORF1ab/nsp13452V452LGtgTtg78B.1.20.000062
ORF1ab/nsp13452V452LGtgCtg18B.1.20.000009
ORF1ab/nsp13452V452LGtgTtg88B.1.2210.000568
ORF1ab/nsp13452V452LGtgTtg88B.1.360.001167
ORF1ab/nsp13452V452GgTGgGC26All0
ORF1ab/nsp13452V452GgTGgGA26All0
ORF1ab/nsp13452V452GgTggGg16All0
ORF1ab/nsp13452V452GgTGgGT16All0
ORF1ab/nsp13452V452VgtGgtT66AY.260.00017
ORF1ab/nsp13452V452delGTG---66B.1.1.70.000005
ORF1ab/nsp13452V452VgtGgtT66B.1.3110.001647
ORF1ab/nsp13452V452VgtGgtT66B.6.60.005333
ORF1ab/nsp13452V452del1Gtg-tg45All0.000001
ORF1ab/nsp13452V452del1GtGAt-15All0
ORF1ab/nsp13452V452VgtGgtT45AY.1130.00057
ORF1ab/nsp13452V452VgtGgtA15AY.1130.000142
ORF1ab/nsp13452V452VgtGgtT45AY.1200.000149
ORF1ab/nsp13452V452VgtGgtA15AY.1200.000037
ORF1ab/nsp13452V452VgtGgtT55AY.230.000349
ORF1ab/nsp13452V452VgtGgtT55AY.30.00005
ORF1ab/nsp13452V452VgtGgtA55AY.300.001979
ORF1ab/nsp13452V452VgtGgtT45AY.390.000099
ORF1ab/nsp13452V452VgtGgtA15AY.390.000025
ORF1ab/nsp13452V452LGtgTtg55AY.440.00003
ORF1ab/nsp13452V452VgtGgtT55AY.470.000156
ORF1ab/nsp13452V452LGtgTtg55AY.740.000578
ORF1ab/nsp13452V452VgtGgtA55B.1.1600.000156
ORF1ab/nsp13452V452VgtGgtT55B.1.177.70.000824
ORF1ab/nsp13452V452VgtGgtA35B.1.2210.000213
ORF1ab/nsp13452V452VgtGgtT25B.1.2210.000142
ORF1ab/nsp13452V452VgtGgtT45B.1.6210.000354
ORF1ab/nsp13452V452VgtGgtA15B.1.6210.000089
ORF1ab/nsp13452V452RGTGAGA240.111111
ORF1ab/nsp13452V452RGTGCGT240.111111
ORF1ab/nsp13452V452KGTGAAA240.111111
ORF1ab/nsp13452V452GgTGgGC240.111111
ORF1ab/nsp13452V452GgTGgGA240.111111
ORF1ab/nsp13452V452KGTgAAg240.111111
ORF1ab/nsp13452V452AgTGgCC240.111111
ORF1ab/nsp13452V452AgTGgCA240.111111
ORF1ab/nsp13452V452TGTGACC240.111111
ORF1ab/nsp13452V452TGTGACA240.111111
ORF1ab/nsp13452V452KGTGAAA24All0
ORF1ab/nsp13452V452RGTGCGT24All0
ORF1ab/nsp13452V452TGTGACC24All0
ORF1ab/nsp13452V452KGTgAAg24All0
ORF1ab/nsp13452V452TGTGACA24All0
ORF1ab/nsp13452V452RGTGAGA24All0
ORF1ab/nsp13452V452VgtGgtT44AY.1000.000184
ORF1ab/nsp13452V452LGtgTtg44AY.1030.000025
ORF1ab/nsp13452V452VgtGgtT34AY.250.000018
ORF1ab/nsp13452V452VgtGgtC14AY.250.000006
ORF1ab/nsp13452V452VgtGgtT44AY.940.001771
ORF1ab/nsp13452V452VgtGgtT44B.1.1.250.002274
ORF1ab/nsp13452V452VgtGgtT44B.1.1770.000053
ORF1ab/nsp13452V452LGtgTtg44B.1.177.40.000844
ORF1ab/nsp13452V452AgTggCg44B.1.3510.000119
ORF1ab/nsp13452V452VgtGgtT44B.1.4290.000094
ORF1ab/nsp13452V452LGtgTtg44B.1.5260.000094
