CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp13 : CodonNum = 164 & Codon = cCt

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp13	164	H164P	H5488P	nonsyn	cAt	cCt	71	71	1	16726-16728

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp13	164	H164P	cAt	cCt	71	71	All	0.000014
ORF1ab/nsp13	164	H164P	cAt	cCt	31	31	AY.4	0.000048
ORF1ab/nsp13	164	H164P	cAt	cCt	22	22	AY.4.5	0.002365
ORF1ab/nsp13	164	H164P	cAt	cCt	5	5	AY.9	0.000338
ORF1ab/nsp13	164	H164P	cAt	cCt	4	4	AY.8	0.002424
ORF1ab/nsp13	164	H164P	cAt	cCt	2	2	AY.120	0.000074
ORF1ab/nsp13	164	H164P	cAt	cCt	2	2	AY.58	0.001815
ORF1ab/nsp13	164	H164P	cAt	cCt	2	2	B.1.1.7	0.000002
ORF1ab/nsp13	164	H164P	cAt	cCt	1	1	AY.87	0.000833
ORF1ab/nsp13	164	H164P	cAt	cCt	1	1	B.1.599	0.00365
ORF1ab/nsp13	164	H164P	cAt	cCt	1	1	B.1.617.2	0.000004

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.