CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp12 : Mut = V424M

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp12424V424MV4816MnonsynGtgAtg334334114710-14712

Details of the mutation V424M within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp12424V424MGtgAtg334334All0.000064
ORF1ab/nsp12424V424MGtgAtg272272AY.40.000423
ORF1ab/nsp12424V424MGtgAtg1515B.1.1.70.000013
ORF1ab/nsp12424V424MGtgAtg55AY.1200.000186
ORF1ab/nsp12424V424MGtgAtg55AY.9.20.000184
ORF1ab/nsp12424V424MGtgAtg55B.1.1.3580.172414
ORF1ab/nsp12424V424MGtgAtg33AY.250.000018
ORF1ab/nsp12424V424MGtgAtg33B.10.000027
ORF1ab/nsp12424V424MGtgAtg33B.1.1.4860.004732
ORF1ab/nsp12424V424MGtgAtg22A0.000774
ORF1ab/nsp12424V424MGtgAtg22AY.440.000012
ORF1ab/nsp12424V424MGtgAtg22B.1.1600.000062
ORF1ab/nsp12424V424MGtgAtg22B.1.617.20.000008
ORF1ab/nsp12424V424MGtgAtg11AY.290.000016
ORF1ab/nsp12424V424MGtgAtg11AY.300.000396
ORF1ab/nsp12424V424MGtgAtg11AY.430.000004
ORF1ab/nsp12424V424MGtgAtg11AY.560.001605
ORF1ab/nsp12424V424MGtgAtg11AY.9.10.000084
ORF1ab/nsp12424V424MGtgAtg11B.1.10.000018
ORF1ab/nsp12424V424MGtgAtg11B.1.1.5190.00004
ORF1ab/nsp12424V424MGtgAtg11B.1.20.000009
ORF1ab/nsp12424V424MGtgAtg11B.1.2580.000067
ORF1ab/nsp12424V424MGtgAtg11B.1.4700.001404
ORF1ab/nsp12424V424MGtgAtg11B.1.5170.000427
ORF1ab/nsp12424V424MGtgAtg11B.1.617.10.000129
ORF1ab/nsp12424V424MGtgAtg11B.40.002208
ORF1ab/nsp12424V424MGtgAtg11P.10.000016
ORF1ab/nsp12424V424MGtgAtg11Q.30.000145

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.