ORF1ab/nsp13452V452VgtGgtT44B.1.6020.026144
ORF1ab/nsp13452V452VgtGgtT44B.450.015326
ORF1ab/nsp13452V452LGtgTtg44P.10.000063
ORF1ab/nsp13452V452VgtGgtT44P.1.140.000191
ORF1ab/nsp13452V452EgTggAg33All0.000001
ORF1ab/nsp13452V452LGtgTtg33AY.30.00003
ORF1ab/nsp13452V452VgtGgtT33AY.46.60.000217
ORF1ab/nsp13452V452VgtGgtT33B.1.1.2770.002276
ORF1ab/nsp13452V452VgtGgtT33B.1.1.4340.001046
ORF1ab/nsp13452V452AgTggCg33B.1.1.70.000003
ORF1ab/nsp13452V452LGtgTtg33B.1.1470.002268
ORF1ab/nsp13452V452LGtgTtg33B.1.1770.00004
ORF1ab/nsp13452V452VgtGgtT33B.1.351.20.000908
ORF1ab/nsp13452V452LGtgTtg23B.1.4270.000101
ORF1ab/nsp13452V452LGtgCtg13B.1.4270.00005
ORF1ab/nsp13452V452LGtgTtg33B.360.230769
ORF1ab/nsp13452V452VgtGgtA23P.1.70.000639
ORF1ab/nsp13452V452VgtGgtT13P.1.70.000319
ORF1ab/nsp13452V452SGTGAGC220.111111
ORF1ab/nsp13452V452IGtGAtA220.111111
ORF1ab/nsp13452V452MGtgAtg220.111111
ORF1ab/nsp13452V452LGtgTtg22A.2.20.003378
ORF1ab/nsp13452V452LGtgCtg22AD.20.000438
ORF1ab/nsp13452V452SGTGAGC22All0
ORF1ab/nsp13452V452IGtGAtA22All0
ORF1ab/nsp13452V452VgtGgtT22AY.1010.000981
ORF1ab/nsp13452V452VgtGgtT22AY.1110.000366
ORF1ab/nsp13452V452VgtGgtT22AY.1180.000125
ORF1ab/nsp13452V452LGtgTtg22AY.290.000032
ORF1ab/nsp13452V452VgtGgtT22AY.290.000032
ORF1ab/nsp13452V452VgtGgtT22AY.330.000134
ORF1ab/nsp13452V452VgtGgtA22AY.4.20.000043
ORF1ab/nsp13452V452VgtGgtT22AY.4.30.001684
ORF1ab/nsp13452V452VgtGgtT22AY.4.40.000818
ORF1ab/nsp13452V452LGtgTtg22AY.46.50.000397
ORF1ab/nsp13452V452LGtgTtg22AY.50.000041
ORF1ab/nsp13452V452AgTggCg22B.10.000018
ORF1ab/nsp13452V452LGtgTtg22B.1.10.000036
ORF1ab/nsp13452V452VgtGgtT22B.1.1.10.000653
ORF1ab/nsp13452V452LGtgTtg22B.1.110.30.001437
ORF1ab/nsp13452V452VgtGgtT22B.1.1310.017544
ORF1ab/nsp13452V452VgtGgtA22B.1.177.150.001262
ORF1ab/nsp13452V452VgtGgtT22B.1.3560.003454
ORF1ab/nsp13452V452VgtGgtA12B.1.360.000146
ORF1ab/nsp13452V452VgtGgtT12B.1.360.000146
ORF1ab/nsp13452V452LGtgTtg22B.1.5250.000226
ORF1ab/nsp13452V452LGtgTtg22B.1.5270.007407
ORF1ab/nsp13452V452VgtGgtT22B.1.617.10.000258
ORF1ab/nsp13452V452delGTG---22B.1.617.20.000008
ORF1ab/nsp13452V452MGtgAtg22C.350.001548
ORF1ab/nsp13452V452LGtgCtg12D.20.000075
ORF1ab/nsp13452V452LGtgTtg12D.20.000075
ORF1ab/nsp13452V452VgtGgtT22Q.10.000253
ORF1ab/nsp13452V452VgtGgtT22Q.40.00091
ORF1ab/nsp13452V452del1GtGAt-11A0.000387
ORF1ab/nsp13452V452EgTggAg11A.2.40.003367
ORF1ab/nsp13452V452LGtgTtg11A.2.5.20.001572
ORF1ab/nsp13452V452del2gTGg--11All0
ORF1ab/nsp13452V452VgtGgtT11AY.1020.000027
ORF1ab/nsp13452V452LGtgTtg11AY.1020.000027
ORF1ab/nsp13452V452VgtGgtT11AY.1060.000335
ORF1ab/nsp13452V452LGtgTtg11AY.110.001339
ORF1ab/nsp13452V452LGtgTtg11AY.1170.000085
ORF1ab/nsp13452V452LGtgTtg11AY.1180.000063
ORF1ab/nsp13452V452MGtgAtg11AY.1180.000063
ORF1ab/nsp13452V452VgtGgtT11AY.1190.000035
ORF1ab/nsp13452V452VgtGgtT11AY.23.10.000417
ORF1ab/nsp13452V452VgtGgtC11AY.340.000097
ORF1ab/nsp13452V452VgtGgtT11AY.34.10.00051
ORF1ab/nsp13452V452delGTG---11AY.370.000316
ORF1ab/nsp13452V452LGtgTtg11AY.39.10.00004
ORF1ab/nsp13452V452VgtGgtT11AY.39.10.00004
ORF1ab/nsp13452V452del1Gtg-tg11AY.4.50.000107
ORF1ab/nsp13452V452delGTG---11AY.4.50.000107
ORF1ab/nsp13452V452VgtGgtT11AY.420.00004
ORF1ab/nsp13452V452LGtgTtg11AY.420.00004
ORF1ab/nsp13452V452GgTGgGT11AY.440.000006
ORF1ab/nsp13452V452MGtgAtg11AY.440.000006
ORF1ab/nsp13452V452LGtgTtg11AY.460.000104
ORF1ab/nsp13452V452VgtGgtT11AY.46.40.000165
ORF1ab/nsp13452V452LGtgTtg11AY.46.60.000072
ORF1ab/nsp13452V452LGtgTtg11AY.470.000031
ORF1ab/nsp13452V452VgtGgtA11AY.490.003195
ORF1ab/nsp13452V452VgtGgtT11AY.50.000021
ORF1ab/nsp13452V452MGtgAtg11AY.60.000041
ORF1ab/nsp13452V452LGtgTtg11AY.60.000041
ORF1ab/nsp13452V452VgtGgtT11AY.650.000533
ORF1ab/nsp13452V452delGTG---11AY.670.000464
ORF1ab/nsp13452V452LGtgTtg11AY.7.10.000113
ORF1ab/nsp13452V452VgtGgtT11AY.75.10.00018
ORF1ab/nsp13452V452VgtGgtT11AY.850.000427
ORF1ab/nsp13452V452VgtGgtC11AY.950.000761
ORF1ab/nsp13452V452VgtGgtT11AY.970.001701
ORF1ab/nsp13452V452LGtgTtg11AY.980.000079
ORF1ab/nsp13452V452LGtgTtg11B0.000128
ORF1ab/nsp13452V452VgtGgtA11B0.000128
ORF1ab/nsp13452V452del1Gtg-tg11B.1.10.000018
ORF1ab/nsp13452V452MGtgAtg11B.1.10.000018
ORF1ab/nsp13452V452VgtGgtT11B.1.1.2160.00089
ORF1ab/nsp13452V452AgTggCg11B.1.1.2410.00207
ORF1ab/nsp13452V452VgtGgtT11B.1.1.2690.001353
ORF1ab/nsp13452V452LGtgTtg11B.1.1.2840.000107
ORF1ab/nsp13452V452VgtGgtT11B.1.1.2890.002083
ORF1ab/nsp13452V452LGtgTtg11B.1.1.3070.002532
ORF1ab/nsp13452V452LGtgTtg11B.1.1.3110.000358
ORF1ab/nsp13452V452VgtGgtT11B.1.1.330.000421
ORF1ab/nsp13452V452EgTggAg11B.1.1.390.00051
ORF1ab/nsp13452V452AgTggCg11B.1.1.4020.011111
ORF1ab/nsp13452V452VgtGgtT11B.1.1.500.000679
ORF1ab/nsp13452V452VgtGgtT11B.1.1.5230.001563
ORF1ab/nsp13452V452GgTggGg11B.1.1.70.000001
ORF1ab/nsp13452V452del1Gtg-tg11B.1.1.70.000001
ORF1ab/nsp13452V452del2gTGg--11B.1.1.70.000001
ORF1ab/nsp13452V452LGtgTtg11B.1.1.700.000341
ORF1ab/nsp13452V452LGtgTtg11B.1.1.740.00431
ORF1ab/nsp13452V452LGtgTtg11B.1.1340.005464
ORF1ab/nsp13452V452VgtGgtT11B.1.1400.018868
ORF1ab/nsp13452V452MGtgAtg11B.1.1770.000013
ORF1ab/nsp13452V452VgtGgtT11B.1.177.200.001517
ORF1ab/nsp13452V452VgtGgtT11B.1.177.330.001645
ORF1ab/nsp13452V452LGtgTtg11B.1.177.720.00339
ORF1ab/nsp13452V452delGTG---11B.1.1790.003759
ORF1ab/nsp13452V452AgTggCg11B.1.20.000009
ORF1ab/nsp13452V452AgTggCg11B.1.2060.000816
ORF1ab/nsp13452V452LGtgTtg11B.1.2430.00007
ORF1ab/nsp13452V452VgtGgtT11B.1.2430.00007
ORF1ab/nsp13452V452VgtGgtT11B.1.2580.000067
ORF1ab/nsp13452V452delGTG---11B.1.2580.000067
ORF1ab/nsp13452V452LGtgTtg11B.1.2580.000067
ORF1ab/nsp13452V452LGtgTtg11B.1.258.170.000104
ORF1ab/nsp13452V452MGtgAtg11B.1.3110.000275
ORF1ab/nsp13452V452LGtgTtg11B.1.3360.002439
ORF1ab/nsp13452V452VgtGgtT11B.1.3510.00003
ORF1ab/nsp13452V452del1Gtg-tg11B.1.360.000146
ORF1ab/nsp13452V452VgtGgtA11B.1.36.10.00114
ORF1ab/nsp13452V452VgtGgtT11B.1.36.80.001
ORF1ab/nsp13452V452LGtgTtg11B.1.3660.004878
ORF1ab/nsp13452V452LGtgTtg11B.1.3690.000285
ORF1ab/nsp13452V452VgtGgtT11B.1.400.10.015152
ORF1ab/nsp13452V452MGtgAtg11B.1.4130.004255
ORF1ab/nsp13452V452delGTG---11B.1.4150.014286
ORF1ab/nsp13452V452LGtgTtg11B.1.4530.003236
ORF1ab/nsp13452V452LGtgTtg11B.1.4560.003268
ORF1ab/nsp13452V452VgtGgtT11B.1.5250.000113
ORF1ab/nsp13452V452VgtGgtT11B.1.5400.009709
ORF1ab/nsp13452V452LGtgTtg11B.1.5640.000426
ORF1ab/nsp13452V452VgtGgtC11B.1.5760.000907
ORF1ab/nsp13452V452MGtgAtg11B.1.5820.000491
ORF1ab/nsp13452V452LGtgTtg11B.1.5880.00091
ORF1ab/nsp13452V452LGtgTtg11B.1.6000.005848
ORF1ab/nsp13452V452EgTggAg11B.1.6280.000352
ORF1ab/nsp13452V452delGTG---11B.1.6300.005236
ORF1ab/nsp13452V452LGtgTtg11B.400.000364
ORF1ab/nsp13452V452LGtgTtg11B.550.00295
ORF1ab/nsp13452V452VgtGgtT11B.60.00091
ORF1ab/nsp13452V452delGTG---11C.170.055556
ORF1ab/nsp13452V452VgtGgtT11C.36.30.000567
ORF1ab/nsp13452V452VgtGgtT11C.370.000116
ORF1ab/nsp13452V452VgtGgtT11D.20.000075
ORF1ab/nsp13452V452LGtgTtg11P.1.140.000048
ORF1ab/nsp13452V452VgtGgtT11P.1.150.000232
ORF1ab/nsp13452V452LGtgTtg11P.1.160.000374
ORF1ab/nsp13452V452VgtGgtT11Q.80.000165
ORF1ab/nsp13452V452delGTG---11U.30.003861

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.